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Corneal Transplant Methods Have Similar Graft Success

Endothelial keratoplasty associated with more endothelial cell loss than penetrating keratoplasty

THURSDAY, March 4 (HealthDay News) -- Endothelial keratoplasty and penetrating keratoplasty lead to similar success rates for corneal transplants, although endothelial keratoplasty is associated with greater endothelial cell loss, according to a study in the March issue of Ophthalmology.

Marianne O. Price, Ph.D., from the Cornea Research Foundation of America in Indianapolis, and colleagues compared outcomes in patients who underwent corneal transplantation, where 173 patients underwent Descemet's stripping automated endothelial keratoplasty (DSAEK) for a condition at moderate risk for graft failure due to endothelial decompensation (primarily Fuch's dystrophy or pseudophakic/aphakic corneal edema) and 410 patients underwent penetrating keratoplasty (PKP).

After one year, the researchers found that the regraft rate was similar for the DSAEK and PKP groups (2.3 versus 1.3 percent). However, endothelial cell loss was significantly higher in the DSAEK group (38 versus 20 percent). Among patients who underwent PKP, endothelial cell loss was significantly higher for patients with pseudophakic/aphakic corneal edema than Fuch's dystrophy, while endothelial cell loss was similar for the two conditions in patients who underwent DSAEK.

"One year post-transplantation, overall graft success was comparable for DSAEK and PKP procedures and endothelial cell loss was higher with DSAEK," Price and colleagues conclude.

One author reported receiving travel grants from Moria.

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