See What HealthDay Can Do For You
Contact Us

Research Suggests Broader Role for HPV in HNSCC Etiology

HPV-16 and other HPVs, including γ11- and γ12-HPV species and β1-HPV-5 type, all implicated


MONDAY, Jan. 25, 2016 (HealthDay News) -- Human papillomavirus (HPV)-16 detection is tied to incidence of oropharyngeal squamous cell carcinoma (SCC); and other HPVs, including γ11- and γ12-HPV species and β1-HPV-5 type, are also associated with head and neck squamous cell carcinoma (HNSCC), according to a study published online Jan. 21 in JAMA Oncology.

Ilir Agalliu, M.D., Sc.D., from the Albert Einstein College of Medicine in Bronx, N.Y., and colleagues conducted a nested case-control study among 96,650 participants who were cancer free at baseline with available mouthwash samples in two prospective cohort studies. During an average of 3.9 years follow-up in both cohorts, 132 incident cases of HNSCC were identified; three controls were selected per case (396 controls).

The researchers found that oral HPV-16 detection correlated with incident HNSCC (odds ratio [OR], 7.1), with a positive correlation for oropharyngeal SCC (OR, 22.4) but not for oral cavity or laryngeal SCC. Detection of β1-HPV-5, β2-HPV-38 types and γ11 and γ12 species correlated with increased odds of HNSCC (ORs ranged from 2.64 to 5.45; P < 0.01 for all comparisons). β1-HPV-5 type correlated with oropharyngeal, oral cavity, and laryngeal SCCs (ORs, 7.42, 5.34, and 2.71, respectively), while γ11- and γ12-HPV species correlated with both oral cavity (ORs, 7.47 and 6.71, respectively) and laryngeal SCCs (ORs, 7.49 and 5.31, respectively).

"This study demonstrates that HPV-16 detection precedes the incidence of oropharyngeal SCC," the authors write. "Associations of other HPVs, including γ11- and γ12-HPV species and β1-HPV-5 type suggest a broader role for HPVs in HNSCC etiology."

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.