Here are what the editors at HealthDay consider to be the most important developments in Pathology for February 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Personalized Tumor Biomarkers Monitor Treatment Efficacy
FRIDAY, Feb. 26 (HealthDay News) -- Personalized tumor-specific biomarkers based on the chromosomal rearrangements present in an individual patient can be detected with high sensitivity in blood and used to monitor the efficacy of treatment in cancer patients, according to a study in the Feb. 24 issue of Science Translational Medicine.
Abstract
Full Text (subscription or payment may be required)
Peripheral Arterial Disease Location Impacts Prognosis
FRIDAY, Feb. 26 (HealthDay News) -- The general prognosis in patients with peripheral arterial disease (PAD) is worse in those with proximal disease than those with more distal disease, according to research published in the March 2 issue of the Journal of the American College of Cardiology.
Abstract
Full Text (subscription or payment may be required)
Annual Colonoscopy Helpful for High-Risk Cancer Group
THURSDAY, Feb. 25 (HealthDay News) -- Annual colonoscopies can provide timely detection of early-stage colorectal cancer (CRC) in the high-risk group of people with the genetic condition known as hereditary nonpolyposis colorectal cancer (HNPCC), according to a study in the February issue of Clinical Gastroenterology and Hepatology.
Abstract
Full Text (subscription or payment may be required)
Model Predicts Risk of Prostate Cancer After Negative Biopsy
THURSDAY, Feb. 25 (HealthDay News) -- A model that takes changes in risk factors over time into account can predict who is at high risk of developing prostate cancer among men whose biopsies are initially negative, according to a study published online Feb. 22 in the Journal of Clinical Oncology.
Abstract
Full Text (subscription or payment may be required)
Biomarkers Suboptimal for Early Liver Cancer Detection
WEDNESDAY, Feb. 24 (HealthDay News) -- Two biomarkers are less effective than ultrasound in detecting early liver cancer in high-risk patients with advanced hepatitis C, according to a study in the February issue of Gastroenterology.
Abstract
Full Text
Physicians Working Fewer Hours for Lower Fees
TUESDAY, Feb. 23 (HealthDay News) -- Physicians in the United States have been working fewer hours for lower fees in the past decade, according to research published in the Feb. 24 issue of the Journal of the American Medical Association.
Abstract
Full Text (subscription or payment may be required)
Chemical Tags May Be Key in Metabolic Regulation
MONDAY, Feb. 22 (HealthDay News) -- Acetylation has an important role in the regulation of metabolism, with nearly all enzymes involved in a variety of processes in the human liver found to be acetylated, according to research published in the Feb. 19 issue of Science. The researchers state these findings provide novel clues on how normal cells function and may lead to information on why normal cells turn cancerous.
Abstract
Full Text (subscription or payment may be required)
Mouse Experiment Finds New Biomarkers for Lupus Nephritis
MONDAY, Feb. 22 (HealthDay News) -- The elevation of total urinary protease and several urinary proteins may offer novel biomarkers in the diagnosis of lupus nephritis, according to a mouse study in the Feb. 15 issue of the Journal of Immunology.
Abstract
Full Text (subscription or payment may be required)
Cell-Free DNA Integrity May Serve as Marker in Kidney Cancer
MONDAY, Feb. 22 (HealthDay News) -- Serum cell-free DNA (cf-DNA) integrity may serve as a predictive marker for the diagnosis and detection of clear renal cell carcinoma (cRCC), according to a study in the February issue of Urology.
Abstract
Full Text (subscription or payment may be required)
Infectious Disease Not Linked to Future Celiac Disease
MONDAY, Feb. 22 (HealthDay News) -- Children with an infectious disease at the time of gluten introduction do not appear to have an increased risk of developing celiac disease, according to a study published online Feb. 22 in Pediatrics.
Abstract
Full Text (subscription or payment may be required)
Hormone Level of Little Help in Predicting Parathyroid Surgery
FRIDAY, Feb. 19 (HealthDay News) -- Baseline intact parathyroid hormone (iPTH) levels don't appear useful for deciding whether to perform parathyroidectomy in patients with primary hyperparathyroidism (PHPT), according to research published in the February issue of the Archives of Otolaryngology -- Head & Neck Surgery.
