See What HealthDay Can Do For You
Contact Us

February 2012 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for February 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Inactivity and Obesity Relate to Cognitive Impairment in Lupus

WEDNESDAY, Feb. 29 (HealthDay News) -- Physical inactivity and obesity are associated with impaired cognitive function, especially executive functions, in women with systemic lupus erythematosus (SLE), according to research published online Feb. 15 in Arthritis Care & Research.

Abstract
Full Text (subscription or payment may be required)

Family Tree Clarifies Risk of Death Due to Arrhythmia

WEDNESDAY, Feb. 29 (HealthDay News) -- In six inherited arrhythmia syndromes, the Family Tree Mortality Ratio (FTMR) method is useful for identifying the age during which mortality risk becomes manifest in an untreated population, according to research published online Feb. 28 in Circulation: Cardiovascular Genetics.

Abstract
Full Text (subscription or payment may be required)

Rapid Flu Tests Effective for Ruling In (But Not Out) Diagnosis

TUESDAY, Feb. 28 (HealthDay News) -- Rapid influenza tests are useful for diagnosing influenza; and oral oseltamivir and inhaled zanamivir may be beneficial for the treatment of influenza, according to two reviews published online Feb. 27 in the Annals of Internal Medicine.

Abstract - Chartrand
Full Text (subscription or payment may be required)
Abstract - Hsu
Full Text (subscription or payment may be required)

Red Blood Cell Omega-3 Levels Linked to Brain Volume

MONDAY, Feb. 27 (HealthDay News) -- In adults without clinical dementia, low red blood cell (RBC) levels of omega-3 fatty acids are associated with smaller brain volumes and lower scores on tests of visual memory and executive function, according to a study published in the Feb. 28 issue of Neurology.

Abstract
Full Text (subscription or payment may be required)

Ten-Year CML Survival Estimate of 68 Percent With Imatinib

MONDAY, Feb. 27 (HealthDay News) -- For patients with chronic myeloid leukemia that fails to respond to interferon alpha therapy, treatment with imatinib is associated with long-term survival of 68 percent, according to a study published online Feb. 27 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Human Ovaries Contain Oocyte-Producing Stem Cells

MONDAY, Feb. 27 (HealthDay News) -- Human ovaries contain rare mitotically active stem cells that can be purified and used to generate oocytes, as has been previously shown in mice, according to a study published online Feb. 26 in Nature Medicine.

Abstract
Full Text (subscription or payment may be required)

Body Clock Linked to Sudden Cardiac Death

FRIDAY, Feb. 24 (HealthDay News) -- A body clock-dependent protein is associated with variations in electrical stability in the heart, which may explain why people are at higher risk of sudden cardiac death in the morning, according to research published online Feb. 22 in Nature.

Abstract
Full Text (subscription or payment may be required)

Oncogenic HPV Rarely Present in Breast Cancer Tissues

FRIDAY, Feb. 24 (HealthDay News) -- Contrary to numerous reports, oncogenic human papillomavirus (HPV) types are rarely present in mammary epithelium of patients with breast cancer, according to a study published in the March 1 issue of Cancer.

Abstract
Full Text (subscription or payment may be required)

Prevalence of Screening for Lynch Syndrome Varies

THURSDAY, Feb. 23 (HealthDay News) -- Screening for Lynch syndrome, the most common form of inherited colorectal cancer, after a colorectal cancer diagnosis is common at comprehensive cancer centers but not community hospitals, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial

Assay, Algorithm Promising for Detection of Trisomies 21, 18

THURSDAY, Feb. 23 (HealthDay News) -- A novel biochemical assay (Digital Analysis of Selected Regions [DANSR]) combined with an algorithm (Fetal-fraction Optimized Risk of Trisomy Evaluation [FORTE]) accurately identifies the risk of fetal trisomy 21 and 18 from maternal-blood cell-free DNA (cfDNA), according to two studies published online Jan. 27 in the American Journal of Obstetrics & Gynecology.

