Squirt System Best Way to Apply Nasal Dysfunction Drugs
A squirt system delivered blue dye more effectively than more commonly used nasal drops and sprays
WEDNESDAY, June 18 (HealthDay News) -- Sinonasal disease patients' poor response to treatment with corticosteroids may be due to the way therapies are applied, according to a paper published in the June 16 issue of the Archives of Otolaryngology -- Head & Neck Surgery.
Mandy Scheibe, M.D., of the University of Dresden Medical School in Dresden, Germany, and colleagues tested three kinds of drug delivery systems for sinonasal disease treatments in a blinded study conducted at a university hospital research unit. Blue food dye was applied to the nasal cavities of 15 volunteers using one of three methods: nasal drops applied with a pipette, nasal spray, or a nasal squirt system. Independent observers measured the intranasal distribution of the dye.
Nasal squirts are likely to have the highest efficacy in treating sinonasal diseases because they deliver substances more effectively to the olfactory cleft than nasal drops or sprays, the researchers found. Of the three application methods, only the squirt system delivered the dye to olfactory cleft in the majority of patients; the nasal drops reached the nasal floor, and the nasal spray was distributed to the nasal mucosa, but did not reach the olfactory cleft.
"The present data suggest that previous failure of therapy with topical application of corticosteroids in patients with sinonasal olfactory loss may, at least in part, be due to the fact that the substances did not reach the olfactory cleft when using traditional applicators," the researchers conclude. "When using a squirt system, however, it appears more likely that larger amounts of the drugs reach the olfactory epithelium."