See What HealthDay Can Do For You
Contact Us

Vit C for Pregnant Smokers May Improve Newborn Lung Function

Newborn lung function improved as measured by forced expiratory flow at three months of age

pregnancy

MONDAY, Dec. 24, 2018 (HealthDay News) -- For pregnant smokers, vitamin C supplementation may improve newborn lung function, according to a study published online Dec. 7 in the American Journal of Respiratory and Critical Care Medicine.

Cindy T. McEvoy, M.D., from the Oregon Health & Science University in Portland, and colleagues conducted a randomized trial at three centers involving 251 pregnant smokers. Participants were randomly assigned at 13 to 23 weeks of gestation to vitamin C (125 women) or placebo (126 women). The primary outcome was the measurement of forced expiratory flow (FEF) at 75 percent of the expired volume (FEF75) at 3 months of age.

The researchers found that the FEF75 of infants of pregnant smokers randomly assigned to vitamin C did not differ compared with that of infants of pregnant smokers randomly assigned to placebo (200.7 versus 188.7 mL/sec; adjusted 95 percent confidence interval for difference, −3.33 to 35.64; P = 0.10); significant differences were seen for FEF50 (436.7 versus 408.5 mL/sec; adjusted 95 percent confidence interval, 6.10 to 61.30; P = 0.02) and FEF25 to 75 (387.4 versus 365.8 mL/sec; adjusted 95 percent confidence interval, 0.92 to 55.34; P = 0.04). There was a negative correlation for infant FEFs with the maternal risk alleles for the α5 nicotinic acetylcholine receptor.

"Vitamin C supplementation in pregnant women who cannot quit smoking may be a safe, inexpensive, and simple intervention to improve their offspring's pulmonary function by blocking some of the effects of in-utero smoke on lung development," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.