Abstract
Full Text (subscription or payment may be required)
Gene Variant Associated With Premenstrual Syndrome
FRIDAY, Feb. 19 (HealthDay News) -- Female mice with a common variant of a gene affected by estrogen levels are more anxious and have impaired memory, according to a study published online Feb. 8 in the Proceedings of the National Academy of Sciences. The findings could explain behavioral changes occurring during the menstrual cycle associated with conditions such as premenstrual syndrome.
Abstract
Full Text (subscription or payment may be required)
Tobacco Use Linked to HPV+ Oropharynx Cancer Recurrence
FRIDAY, Feb. 19 (HealthDay News) -- In patients with advanced human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx (SCCOP) who achieve a complete response to chemoradiation therapy, current smokers are at higher risk of disease recurrence and tend to have worse disease-specific survival, according to a study published online Feb. 15 in Clinical Cancer Research.
Abstract
Full Text (subscription or payment may be required)
New System Aims to Improve Blood Transfusion Safety
FRIDAY, Feb. 19 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has started a national surveillance system to monitor adverse events in patients who receive blood transfusions, the agency has announced.
Press Release
Drug Addition Found to Reduce Multiple Sclerosis Activity
THURSDAY, Feb. 18 (HealthDay News) -- The addition of daclizumab to interferon beta treatment reduces brain lesion formation in patients with relapsing multiple sclerosis, possibly by increasing the number of a subset of natural killer cells, according to a study published online Feb. 16 in The Lancet Neurology.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Breast Cancer Decline Linked to Hormone Therapy Decline
THURSDAY, Feb. 18 (HealthDay News) -- The rise and fall in U.S. breast cancer rates from 1992 to 2005 mainly reflects affluent white (non-Hispanic) women initially adopting then abandoning hormone replacement therapy (HRT) because of its breast cancer risk, according to a study published online Feb. 10 in the American Journal of Public Health.
Abstract
Full Text (subscription or payment may be required)
Genetic Risk Scores Not Linked to Cardiovascular Disease
TUESDAY, Feb. 16 (HealthDay News) -- Comprehensive literature-based genetic risk scores do not improve the prediction of cardiovascular risk among Caucasian women, according to research published in the Feb. 17 issue of the Journal of the American Medical Association.
Abstract
Full Text (subscription or payment may be required)
Chronic Conditions Becoming More Common in Children
TUESDAY, Feb. 16 (HealthDay News) -- Chronic health conditions have become increasingly more common in children in recent decades, according to research published in the Feb. 17 issue of the Journal of the American Medical Association.
Abstract
Full Text
Editorial (subscription or payment may be required)
Genomic Markers Linked to Heart Disease
TUESDAY, Feb. 16 (HealthDay News) -- Single-nucleotide polymorphisms in chromosome 9p21 are associated with heart disease, particularly in younger people, according to research published in the Feb. 17 issue of the Journal of the American Medical Association.
Abstract
Full Text (subscription or payment may be required)
Modest Genetic Differences Seen in Streptococcus Strains
TUESDAY, Feb. 16 (HealthDay News) -- Group A Streptococcus strains from successive epidemics have relatively modest genetic differences but very different global gene expression, which may provide clues about their biology, according to a study published online Feb. 8 in the Proceedings of the National Academy of Sciences.
Abstract
Full Text (subscription or payment may be required)
Superficial Venous Thrombosis May Herald Greater Risks
TUESDAY, Feb. 16 (HealthDay News) -- Given that many patients with superficial venous thrombosis (SVT) also have deep venous thrombosis (DVT) at presentation, and a considerable number develop thromboembolic complications in following months, SVT may be more of a concern than previously thought, according to research published in the Feb. 16 issue of the Annals of Internal Medicine.
Abstract
Full Text (subscription or payment may be required)
Outcomes Found to Be Poor in South Carolina Stroke Patients
TUESDAY, Feb. 16 (HealthDay News) -- In South Carolina, patients hospitalized for an initial stroke have an elevated short- and long-term risk of recurrent stroke, heart attack, vascular death, and all-cause death, according to a study in the Feb. 16 issue of Neurology.
Abstract
Full Text (subscription or payment may be required)
Cardiac Effects of Hormone Replacement Therapy Studied
TUESDAY, Feb. 16 (HealthDay News) -- Hormone replacement therapy that includes estrogen plus progestin may not reduce the risk for coronary heart disease (CHD) during the first several years of treatment in women who started hormone therapy near menopause, according to research published in the Feb. 16 issue of the Annals of Internal Medicine.
