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Delayed Cord Clamping Linked to Reduced Hospital Mortality

Compared with early clamping, delay associated with lower mortality in preterm, very preterm infants

newborn in incubator

THURSDAY, Nov. 9, 2017 (HealthDay News) -- Delayed cord clamping is associated with reduced hospital mortality in preterm infants, according to a review published online Oct. 30 in the American Journal of Obstetrics & Gynecology.

Michael Fogarty, from the University of Sydney, and colleagues conducted a systematic review to compare the effects of delayed versus early cord clamping on hospital mortality and morbidity in preterm infants born at <37 weeks' gestation. Data were included from 18 randomized controlled trials including 2,834 infants.

The researchers found that most infants allocated to delayed clamping were assigned a delay of ≥60 seconds. Delayed clamping was associated with a reduction in hospital mortality (risk ratio [RR], 0.69; risk difference [RD], 0.02). Delayed clamping was also correlated with reduced hospital mortality in three trials with 996 infants aged ≤28 weeks' gestation (RR, 0.7; RD, −0.05). Delayed clamping was correlated with a 2.73 percent increase in peak hematocrit and a 10 percent reduction in the proportion of infants having blood transfusion.

"This systematic review provides high-quality evidence that delayed clamping reduced hospital mortality, which supports current guidelines recommending delayed clamping in preterm infants," the authors write.

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