Abstract - Sparks
Full Text
Abstract - Ashoor
Full Text

Family History Ups Risk of Differentiated Thyroid Cancer

THURSDAY, Feb. 23 (HealthDay News) -- Family history of thyroid cancer in a first-degree relative may be associated with an increased risk of sporadic differentiated thyroid carcinoma (DTC), according to a study published in the March 1 issue of Cancer.

Abstract
Full Text (subscription or payment may be required)

Bisphosphonate Use Linked to Reduced Colorectal Cancer Risk

THURSDAY, Feb. 23 (HealthDay News) -- Exposure to bisphosphonates (BPs) is associated with a reduction in the risk of colorectal cancer (CRC), a reduction that is significant only for risedronic acid, according to a study published in the March 1 issue of Cancer.

Abstract
Full Text (subscription or payment may be required)

Elevated Homocysteine, Heart Disease Link Questioned

WEDNESDAY, Feb. 22 (HealthDay News) -- Elevated homocysteine levels are not associated with a greater risk of coronary heart disease when considering unpublished data, suggesting publication bias, according to a study available online Feb. 21 in PLoS Medicine.

Abstract
Full Text (subscription or payment may be required)

Endometriosis Linked to Higher Ovarian Cancer Risk

WEDNESDAY, Feb. 22 (HealthDay News) -- A history of endometriosis increases the risk of developing ovarian cancer, although the increased risk is restricted to specific subtypes of invasive ovarian cancer, according to a meta-analysis published online Feb. 22 in The Lancet Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

High VEGF Signaling Score Tied to Lung Cancer Prognosis

WEDNESDAY, Feb. 22 (HealthDay News) -- A high vascular endothelial growth factor (VEGF) signaling score correlates with good prognosis in patients with early squamous cell carcinoma (SCC) of the lung, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Highest Diabetes Death Rates Seen in Trials Selecting for CKD

WEDNESDAY, Feb. 22 (HealthDay News) -- In type 2 diabetes patients selected for randomized controlled trials (RCTs), chronic kidney disease (CKD) is associated with the highest overall risk of mortality, according to a review published online Feb. 21 in the Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease.

Abstract
Full Text (subscription or payment may be required)

C-Peptide Still Produced After Decades of Diabetes

WEDNESDAY, Feb. 22 (HealthDay News) -- Some patients who have had type 1 diabetes for decades can still produce C-peptide and respond to hyperglycemia, suggesting residual β-cell function, according to a study published in the March issue of Diabetes Care.

Abstract
Full Text

Dermatologist Density Linked to Melanoma Mortality Rates

TUESDAY, Feb. 21 (HealthDay News) -- Melanoma mortality rates are significantly lower in U.S. counties with 0.001 to 2.0 dermatologists per 100,000 people, compared to those with no dermatologist, according to a study published in the February issue of the Archives of Dermatology.

Abstract
Full Text (subscription or payment may be required)

By 2007, Hep C Superseded HIV As Cause of Death in U.S.

MONDAY, Feb. 20 (HealthDay News) -- Hepatitis C virus (HCV) superseded HIV as a cause of death by 2007; and birth cohort screening is cost-effective for HCV, according to two studies published in the Feb. 21 issue of the Annals of Internal Medicine.

Abstract - Ly
Full Text (subscription or payment may be required)
Abstract - Rein
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

White Matter Changes Precede Manifestations of Autism

MONDAY, Feb. 20 (HealthDay News) -- The development of white matter pathways is abnormal in infants before manifestations of autism spectrum disorders (ASDs), according to a study published online Feb. 17 in the American Journal of Psychiatry.

Abstract
Full Text

Normal Breast Protein Linked to Cancer Development

MONDAY, Feb. 20 (HealthDay News) -- Trefoil (TFF3) protein, which maintains the integrity of the epithelial surface in the normal breast, is highly expressed in well-differentiated tumors, correlating with low histological grade, and also has an expression profile which is consistent with a role in breast cancer progression and metastasis, according to a study published in the March issue of The American Journal of Pathology.