Abstract
Full Text (subscription or payment may be required)
Effect of Cigar, Pipe Smoke on Lung Function Assessed
TUESDAY, Feb. 16 (HealthDay News) -- Cigar and pipe smoking have been linked with higher urine cotinine levels and airflow obstruction, even in those who have never smoked cigarettes, according to research published in the Feb. 16 issue of the Annals of Internal Medicine.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Metastatic Prostate Cancer Mechanism Identified
MONDAY, Feb. 15 (HealthDay News) -- An oncogene tumor-suppressor cascade may drive metastatic prostate cancer, according to research published online Feb. 14 in Nature Medicine.
Abstract
Full Text (subscription or payment may be required)
Keeping Vaccination Records Linked to Greater Compliance
MONDAY, Feb. 15 (HealthDay News) -- When parents had children's vaccination records available, children were more likely to be up-to-date on their vaccinations, according to research published online Feb. 15 in Pediatrics.
Abstract
Full Text (subscription or payment may be required)
Severe Sleep Apnea Linked to Fewer Nightmares
MONDAY, Feb. 15 (HealthDay News) -- Patients with severe obstructive sleep apnea (OSA) report fewer nightmares, according to a study in the Feb. 15 issue of the Journal of Clinical Sleep Medicine.
Abstract
Full Text (subscription or payment may be required)
Rapid H1N1 Flu Test Found to Be of Limited Value in Children
MONDAY, Feb. 15 (HealthDay News) -- In the diagnosis of pediatric H1N1 influenza A virus infection, the rapid influenza diagnostic test has poor sensitivity but excellent specificity, according to a study published online Feb. 15 in Pediatrics.
Abstract
Full Text (subscription or payment may be required)
Treating Herpes May Slow HIV in Co-Infected Patients
MONDAY, Feb. 15 (HealthDay News) -- In patients co-infected with HIV-1 and herpes simplex virus type 2, treating the herpes infection with acyclovir likely delays the progression of HIV, according to a study published online Feb. 15 in The Lancet.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Seminal Plasma, Not Cells May Be Key to HIV Transmission
MONDAY, Feb. 15 (HealthDay News) -- In HIV infection resulting from men having sex with men (MSM), the infection is likely transmitted via HIV RNA in the plasma constituent of semen, not by the HIV DNA located in seminal cells, according to a study in the Feb. 10 issue of Science Translational Medicine.
Abstract
Full Text (subscription or payment may be required)
Lifestyle Changes Found to Improve Endothelial Function
MONDAY, Feb. 15 (HealthDay News) -- Lifestyle changes such as a low-fat diet and regular exercise improve endothelial function and inflammatory markers of atherosclerosis in patients with coronary artery disease (CAD), according to a study published in the Feb. 1 issue of the American Journal of Cardiology.
Abstract
Full Text (subscription or payment may be required)
2009 H1N1-Related Deaths and Hospitalizations Examined
MONDAY, Feb. 15 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has provided updated estimates of the 2009 H1N1 cases, related hospitalizations and deaths, with approximately 57 million cases occurring between April 2009 and January 2010.
More Information
Study Suggests Treatment Target for Enlarged Tonsils
FRIDAY, Feb. 12 (HealthDay News) -- Phosphoserine phosphatase (PSPH) may play a role in tonsil enlargement in children with obstructive sleep apnea (OSA), and may serve as a target for treating this enlargement, according to research published online Jan. 21 in the American Journal of Respiratory and Critical Care Medicine.
Abstract
Full Text (subscription or payment may be required)
Eating Walnuts May Improve Diabetic Endothelial Function
FRIDAY, Feb. 12 (HealthDay News) -- A diet rich in walnuts helps type 2 diabetes patients improve endothelium-dependent vasodilatation, and may in turn reduce their overall cardiac risk, according to a study published in the February issue of Diabetes Care.
