Endoscopic Sinus Surgery Helpful for Chronic Sinusitis

Study finds quality of life improves, especially after first-time surgery

WEDNESDAY, Jan. 6 (HealthDay News) -- Most patients with chronic rhinosinusitis (CRS) benefit significantly from endoscopic sinus surgery, according to a study in the January issue of Otolaryngology -- Head and Neck Surgery.

Timothy L. Smith, M.D., of Oregon Health & Science University in Portland, and colleagues conducted a study of 302 patients with CRS who were treated surgically and followed up for a mean 17.4 months.

After surgery, there was an average 15.8 percent improvement on the Rhinosinusitis Disability Index and a 21.2 percent improvement on the Chronic Sinusitis Survey, the researchers found. Over 70 percent of patients with poor baseline quality of life saw an improvement after surgery, according to both scales, the investigators discovered, while those undergoing surgery for the first time were 2.1 times more likely than their counterparts undergoing revision surgery to have an improvement on the Rhinosinusitis Disability Index and 1.8 times more likely to show improvement on the Chronic Sinusitis Survey.

"Certain clinical phenotypes, such as CRS associated with asthma, CRS associated with acetylsalicylic acid intolerance, and CRS associated with prior sinus surgery, were significant in the univariate screening of predictors of quality of life outcomes, but, among these, history of prior sinus surgery appears to be most predictive," the authors write. "Preliminary analyses suggested that mucosal inflammatory markers provide important predictive information and deserve further investigation."

Smith is a consultant for Sinexus Inc.

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