Abstract
Full Text (subscription or payment may be required)

X-Chromosome Gene Variant Linked to SIDS in Boys

MONDAY, Feb. 20 (HealthDay News) -- A gene variant on the X-chromosome is associated with sudden infant death syndrome (SIDS) only in boys, particularly those who die at the ages of highest SIDS prevalence, according to a study published online Feb. 20 in Pediatrics.

Abstract
Full Text (subscription or payment may be required)

Lipid Sensor GPR120 Linked to Obesity in Mice and Humans

MONDAY, Feb. 20 (HealthDay News) -- A protein that acts as a lipid sensor, GPR120, can lead to obesity when defective in mice and humans, according to a study published online Feb. 19 in Nature.

Abstract
Full Text (subscription or payment may be required)

Cell Abnormality Linked to Diabetic Retinopathy

FRIDAY, Feb. 17 (HealthDay News) -- Type 1 diabetes patients with early retinopathy have abnormalities in their endothelial progenitor cells (EPC), a cell type released into the circulation as a result of vascular damage, according to a study published online Feb. 14 in Diabetes.

Abstract
Full Text (subscription or payment may be required)

High Uric Acid Level Predictive of Adverse Cardiac Events

FRIDAY, Feb. 17 (HealthDay News) -- A high serum uric acid level is an independent predictor of in-hospital and long-term adverse cardiac events in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), according to research published in the Feb. 15 issue of The American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

Pregnancy Complications Tied to CVD Later in Life

FRIDAY, Feb. 17 (HealthDay News) -- Pregnancy-related complications, including hypertensive disorders and diabetes, may identify women at increased risk of cardiovascular disease (CVD) later in life, according to a study published online Feb. 17 in Circulation.

Abstract
Full Text (subscription or payment may be required)

MRI Alone Not Ideal in Pulmonary Embolism Diagnosis

FRIDAY, Feb. 17 (HealthDay News) -- Magnetic resonance imaging (MRI) should not be used as a stand-alone test to diagnose pulmonary embolism (PE), according to a study published online Feb. 9 in the Journal of Thrombosis and Haemostasis.

Abstract
Full Text (subscription or payment may be required)

Open-Angle Glaucoma Linked to Erectile Dysfunction

FRIDAY, Feb. 17 (HealthDay News) -- Men with erectile dysfunction (ED) are almost three times more likely to have been previously diagnosed with glaucoma, according to a study published in the February issue of Ophthalmology.

Abstract
Full Text

Ectopic Pregnancy Death Rate Spikes in Florida

THURSDAY, Feb. 16 (HealthDay News) -- Although Florida's rate of ectopic pregnancy-related deaths was on a par with that of the rest of the nation in 2008, about 0.6 deaths per 100,000 births, the number jumped to 2.5 per 100,000 in 2009 to 2010, according to research published in the Feb. 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

Full Text

Chickens Harbor E. coli Found in Human UTIs

THURSDAY, Feb. 16 (HealthDay News) -- Retail purchased chicken may be the source of extraintestinal pathogenic Escherichia coli (ExPEC) that causes urinary tract infections (UTIs) in humans, according to a study published online Feb. 15 in Emerging Infectious Diseases.

Full Text

Autism Spectrum Disorders Linked to Motor Impairment

THURSDAY, Feb. 16 (HealthDay News) -- Motor skills are impaired in children with autism spectrum disorders (ASD), and this impairment correlates with autistic severity and IQ, according to a study published online in Autism.

Abstract
Full Text (subscription or payment may be required)

Thrombopoietic Cytokine Circuit Fuels Ovarian Tumor Growth

THURSDAY, Feb. 16 (HealthDay News) -- In patients with ovarian cancer and in a related mouse model, a paracrine loop involving increased hepatic thrombopoietin and tumor-derived interleukin-6 increases platelet counts and promotes tumor growth, according to a study published in the Feb. 16 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)

TTN Mutation Detection Aids Cardiomyopathy Diagnosis

THURSDAY, Feb. 16 (HealthDay News) -- Adding sequencing approaches that detect genetic mutations in the TTN gene, which codes for the sarcomere protein titin, would enable earlier diagnosis and improved treatment for patients with dilated cardiomyopathy, according to a study published in the Feb. 16 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)

High Levels of Genital HLA-G Linked With HIV-1 Infection

THURSDAY, Feb. 16 (HealthDay News) -- High genital levels of soluble HLA-G (sHLA-G), a powerful modulator of the immune response, are associated with HIV-1 infection in Beninese commercial sex workers (CSWs), according to a study published online in PLoS One.

