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Retinal Vein Occlusion Tied to Cerebrovascular Event Risk

Almost two-fold increase in incidence of cerebrovascular event rate; MI rates not affected

WEDNESDAY, March 16 (HealthDay News) -- Patients with retinal vein occlusion (RVO) have an almost two-fold higher event risk rate for cerebrovascular accident (CVA) compared to controls, but similar rates of myocardial infarction (MI) events, according to a study published in the March issue of the Archives of Ophthalmology.

Winifred Werther, Ph.D., from Genentech Inc. in South San Francisco, and colleagues retrospectively compared the incidence rates of MI and CVA prompting hospitalization in 4,500 patients with branch or central RVO and 13,500 age- and sex-matched controls, from a U.S. population-based health care claims database. Adjusted rate ratios were calculated for the two groups and were adjusted for risk factors affecting outcomes.

The investigators found that the event rates for MI were 0.87 per 100 person-years in patients with RVO and 0.67 per 100 person-years in the controls, and the adjusted rate ratio for MI was 1.03. Event rates for CVA were 1.16 per 100 person-years for patients with RVO and 0.52 per 100 person-years for controls, and the adjusted rate ratio for CVA was 1.72.

"In this retrospective cohort study, patients with RVO had an almost two-fold higher incidence of CVA than that of age- and sex-matched controls. This significantly higher incidence of CVA in patients with RVO held true when adjusting for cardiovascular comorbidities," the authors write.

Several of the study authors disclosed financial ties to Genentech Inc., which funded the study.

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