Abstract
Full Text (subscription or payment may be required)
Stenosis Can Still Exist in Absence of Coronary Calcium
FRIDAY, Feb. 12 (HealthDay News) -- In contradiction of professional guidelines, the absence of coronary calcification in blood vessels does not rule out the potential existence of stenosis, and should not be used to decide if revascularization is needed, according to a study in the Feb. 16 issue of the Journal of the American College of Cardiology.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Emotional Stress Can Trigger Acute Coronary Syndrome
FRIDAY, Feb. 12 (HealthDay News) -- Emotional stress, such as that experienced by a spectator at a major sporting event, can increase serum levels of inflammatory biochemicals that can trigger an acute coronary syndrome (ACS) event, according to a study in the Feb. 16 issue of the Journal of the American College of Cardiology.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
MRI Benefit in Breast Cancer Risk Assessment Questioned
FRIDAY, Feb. 12 (HealthDay News) -- Using magnetic resonance imaging (MRI) in addition to the usual triple assessment for breast cancer diagnosis does not reduce the risk of repeat operation and is not a good use of resources, according to a study published in the Feb. 13 issue of The Lancet.
Abstract
Full Text (subscription or payment may be required)
Camp Mumps Outbreak Sickens Over 1,500 People
FRIDAY, Feb. 12 (HealthDay News) -- An outbreak of mumps that began at a summer camp in New York in June 2009 has since infected 1,521 people in New York and New Jersey as of the end of January 2010, according to an article published in the Feb. 12 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Full Text
BP Drugs, Retinal Vessel Diameter in Diabetes Studied
THURSDAY, Feb. 11 (HealthDay News) -- In patients with type 1 diabetes mellitus who have normal blood pressure, neither angiotensin-converting enzyme inhibitors nor angiotensin-receptor blockers have an effect on retinal arteriole or venule diameter, according to a study in the February issue of the Archives of Ophthalmology.
Abstract
Full Text (subscription or payment may be required)
Gout Associated With Higher Heart Attack Risk in Women
THURSDAY, Feb. 11 (HealthDay News) -- Gout is associated with an increased risk of heart attack in women, as previously observed in men, although the risk is higher in women, according to a study published online Feb. 2 in the Annals of the Rheumatic Diseases.
Abstract
Full Text (subscription or payment may be required)
Protein May Block Letrozole Therapy in Breast Cancer
THURSDAY, Feb. 11 (HealthDay News) -- The overexpression of low-molecular-weight cyclin E (LMW-E) in the tumors of many menopausal women with estrogen-receptor-positive (ER+) breast cancers nullifies the effects of letrozole, an aromatase inhibitor. However, letrozole's effect can be restored by adding the cyclin-dependent kinase 2 (CDK2) inhibitor roscovitine to treatment, according to a study published online Feb. 9 in Clinical Cancer Research.
Abstract
Full Text (subscription or payment may be required)
Lactation May Protect Women Against Metabolic Syndrome
THURSDAY, Feb. 11 (HealthDay News) -- Longer duration of breast-feeding can help women, particularly those who developed gestational diabetes mellitus, by reducing their risk of developing the metabolic syndrome, according to a study in the February issue of Diabetes
Abstract
Full Text (subscription or payment may be required)
Systemic Treatment Deemed Effective for Giant-Cell Tumor
THURSDAY, Feb. 11 (HealthDay News) -- Denosumab, an antibody that targets cells involved in bone destruction, is the first systemic treatment shown to be effective in treating giant-cell tumor, a rare osteolytic tumor that can metastasize to the lung, according to a study published online Feb. 10 in The Lancet Oncology.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Myocarditis Linked to Pandemic H1N1 Flu in Children
THURSDAY, Feb. 11 (HealthDay News) -- Several cases of fulminant myocarditis, a rare complication of viral infection, have been identified among children infected with H1N1 pandemic influenza during a one month period, according to the results of a retrospective chart review published online Feb. 10 in the Journal of the American College of Cardiology.
Full Text
Dietary Supplement Suspected of Causing Selenium Poisoning
THURSDAY, Feb. 11 (HealthDay News) -- A liquid dietary supplement that contained 200 times the labeled concentration of selenium caused a widespread outbreak of selenium poisoning affecting 201 people in 10 states, according to a study published in the Feb. 8 issue of the Archives of Internal Medicine.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Migraine Associated With Cardiovascular Events, Risk
THURSDAY, Feb. 11 (HealthDay News) -- Migraines -- both with and without aura -- are associated with a higher risk of cardiovascular events and risk factors for cardiovascular disease, according to research published online Feb. 10 in Neurology.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Magnesium Found Beneficial for Postmenopausal Women
THURSDAY, Feb. 11 (HealthDay News) -- In postmenopausal women, increased magnesium intake is associated with lower levels of some markers of systemic inflammation and endothelial dysfunction, according to a study in the February issue of Diabetes Care.