Full Text

Topical Corticosteroids Impair Restoration of Skin Barrier

WEDNESDAY, Feb. 15 (HealthDay News) -- Topical corticosteroids offer a more potent anti-inflammatory effect for the treatment of atopic dermatitis (AD), but they may impair the restoration of the skin barrier and can induce skin atrophy, making topical calcineurin inhibitors more suitable for long-term treatment of the disease, according to a study published in the March issue of Allergy.

Abstract
Full Text (subscription or payment may be required)

Inactivating Mutation in KISS1 Prevents Pubertal Progression

WEDNESDAY, Feb. 15 (HealthDay News) -- An inactivating mutation has been identified in the KISS1 gene in a consanguineous family, a mutation that results in failure of pubertal progression, according to a report published in the Feb. 16 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)

Biomarker Linked to Arthritis Severity at Hip but Not Knee

WEDNESDAY, Feb. 15 (HealthDay News) -- A new biomarker is associated with osteoarthritis severity at the hip but not the knee, according to a study published in the Feb. 10 issue of the Journal of Biological Chemistry.

Abstract
Full Text (subscription or payment may be required)

Anti-apoA-1 Ups Cardiovascular Risk Prediction in RA

WEDNESDAY, Feb. 15 (HealthDay News) -- Adding the biomarker anti-apolipoprotein A-1 IgG (anti-apoA-1) to the 10-year Framingham cardiovascular risk score (FRS) significantly improves prediction of cardiovascular events in patients with rheumatoid arthritis, according to a study published online Feb. 2 in Arthritis Care & Research.

Abstract
Full Text (subscription or payment may be required)

Air Pollutant Exposure Tied to Increased Heart Attack Risk

TUESDAY, Feb. 14 (HealthDay News) -- Short-term exposure to all major air pollutants, except for ozone, is significantly associated with an increased risk of heart attack, according to a study published in the Feb. 15 issue of the Journal of the American Medical Association.

Abstract
Full Text (subscription or payment may be required)

Lynch Syndrome Linked to Increased Risk of Many Cancers

TUESDAY, Feb. 14 (HealthDay News) -- Patients with Lynch syndrome, an inherited disorder of cancer susceptibility caused by mutations in a mismatch repair (MMR) gene, face significantly increased risks of a variety of cancers, including breast and pancreatic cancer, according to a study published online Feb. 13 in the Journal of Clinical Oncology.

Abstract
Full Text

Pollutant Exposure Tied to Cognitive Decline in Elderly

TUESDAY, Feb. 14 (HealthDay News) -- Long-term exposure to particulate matter (PM) (coarse PM: 2.5 to 10 µm in diameter [PM2.5-10] and fine PM: <2.5 µm in diameter [PM2.5]) is associated with faster cognitive decline in older women, according to a study published in the Feb. 13 issue of the Archives of Internal Medicine.

Abstract
Full Text (subscription or payment may be required)

Cardiac Stem Cell Infusion After Myocardial Infarction Safe

TUESDAY, Feb. 14 (HealthDay News) -- Intracoronary infusion of cardiosphere-derived cells (CDCs) after myocardial infarction (MI) is safe and improves cardiac function, according to a phase 1 study published online Feb. 14 in The Lancet.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

New Staging System IDs cSCC Risk in Transplant Patients

TUESDAY, Feb. 14 (HealthDay News) -- The newly updated seventh edition American Joint Committee on Cancer (AJCC) staging system accurately predicts the risk of recurrence of cutaneous squamous cell carcinoma (cSCC) in high-risk heart and lung transplant recipients, according to a study published online Jan. 30 in the Journal of the American Academy of Dermatology.

