Pregnancy Loss Declining After Chorionic Villus Sampling

Researchers' most recent data shows no difference in loss rates after CVS or amniocentesis

THURSDAY, Sept. 7 (HealthDay News) -- During the past 20 years, the pregnancy loss rate in women who undergo chorionic villus sampling (CVS) has dramatically declined and now is no different than the rate in women who undergo amniocentesis, according to a study in the September issue of Obstetrics & Gynecology.

Aaron B. Caughey, M.D., of the University of California San Francisco, and colleagues studied 1983-2003 data on 9,886 CVS and 30,893 amniocentesis procedures performed at a single prenatal diagnostic center.

The researchers found that overall loss rates were 3.12 percent for CVS and 0.83 percent for amniocentesis (adjusted odds ratio 4.23). But when they studied data from 1998-2003, they found that the loss rates were 1.93 percent for CVS and 0.64 percent for amniocentesis. After controlling for gestational age, maternal age and indication for the procedure, they found no significant difference between the two procedures (adjusted odds ratio 1.03).

"Clinicians can use this information, particularly with replication of these findings, to counsel their patients," the authors conclude. "Policy makers, particularly those at the level of training institutions, should consider this information in light of first trimester screening to consider how to expand the number of providers trained in this procedure, so that women who wish to receive earlier diagnostic information will be able to do so."

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