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Drug Found Effective During Spinal Deformity Surgery

Aprotinin reduces blood loss and transfusion requirements compared to tranexamic acid

THURSDAY, Jan. 21 (HealthDay News) -- In adult patients undergoing lumbar pedicle subtraction osteotomy, treatment with aprotinin may be associated with significantly less blood loss than treatment with tranexamic acid, according to a study in the Jan. 15 issue of Spine.

Christine R. Baldus, R.N., of Washington University in St. Louis, and colleagues studied 44 patients, including 14 treated with aprotinin, 20 treated with tranexamic acid, and 10 controls.

The researchers found that mean intraoperative blood loss was significantly lower in the aprotinin group (1,114 ml) than in the tranexamic acid and control groups (2,102 ml and 2,260 ml, respectively). They also found the mean blood received during surgery was significantly lower in the aprotinin group (577 ml) than in the tranexamic acid and controls groups (1,838 ml and 1,502 ml, respectively). They observed no significant group differences in intra- and post-operative complications.

"These results may justify further study of aprotinin and other antifibrinolytics for this specific indication (three-column lumbar osteotomies in the adult spinal deformity population)," the authors conclude. "A multicenter randomized comparative analysis would be ideal."

This study was supported by Medtronic; one or more of the authors reported financial relationships with a commercial party related directly or indirectly to the subject of the manuscript.

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