Abstract
Full Text (subscription or payment may be required)

Digital Colposcopy Enhances Cervical Cancer Detection

TUESDAY, Feb. 14 (HealthDay News) -- Dynamic spectral imaging (DSI) colposcopy is more sensitive for detecting cervical intraepithelial neoplasia (CIN2+) in women who are human papillomavirus type 16-positive (HPV16+) than for women who are non-16 high-risk (hr) HPV+, according to a study published online Feb. 3 in BJOG: An International Journal of Obstetrics and Gynaecology.

Abstract
Full Text (subscription or payment may be required)

Increases in [18F]FDDNP Tied to Future Cognitive Decline

MONDAY, Feb. 13 (HealthDay News) -- For individuals without dementia, increases in 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([18F]FDDNP) positron emission tomography (PET) binding in brain regions are associated with future cognitive decline, according to a study published in the February issue of the Archives of Neurology.

Abstract
Full Text (subscription or payment may be required)

Lipid Genetics Linked to Type 2 Diabetes Risk

MONDAY, Feb. 13 (HealthDay News) -- Individuals who are genetically predisposed to have low levels of high-density lipoprotein (HDL) cholesterol or high levels of triglycerides have an increased risk of developing type 2 diabetes, according to a study published online Feb. 7 in Diabetes.

Abstract
Full Text (subscription or payment may be required)

Prenatal Stress May Affect Infant Immune System

FRIDAY, Feb. 10 (HealthDay News) -- A woman's prenatal exposure to high stress and dust mite allergens may interact to affect the immune system of her offspring, according to a study published online Feb. 6 in Allergy.

Abstract
Full Text (subscription or payment may be required)

Nanotubes and Hyperthermia Kill Breast Cancer Stem Cells in Mice

FRIDAY, Feb. 10 (HealthDay News) -- Injecting carbon nanotubes into breast cancer stem cell-driven tumors followed by hyperthermia with a laser is highly effective in killing these tumors that are normally resistant to conventional hyperthermia, according to a study published in the April issue of Biomaterials.

Abstract
Full Text (subscription or payment may be required)

Dermoscopy Aids Diagnosis of Inflammatory Skin Conditions

FRIDAY, Feb. 10 (HealthDay News) -- Inflammatory skin conditions, including plaque psoriasis (PP), dermatitis, lichen planus (LP), and pityriasis rosea (PR), each exhibit a characteristic dermoscopic pattern, according to a study published online Feb. 1 in the British Journal of Dermatology.

Abstract
Full Text (subscription or payment may be required)

Software Helps Resolve Complex DNA Sequence Data

FRIDAY, Feb. 10 (HealthDay News) -- A new software program can help resolve complex DNA sequencing data more quickly and easily than other methods, according to a study published online Feb. 10 in The Journal of Molecular Diagnostics.

Abstract
Full Text (subscription or payment may be required)

Sudomotor Denervation Found in Diabetic Neuropathy

FRIDAY, Feb. 10 (HealthDay News) -- Sudomotor denervation has been demonstrated in individuals with diabetic neuropathy, and the sweat gland innervation index (SGII) correlates with glycated hemoglobin (HbA1c) levels, according to research published online Feb. 1 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Inflammation Link With Stroke Depends on Stroke Type

THURSDAY, Feb. 9 (HealthDay News) -- Elevated leukocyte counts are associated with a higher incidence of cerebral infarction and a lower incidence of intracerebral hemorrhage, according to a study published online Feb. 3 in the Journal of Internal Medicine.

Abstract
Full Text (subscription or payment may be required)

Acute Myeloid Leukemia Risk Factors ID'd in Texas Adults

THURSDAY, Feb. 9 (HealthDay News) -- Solvent exposure, smoking, and obesity are significant risk factors for de novo acute myeloid leukemia (AML) in Texas, according to a study published online Feb. 1 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Fasting Augments Chemo in Cancer Cells, Mouse Models

THURSDAY, Feb. 9 (HealthDay News) -- Short cycles of starvation (fasting) sensitizes mammalian cancer cells to chemotherapeutic agents, and may increase the effectiveness of chemotherapy against cancer cells and in mouse models, according to an experimental study published online Feb. 8 in Science Translational Medicine.

