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Effect of AMD on Vision-Specific Functioning Differs by Ethnicity

Early and late age-related macular degeneration tied to worse VSF for Chinese, not Indian, Malay adults


THURSDAY, March 30, 2017 (HealthDay News) -- For Chinese, but not Indian or Malay adults, early and late age-related macular degeneration (AMD) is associated with worse vision-specific functioning (VSF), according to a study published online March 30 in JAMA Ophthalmology.

Eva K. Fenwick, Ph.D., from the Singapore Eye Research Institute, and colleagues conducted a cross-sectional study involving 10,033 Chinese, Malay, and Indian adults with AMD. Gradable fundus images and Visual Function Index (VF-11) data were available for 99.3 percent of participants.

The researchers found that early AMD was associated with a small reduction in VSF compared with no AMD in adjusted models (2.9 percent; β = −0.12; 95 percent confidence interval [CI], −0.23 to −0.00; P = 0.046) in the Chinese group but not the Indian and Malay groups. Chinese participants with late AMD had a clinically significant loss of VSF (19.1 percent; β = −0.78; 95 percent CI, −1.13 to −0.43; P < 0.001). In the Malay group, compared to those without AMD, those with late AMD had a decrease in VSF (13.5 percent; β = −0.49; 95 percent CI, −1.01 to 0.04; P = 0.07). No correlation was seen for late AMD with VSF in the Indian group.

"Early and late AMD negatively affected VSF in Chinese but not in Indian and Malay participants," the authors write.

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