Radiation Therapy Improves Endometrial Cancer Survival

Largest population study to date analyzed data on more than 21,000 patients with early-stage disease

TUESDAY, Jan. 24 (HealthDay News) -- The largest population analysis to date shows that adjuvant radiation therapy significantly improves survival in women with early-stage endometrial cancer, according to an article in the Jan. 25 issue of the Journal of the American Medical Association.

Christopher M. Lee, M.D., of the University of Utah Medical Center in Salt Lake City, and colleagues analyzed data collected by the U.S. National Cancer Institute on women with stage I node-negative endometrial adenocarcinoma from 1988 through 2001.

Of the 21,249 patients, 4,080 (19.2%) received adjuvant radiation therapy, and 17,169 did not. The mean age at diagnosis was 63.2 years.

The researchers found that adjuvant radiation therapy significantly improved overall and relative survival in patients with stage I endometrial cancer (stage 1C/ grades 1, 3 and 4).

"As the largest reported population analysis to date of adjuvant radiation therapy in early-stage endometrial adenocarcinoma, our study reveals a statistically significant association between improved overall and relative survival and adjuvant radiation therapy in stage 1C disease (grades 1 and 3-4)," the authors write. "Future work is needed to... guide treatment decisions and account for disparities in outcome between varied subsets of patients."

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