Abstract
Full Text (subscription or payment may be required)
Study Finds Link Between Genetic Variations, Stuttering
WEDNESDAY, Feb. 10 (HealthDay News) -- Some cases of stuttering may be related to variations in genes that play a role in lysosomal metabolism, according to research published online Feb. 10 in the New England Journal of Medicine.
Abstract
Full Text
Editorial
Youth Cardiovascular Risk Factors Linked to Early Death
WEDNESDAY, Feb. 10 (HealthDay News) -- Cardiovascular risk factors in childhood are associated with a higher rate of premature death from endogenous causes, according to research published in the Feb. 11 issue of the New England Journal of Medicine.
Abstract
Full Text
Editorial
Draft Diagnostic Criteria for DSM-5 Are Released
WEDNESDAY, Feb. 10 (HealthDay News) -- Proposed revisions to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) were released Feb. 10 by the American Psychiatric Association.
More Information
AHRQ: U.S. Adults Seeing Big Barriers to Specialty Care
WEDNESDAY, Feb. 10 (HealthDay News) -- In 2007, about one in 13 of U.S. adults reported that access to specialist care was a "big problem," according to a December report issued by the Agency for Healthcare Research and Quality (AHRQ).
Full Text
FDA Initiative Aims to Cut Medical Radiation Exposure
WEDNESDAY, Feb. 10 (HealthDay News) -- The U.S. Food and Drug Administration has launched a new initiative that aims to reduce exposure to radiation from computed tomography (CT), nuclear medicine studies and fluoroscopy, the three procedures that are the main sources of medically-related radiation exposure.
Press Release
More Information
Bedside Blood Test Found to Detect Anticoagulation Status
WEDNESDAY, Feb. 10 (HealthDay News) -- A new bedside blood test can be used to determine the sufficiency of anticoagulation in patients who are about to undergo catheterization or percutaneous coronary intervention (PCI), according to a study in the Feb. 16 issue of the Journal of the American College of Cardiology.
Abstract
Full Text (subscription or payment may be required)
Neutralizing Antibodies to Interferon Beta May Persist
WEDNESDAY, Feb. 10 (HealthDay News) -- After cessation of interferon beta therapy for relapsing-remitting multiple sclerosis, neutralizing antibodies to interferon beta can persist, and their presence is associated with poorer clinical outcomes, according to a study published online Feb. 8 in the Archives of Neurology.
Abstract
Full Text
Pathway Activation Profiles Linked to Cancer Survival
TUESDAY, Feb. 9 (HealthDay News) -- In patients with non-small cell lung cancer (NSCLC), particular oncogenic pathway activation profiles are associated with recurrence-free survival, and these profiles vary depending on the age and gender of the individual, according to research published in the Feb. 10 issue of the Journal of the American Medical Association.
Abstract
Full Text (subscription or payment may be required)
New Research Points to Threat in Thirdhand Tobacco Smoke
TUESDAY, Feb. 9 (HealthDay News) -- Nicotine left on surfaces from tobacco smoke can combine with ambient nitrous oxide to create carcinogens, raising new concern over the health effects of so-called thirdhand smoke, according to research published online Feb. 8 in the Proceedings of the National Academy of Sciences.
Abstract
Full Text
Paroxetine May Compromise the Efficacy of Tamoxifen
TUESDAY, Feb. 9 (HealthDay News) -- Women with breast cancer who take tamoxifen and the antidepressant paroxetine (Paxil), which has been hypothesized to reduce the effectiveness of tamoxifen, may be at higher risk of dying of breast cancer, according to research published online Feb. 8 in BMJ.
Abstract
Full Text
Editorial (subscription or payment may be required)
Older Maternal Age Linked to Incidence of Type 1 Diabetes
TUESDAY, Feb. 9 (HealthDay News) -- A small percentage of older mothers may be more likely to give birth to children with type 1 diabetes, according to a meta-analysis published in the February issue of Diabetes.
