ASBMR: Cell Purification Technique Aids Bone Healing

New technology uses bone marrow to increase stem cells

MONDAY, Sept. 25 (HealthDay News) -- A mixture of cells derived from bone marrow and processed with new technology to increase the production of stem and early-stage cells may promote healing in difficult-to-treat fractures, according to research presented at the 28th annual meeting of the American Society for Bone and Mineral Research in Philadelphia.

Janet Hock, Ph.D., an employee and stockholder of Aastrom Biosciences in Ann Arbor, Mich., the company that developed the technology, and clinical investigators harvested bone marrow from 36 patients with severe or non-healing fractures and cultured the cells in a closed, computer-controlled system for 12 days. The cells were implanted in the patients during open surgery.

The formation of bony callus was seen in 78 percent of patients at three months and in 91 percent at six months. Of 12 patients who completed the one-year follow-up, 10 had bone bridging at the healing fracture site.

"The cell purification technique used in these studies provides a system for accelerating the rate and efficiency of fracture repair in patients with severe or poorly healing fractures," said ASBMR president-elect Steve Goldring, M.D., in a statement.


Physician's Briefing