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Early Bleeding in Pregnancy Tied to Premature Birth

Risk of preterm prelabor rupture of membranes also higher in those with first-trimester bleeding

FRIDAY, April 7 (HealthDay News) -- Pregnant women diagnosed with bleeding during their first trimester have more premature deliveries and more early membrane rupture than other women, according to research published in the April issue of Obstetrics & Gynecology.

Jemma Johns, M.D., and Eric Jauniaux, M.D., of University College London, studied 214 pregnant women diagnosed with threatened miscarriage in their first trimester and 214 controls without early bleeding.

The researchers found that 11.9 percent of the women with threatened miscarriage symptoms delivered prematurely, while controls had a 5.6 percent premature delivery risk. Women with threatened miscarriage were also more susceptible than controls to preterm prelabor membrane rupture (7 percent versus 1.9 percent). Researchers found no overall difference in mean birth weight or other obstetric complications, but found that the women with threatened miscarriage were more likely to have newborns weighing from 1,501 grams to 2,000 g.

"Women with threatened miscarriage in the first trimester are at increased risk of premature delivery, and this risk factor should be taken into consideration when deciding upon antenatal surveillance and management of their pregnancies," the authors write.

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