Abstract
Full Text (subscription or payment may be required)
Age-Related Treatment and Outcomes in Stroke Examined
TUESDAY, Feb. 9 (HealthDay News) -- Older people who suffer ischemic stroke are more likely to die in the hospital than younger stroke victims, though disparities in care by age group have been reduced or eliminated in recent years, according to a study published online Feb. 8 in Circulation.
Abstract
Full Text (subscription or payment may be required)
CD Increases Knowledge, Comfort With Genetic Testing
TUESDAY, Feb. 9 (HealthDay News) -- A CD-based educational aid can increase knowledge of and comfort with genetic testing in patients at high risk of developing cancer, and may facilitate informed consent, according to a study published online Feb. 8 in the Journal of Clinical Oncology.
Abstract
Full Text (subscription or payment may be required)
Outcomes Improving in Asymptomatic Carotid Stenosis
TUESDAY, Feb. 9 (HealthDay News) -- In patients with asymptomatic carotid stenosis (ACS), intensive medical therapy has significantly reduced microemboli on transcranial Doppler as well as cardiovascular events, according to a study in the February issue of the Archives of Neurology.
Abstract
Full Text (subscription or payment may be required)
Needle Length May Affect Vaccination Results in Obese
TUESDAY, Feb. 9 (HealthDay News) -- The reduced immune response seen in obese adolescents and adults following hepatitis B virus (HBV) vaccination may be due in part to insufficient needle penetration of muscle, according to research published online Feb. 8 in Pediatrics.
Abstract
Full Text (subscription or payment may be required)
H1N1 Vaccination Still Highly Recommended
MONDAY, Feb. 8 (HealthDay News) -- Despite H1N1 virus levels stabilizing, transmission remains an issue and vaccination continues to be an effective option for prevention of this potentially serious condition, according to a Feb. 5 press briefing by the U.S. Centers for Disease Control.
More Information
Many American Adults Do Not Get Recommended Vaccines
MONDAY, Feb. 8 (HealthDay News) -- Although most parents ensure their children are vaccinated, adults often do not receive recommended vaccinations themselves, according to a new report, Adult Immunization: Shots to Save Lives.
More Information
Physical Inactivity, Not Just Lack of Exercise, Harms Health
FRIDAY, Feb. 5 (HealthDay News) -- Sedentary behavior and a lack of whole-body movement are independent predictors of increased mortality and increased incidence of obesity, diabetes, heart disease and cancer, regardless of level of physical exercise, according to an article published online Feb. 4 in the British Journal of Sports Medicine.
Abstract
Full Text (subscription or payment may be required)
FDA Warns of Link Between Natalizumab, Brain Infection
FRIDAY, Feb. 5 (HealthDay News) -- On Feb. 5, the U.S. Food and Drug Administration notified health care professionals and patients that the risk of developing a rare but serious brain infection increases as the number of natalizumab (Tysabri) infusions received increases.
More Information
Coalition Launches Campaign to Limit Residents' Hours
FRIDAY, Feb. 5 (HealthDay News) -- To prevent medical errors caused by doctor fatigue, a coalition of public interest and patient safety groups is urging the Accreditation Council for Graduate Medical Education (ACGME) to limit the amount of time residents must work without sleep to 16 hours and to increase resident supervision.
www.wakeupdoctor.org
More Information
Study Assesses Survival in Patients With Liver Disease
FRIDAY, Feb. 5 (HealthDay News) -- Individuals with nonalcoholic steatohepatitis (NASH) or nonalcoholic fatty liver disease (NAFLD) have a higher risk of death than the general population, according to research published in the February issue of Hepatology.
Abstract
Full Text
Editorial
GAD Antibodies Linked to Increased Risk of Diabetes
FRIDAY, Feb. 5 (HealthDay News) -- Individuals are more likely to develop diabetes if they produce high levels of glutamic acid decarboxylase antibodies (GADAs), regardless of a family history of diabetes, according to a study in the February issue of Diabetes.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Cyclin D2 Shows Role in β-Cell Expansion in Mouse Model
FRIDAY, Feb. 5 (HealthDay News) -- The cell cycle protein cyclin D2 appears necessary for β-cell mass to expand in response to insulin resistance, suggesting that it may be useful in preventing or curing type 2 diabetes, according to research published online Jan. 26 in Diabetes.
