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BMD and FRAX Score Tied to Fracture Risk in Diabetes

Older adults with type 2 diabetes mellitus have a higher fracture risk for a given FRAX, T score

TUESDAY, May 31 (HealthDay News) -- In older adults with type 2 diabetes mellitus (DM), bone mineral density (BMD) T score and age or World Health Organization Fracture Risk Algorithm (FRAX) score are associated with increased fracture risk, according to a study published in the June 1 issue of the Journal of the American Medical Association.

Ann V. Schwartz, Ph.D., from the University of California in San Francisco, and colleagues examined the association between femoral neck BMD T score and the FRAX score and hip and nonspine fracture risk in older adults with type 2 DM. Data from 9,449 women and 7,436 men in three observational studies with adjudicated fracture outcomes were analyzed. Of the participants, 770 women and 1,199 men had type 2 DM.

The investigators found that for a one-unit decrease in BMD T score the age-adjusted hazard ratio (HR) for women was 1.88 for hip fracture and 1.52 for nonspine fractures, and for men it was 5.71 for hip fracture and 2.17 for nonspine fractures. The FRAX score was also significantly correlated with fracture risk in participants with DM (HR for one-unit increase in FRAX score, 1.05 for women and 1.09 for men). Compared to participants without DM, those with DM had an increased fracture risk for a given T score and age, or for a given FRAX score.

"Femoral neck BMD T score and FRAX score are both associated with fracture risk in older adults with type 2 DM," the authors write. "However, a given T score or FRAX score is associated with a higher risk of fracture in older adults with DM compared with those without DM."

Several authors disclosed financial ties with multiple pharmaceutical companies.

Abstract
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