Bone Biomarkers Change Following Spinal Cord Injury

Markers show uncoupling of osteoblastic, osteoclastic activity and bone density

Bone Biomarkers Change Following Spinal Cord Injury

FRIDAY, July 18, 2014 (HealthDay News) -- Following chronic, traumatic spinal cord injury (SCI), some bone biomarkers undergo noticeable changes, according to a study published in the July 1 issue of The Spine Journal.

Hadis Sabour, M.D., Ph.D., from the Tehran University of Medical Sciences in Iran, and colleagues determined bone biomarker changes in patients with chronic SCI. Patients self-reported accident and demographic information, while physiologic measures were determined using spinal magnetic resonance imaging, physical examination, dual-energy X-ray absorptiometry (to determine bone mineral density in femoral and spinal vertebrae bone sites), and blood analysis (including C-telopeptide cross-linked Type 1 collagen [CTX], parathyroid hormone, calcitonin, osteocalcin, and bone alkaline phosphatase [BALP]).

The researchers observed a negative association between CTX level and bone mineral density in femoral and spinal bone sites, confirming that CTX is a bone resorption marker. There were no significant correlations with post-injury duration and either CTX or BALP levels. There was a positive association between CTX and osteocalcin and BALP (P < 0.0001). Osteocalcin was positively associated with BALP (P < 0.0001).

"Our data also support this fact that although bone reduction after two years is slower than acute phase after SCI, bone resorption rate is higher than bone formation," the authors write.

Full Text (subscription or payment may be required)

Physician's Briefing