Abstract
Full Text (subscription or payment may be required)
Health Care Spending Makes Record Leap in GDP Share
THURSDAY, Feb. 4 (HealthDay News) -- A growth in health spending in 2009, coupled with a sagging economy, created the largest one-year jump in health care's share of the nation's gross domestic product since 1960, according to an article published online Feb. 4 in Health Affairs.
Abstract
Full Text
No Rebound Seen in Platelet Aggregation After Clopidogrel
THURSDAY, Feb. 4 (HealthDay News) -- There was no rebound in platelet aggregation (PA) observed in cardiovascular patients who stopped taking clopidogrel abruptly or tapered off the medication gradually after the prescribed course of treatment, according to a study in the Feb. 9 issue of the Journal of the American College of Cardiology.
Abstract
Full Text (subscription or payment may be required)
Positive Dipstick Heme Results Appear to Need More Scrutiny
THURSDAY, Feb. 4 (HealthDay News) -- Patients testing positive on dipstick heme tests should have confirmation with microscopic urinalysis before they're further evaluated or referred to a urologist, according to research published in the February issue of The Journal of Urology.
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Editorial (subscription or payment may be required)
Air Quality Found to Affect the Prevalence of Ear Infections
THURSDAY, Feb. 4 (HealthDay News) -- During the past decade, improved air quality has corresponded with a decreased prevalence of frequent ear infections in children, according to a report in the February issue of Otolaryngology -- Head and Neck Surgery.
Abstract
Full Text (subscription or payment may be required)
Worldwide Burden of Retinal Vein Occlusion Evaluated
THURSDAY, Feb. 4 (HealthDay News) -- Retinal vein occlusion may affect 16.4 million adults worldwide, according to an article in the February issue of Ophthalmology.
Abstract
Full Text (subscription or payment may be required)
Diversity Growth Incremental in the Medical Professions
THURSDAY, Feb. 4 (HealthDay News) -- One hundred years after the Flexner Report recommended closing five of the seven African-American medical schools then extant, African-Americans and other minorities remain grossly underrepresented in the medical professions, according to an article in the February issue of Academic Medicine.
Abstract
Full Text (subscription or payment may be required)
Lower Serum Vitamin D Levels Linked to Asthma Severity
WEDNESDAY, Feb. 3 (HealthDay News) -- Lung function tends to be worse and glucocorticoid response poorer in asthma patients who have lower serum levels of vitamin D, according to a study published online Jan. 14 in the American Journal of Respiratory and Critical Care Medicine.
Abstract
Full Text (subscription or payment may be required)
Vendors of Imaging Equipment Urged to Allow Tracked Exposure
WEDNESDAY, Feb. 3 (HealthDay News) -- Due to the increasing exposure to diagnostic radiation, vendors of imaging equipment should allow tracking of radiation exposure, according to an opinion article in the February Journal of the American College of Radiology. A related opinion in the same issue notes that diagnostic radiation exposure has the potential to harm not only the individual but also future generations through processes such as epigenetics.
Full Text - Neumann (subscription or payment may be required)
Full Text - Farooki (subscription or payment may be required)
Role of Artemin in Endometrial Cancer Investigated
WEDNESDAY, Feb. 3 (HealthDay News) -- Endometrial tumors that produce high levels of artemin are more oncogenic and invasive, according to a study published online Jan. 29 in Endocrinology.
Abstract
Full Text (subscription or payment may be required)
The Lancet Retracts Study Linking MMR Vaccine, Autism
WEDNESDAY, Feb. 3 (HealthDay News) -- On Feb. 2, The Lancet retracted a controversial 1998 study that linked the measles, mumps and rubella (MMR) vaccine to autism and gastrointestinal problems.
Retraction
Hippocampal Volume Found to Increase With Aerobic Exercise
WEDNESDAY, Feb. 3 (HealthDay News) -- Aerobic exercise can increase the volume of the hippocampus in schizophrenia patients, and may have a role in the treatment of disabilities associated with the condition, according to a study in the February issue of the Archives of General Psychiatry.
Abstract
Full Text (subscription or payment may be required)
Xiaflex Approved for Rare Hand Condition
WEDNESDAY, Feb. 3 (HealthDay News) -- Collagenase clostridium histolyticum (Xiaflex) has been approved by the U.S. Food and Drug Administration as the first drug to treat a disabling hand condition called Dupuytren's contracture.