Abstract
Full Text (subscription or payment may be required)

Gene Therapy for Blindness Safe in Second Eye

WEDNESDAY, Feb. 8 (HealthDay News) -- For patients with a hereditary form of blindness previously treated with gene therapy in one eye, a second dose of gene therapy in the other eye is safe and improves vision even further, according to a study published in the Feb. 8 issue of Science Translational Medicine.

Abstract
Full Text (subscription or payment may be required)

Parkin Has Key Role in Human Nigral Dopaminergic Neurons

WEDNESDAY, Feb. 8 (HealthDay News) -- Parkin may control dopamine utilization in the human midbrain by enhancing dopaminergic neurotransmission and suppressing dopamine oxidation, according to a study published online Feb. 7 in Nature Communications.

Abstract
Full Text (subscription or payment may be required)

Caffeine Reduces Fibrosis Risk in Nonalcoholic Liver Disease

WEDNESDAY, Feb. 8 (HealthDay News) -- Coffee caffeine consumption (CC) substantially reduces the risk of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD), according to a study published in the February issue of Hepatology.

Abstract
Full Text (subscription or payment may be required)

Soy Isoflavones Don't Reduce Breast Epithelial Proliferation

WEDNESDAY, Feb. 8 (HealthDay News) -- Mixed soy isoflavone supplements given over a six-month period show no significant effect in reducing the proliferation of breast cancer epithelial cells in healthy women, according to a study published in the February issue of Cancer Prevention Research.

Abstract
Full Text (subscription or payment may be required)

Fructose Stimulates Insulin Via Sweet Taste Receptors

TUESDAY, Feb. 7 (HealthDay News) -- Fructose binds to sweet taste receptors (TRs) on beta cells, activating a signaling pathway that potentiates glucose-stimulated insulin secretion, according to an experimental study published online Feb. 6 in the Proceedings of the National Academy of Sciences.

Abstract
Full Text (subscription or payment may be required)

Subcortical Gray Matter Changes Seen in RA Patients

TUESDAY, Feb. 7 (HealthDay News) -- Compared with healthy control subjects, patients with rheumatoid arthritis (RA) have reduced intracranial volumes and structural changes in the subcortical gray matter, but do not have localized cortical gray matter atrophy, according to research published in the February issue of Arthritis & Rheumatism.

Abstract
Full Text (subscription or payment may be required)

Mechanism for Metabolic Effects of Resveratrol Elucidated

MONDAY, Feb. 6 (HealthDay News) -- By inhibiting phosphodiesterase (PDE) 4 in skeletal muscle, resveratrol triggers a series of intracellular events, including indirect activation of sirtuin 1 (Sirt1), according to an experimental study published in the Feb. 3 issue of Cell.

Abstract
Full Text

Massage Reduces Inflammation Following Hard Exercise

MONDAY, Feb. 6 (HealthDay News) -- Massage therapy following strenuous exercise reduces inflammation and promotes the growth of new mitochondria in skeletal muscle, according to a study published in the Feb. 1 issue of Science Translational Medicine.

Abstract
Full Text (subscription or payment may be required)

Noroviruses Are Leading Cause of Hospital Infections

MONDAY, Feb. 6 (HealthDay News) -- Norovirus outbreaks are the leading cause of infection outbreaks in hospitals, particularly in the non-acute care setting, and often lead to unit closure, according to an article published in the February issue of the American Journal of Infection Control.

Abstract
Full Text (subscription or payment may be required)

Same Gene Variants in Early- and Late-Onset Alzheimer's

FRIDAY, Feb. 3 (HealthDay News) -- Rare variants of three genes linked to early-onset Alzheimer's disease can also be found in individuals with late-onset Alzheimer's disease, suggesting that mutations are not the only factor affecting age of onset, according to a study published online Feb. 1 in PloS One.

Full Text (subscription or payment may be required)

New Assay IDs Individuals With Major Depressive Disorder

FRIDAY, Feb. 3 (HealthDay News) -- A multi-assay, serum-based test can be used to distinguish individuals with major depressive disorder (MDD) from controls, with high specificity and sensitivity, according to a study published online Dec. 13 in Molecular Psychiatry.