U.S. Food and Drug Administration
Growth Hormone Deficiency Not Found to Affect Lifespan
WEDNESDAY, Feb. 3 (HealthDay News) -- Isolated growth hormone deficiency (IGHD) has no effect on longevity once the individual reaches adulthood, according to research published in the February issue of the Journal of Clinical Endocrinology & Metabolism.
Abstract
Full Text (subscription or payment may be required)
Anticoagulation and Risk of VTE Studied in Suspected DVT
TUESDAY, Feb. 2 (HealthDay News) -- In patients with suspected lower extremity deep vein thrombosis (DVT), those with a negative whole-leg compression ultrasound (CUS) and no anticoagulation therapy are at low risk of venous thromboembolism, according to a meta-analysis reported in the Feb. 3 issue of the Journal of the American Medical Association.
Abstract
Full Text (subscription or payment may be required)
Lower Brain Serotonin Seen in Infants Who Died of SIDS
TUESDAY, Feb. 2 (HealthDay News) -- Lower levels of medullary serotonin in infants who died of sudden infant death syndrome (SIDS) suggest that a serotonin deficiency may play a role in the condition, according to research published in the Feb. 3 issue of the Journal of the American Medical Association.
Abstract
Full Text (subscription or payment may be required)
Cognitive Test May Predict Brain Infarction in Elderly Men
TUESDAY, Feb. 2 (HealthDay News) -- In elderly men, impaired performance on a cognitive test is an independent predictor of brain infarction, according to a study published in the Feb. 2 issue of Neurology.
Abstract
Full Text (subscription or payment may be required)
Androgen Deprivation Therapy and Cardiac Risk Link Assessed
TUESDAY, Feb. 2 (HealthDay News) -- The use of androgen deprivation therapy (ADT) to treat prostate cancer may be associated with cardiovascular risk, according to an article published online Feb. 1 in Circulation.
Abstract
Full Text
Late Mortality May Be Decreasing in Childhood Cancer Survivors
TUESDAY, Feb. 2 (HealthDay News) -- Late mortality among five-year survivors of childhood cancer has dropped significantly in the past few decades, largely due to fewer deaths from recurrence or progression, according to a study published online Feb. 1 in the Journal of Clinical Oncology. In a related study in the same issue, researchers report that the expression of 34 genes predicts outcomes in patients with rhabdomyosarcoma.
Abstract - Armstrong
Full Text (subscription or payment may be required)
Abstract - Davicioni
Full Text (subscription or payment may be required)
Estrogen Levels Linked to Breast Cancer Gene Expression
TUESDAY, Feb. 2 (HealthDay News) -- Plasma estrogen levels are correlated with the expression of estrogen-dependent genes in estrogen receptor (ER)-positive breast cancers, according to a study published online Feb. 1 in the Journal of Clinical Oncology.
Abstract
Full Text (subscription or payment may be required)
President Proposes $911 Billion Budget for HHS
TUESDAY, Feb. 2 (HealthDay News) -- As part of his 2011 budget proposal, President Barack Obama has proposed $911 billion for the U.S. Health and Human Services (HHS) Department, according to a Feb. 1 announcement by the secretary of HHS, Kathleen Sebelius.
More Information
Transplant Type Found to Have No Effect on Leukemia Survival
MONDAY, Feb. 1 (HealthDay News) -- In leukemia patients, long-term survival rates are similar in those who were transplanted with either peripheral blood stem cells or bone marrow, according to a study published online Feb. 1 in The Lancet Oncology.
Abstract
Full Text (subscription or payment may be required)
Antioxidants Found to Alter Muscle Oxygen Use in Rats
MONDAY, Feb. 1 (HealthDay News) -- Antioxidants alter the pattern of oxygen delivery and consumption in resting and contracting muscle in aged rats, according to recent studies at Kansas State University, including research originally published in the December 2008 issue of the Journal of Applied Physiology.
Abstract
Full Text
Adrenal Condition's Effects on Women's Fertility Studied
MONDAY, Feb. 1 (HealthDay News) -- Women with nonclassical congenital adrenal hyperplasia (NC-CAH) due to 21-hydroxylase deficiency have only mild fertility problems, but clinicians should consider treating them with glucocorticoids to lower their risk of miscarriage, according to a study published online Jan. 15 in the Journal of Clinical Endocrinology & Metabolism.
Abstract
Full Text (subscription or payment may be required)