Abstract
Full Text (subscription or payment may be required)

Prostate Size Predicts Gleason Score Upgrading

FRIDAY, Feb. 3 (HealthDay News) -- For men with low-risk prostate cancer, prostate size is an independent predictor of Gleason score upgrading, according to a study published in the December issue of The Journal of Urology.

Abstract
Full Text (subscription or payment may be required)

Alanine Aminotransferase Levels ID Liver Disease Risk

FRIDAY, Feb. 3 (HealthDay News) -- Alanine aminotransferase (ALT) levels can be used to discriminate between individuals infected with hepatitis C virus (HCV) RNA and those at low risk for liver disease (negative HCV RNA and hepatitis B surface antigen, low alcohol consumption, no evidence of diabetes, and normal body mass index and waist circumference), according to a study published in the February issue of Hepatology.

Abstract
Full Text (subscription or payment may be required)

Personalized Liver Cells Support Hepatitis C Virus

THURSDAY, Feb. 2 (HealthDay News) -- Liver-like cells produced from an individual's own cells can support the entire life cycle of hepatitis C virus, potentially making it possible to study why people respond differently to the virus, according to a study published online Jan. 30 in the Proceedings of the National Academy of Sciences.

Abstract
Full Text (subscription or payment may be required)

Reconstruction of Words From Brain Waves Feasible

THURSDAY, Feb. 2 (HealthDay News) -- Words can be reconstructed from neural activity in the superior temporal gyrus (STG), according to a study published online Jan. 31 in PLoS Biology.

Abstract
Full Text

Genetic Variants in Melatonin Receptor Linked to Diabetes

THURSDAY, Feb. 2 (HealthDay News) -- Rare variants of the melatonin receptor 1B (MTNR1B) gene are associated with a higher risk of type 2 diabetes, according to a study published online Jan. 29 in Nature Genetics.

Abstract
Full Text (subscription or payment may be required)

Heart Failure Linked to Loss of Cerebral Gray Matter

THURSDAY, Feb. 2 (HealthDay News) -- Heart failure is associated with loss of gray matter (GM) in the brain and worse cognitive function, according to a study published online Jan. 31 in the European Heart Journal.

Abstract
Full Text

β-Amyloid Deposition Seen in Some Healthy Older Adults

THURSDAY, Feb. 2 (HealthDay News) -- Elevated β-amyloid (Aβ) deposition is seen in some healthy older adults and is associated with worse cognitive performance, according to a study published online Feb. 1 in Neurology.

Abstract
Full Text (subscription or payment may be required)

Geographic Pattern of Lyme Disease Mapped in Eastern U.S.

THURSDAY, Feb. 2 (HealthDay News) -- Two Lyme disease risk foci have been identified in the Northeast and upper Midwest of the United States, according to a study published in the February issue of The American Journal of Tropical Medicine and Hygiene.

Abstract
Full Text

Live Liver Donation Doesn't Impact Long-Term Mortality

WEDNESDAY, Feb. 1 (HealthDay News) -- The risk of early death for live liver donors is 1.7 per 1,000 donors, and long-term mortality is similar to that of healthy individuals, according to a study published in the February issue of Gastroenterology.

Abstract
Full Text
Editorial

Insulin Secretion Impaired in the Insulin-Resistant

WEDNESDAY, Feb. 1 (HealthDay News) -- Individuals with impaired glucose tolerance or type 2 diabetes have impaired glucose-stimulated insulin secretion after exposure to insulin compared with healthy individuals, according to a study published in the February issue of Diabetes.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Repeat Flexible Sigmoidoscopy Increases Detection of CRC

WEDNESDAY, Feb. 1 (HealthDay News) -- Repeated screening by flexible sigmoidoscopy (FSG) increases the detection of colorectal cancer or advanced adenoma in women and men, according to a study published online Jan. 31 in the Journal of the National Cancer Institute.

Abstract
Full Text (subscription or payment may be required)
Editorial

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.