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January 2020 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for January 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Girls May Receive First Autism Diagnosis Later Than Boys

FRIDAY, Jan. 31, 2020 (HealthDay News) -- Among people with autism spectrum disorder (ASD), girls often receive a first diagnosis of autism later than boys, according to a study published online Jan. 20 in Autism Research.

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CDC Releases First Data on Maternal Mortality Since 2007

FRIDAY, Jan. 31, 2020 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention National Center for Health Statistics has released the first national data on maternal mortality since 2007. The data are presented in three National Vital Statistics Reports.

Report 1
Report 2
Report 3

In Early Stages, Novel 2019 Coronavirus Doubling Every 7.4 Days

FRIDAY, Jan. 31, 2020 (HealthDay News) -- In the early stages, the novel 2019 coronavirus (2019-nCoV)-infected pneumonia (NCIP) epidemic doubled in size every 7.4 days, according to a study published online Jan. 29 in the New England Journal of Medicine.

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2017 to 2018 Saw Increase in Life Expectancy in the United States

THURSDAY, Jan. 30, 2020 (HealthDay News) -- From 2017 to 2018, there was an increase in life expectancy in the United States and a decrease in age-adjusted death rates, according to a January data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.

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Nitrite Consumption May Up Risk for Non-Hodgkin Lymphoma

THURSDAY, Jan. 30, 2020 (HealthDay News) -- Nitrite consumption is associated with an increased risk for non-Hodgkin lymphoma (NHL), according to a meta-analysis published online Jan. 17 in Scientific Reports.

Abstract/Full Text

Promoting Mixed Chimerism Promising in Kidney Transplants

THURSDAY, Jan. 30, 2020 (HealthDay News) -- For patients undergoing living kidney transplants, persistent mixed chimerism can be achieved to allow complete or partial withdrawal of immunosuppressive drugs, according to a study published in the Jan. 29 issue of Science Translational Medicine.

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Exposure to Diesel Exhaust May Impair Endothelial Function

THURSDAY, Jan. 30, 2020 (HealthDay News) -- Short-term exposure to diesel exhaust fumes has an adverse impact on endothelial function and vascular wall properties, according to a study published online Jan. 29 in the European Journal of Preventive Cardiology.

Abstract/Full Text

U.S. Spends More on Health Care, but Has Worse Life Expectancy

THURSDAY, Jan. 30, 2020 (HealthDay News) -- The United States spends substantially more than any other wealthy nation on health care, yet it has a lower life expectancy and a higher suicide rate than other wealthy nations, according to a January data brief released by the Commonwealth Fund.

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Dietary Flavonols May Reduce Risk for Alzheimer Dementia

WEDNESDAY, Jan. 29, 2020 (HealthDay News) -- Higher dietary intake of flavonols seems to be associated with a reduced risk for incident Alzheimer dementia, according to a study published online Jan. 29 in Neurology.

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Speech Analysis May Help Track Changes in Mental Health State

WEDNESDAY, Jan. 29, 2020 (HealthDay News) -- A system for collecting speech samples from people with serious mental illness can be used to track changes in their clinical states over time, according to a study published online Jan. 15 in PLOS ONE.

Abstract/Full Text

Familial Psoriasis May Not Be Tied to Obesity

WEDNESDAY, Jan. 29, 2020 (HealthDay News) -- Obesity does not necessarily induce or contribute to familial psoriasis, according to a study published online Jan. 17 in the Journal of Dermatology.

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Patients Have Less Dyspnea After Bariatric Surgery for Obesity

WEDNESDAY, Jan. 29, 2020 (HealthDay News) -- Obese individuals undergoing bariatric surgery have improvement in dyspnea, which is associated with less air trapping and end-expiratory tracheal collapse, according to a study published online Jan. 28 in Radiology.

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Gender Gap Persists in Starting Salary for Physicians

TUESDAY, Jan. 28, 2020 (HealthDay News) -- The gender gap in starting salary for physicians persists, although it is unclear which factors account for this gap, according to a report published online Jan. 22 in Health Affairs.

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Coronavirus Deaths Top 100 in China

TUESDAY, Jan. 28, 2020 (HealthDay News) -- As the death toll in China's coronavirus (2019-nCoV) outbreak surpassed 100 on Tuesday, the United States expanded its travel alert and prepared to evacuate American government workers who are in the center of the epidemic.

The New York Times Article
CDC Media Briefing Transcript

Health-Related Quality of Life Lower for Women With PCOS

TUESDAY, Jan. 28, 2020 (HealthDay News) -- Women with polycystic ovary syndrome (PCOS) report low health-related quality of life (HRQoL) beyond the reproductive years, according to a study published online Jan. 23 in the Journal of Clinical Endocrinology & Metabolism.

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Proteinuria After Inpatient Acute Kidney Injury Tied to Later Risk

TUESDAY, Jan. 28, 2020 (HealthDay News) -- Urine albumin-to-creatinine ratio (ACR) measured after acute kidney injury (AKI) predicts subsequent loss of renal function, according to a study published online Jan. 27 in JAMA Internal Medicine.

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Clinical Features ID'd for First 2019 Novel Coronavirus Patients

TUESDAY, Jan. 28, 2020 (HealthDay News) -- As of Jan. 2, 2020, 41 patients were admitted with laboratory-confirmed 2019 novel coronavirus (2019-nCoV), all of whom had pneumonia, according to a study published online Jan. 24 in The Lancet.

Abstract/Full Text
Editorial

Community-Based Diabetes Screening Feasible in Barbershops

MONDAY, Jan. 27, 2020 (HealthDay News) -- Community-based diabetes screening in barbershops owned by black individuals is feasible and can identify undiagnosed diabetes, according to a research letter published online Jan. 27 in JAMA Internal Medicine.

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Wealthy Pay Most to Finance U.S. Health Care

MONDAY, Jan. 27, 2020 (HealthDay News) -- Health care payments in the United States are more regressive than previously thought, according to a study published online Jan. 27 in Health Services Research.

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LV Hypertrophy May Explain Racial Disparities in Heart Failure

MONDAY, Jan. 27, 2020 (HealthDay News) -- A "malignant" subphenotype of left ventricular hypertrophy (LVH) with minimal elevations in cardiac biomarkers is associated with an increased risk for heart failure, with some of the excess risk for heart failure among blacks explained by a higher prevalence of malignant LVH, according to a study published online Jan. 14 in Circulation.

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Updated Guidelines Issued for ER, PgR Testing in Breast Cancer

MONDAY, Jan. 27, 2020 (HealthDay News) -- In an American Society of Clinical Oncology/College of American Pathologists updated guideline, published online Jan. 13 in the Archives of Pathology & Laboratory Medicine and the Journal of Clinical Oncology, recommendations are presented for estrogen and progesterone receptor (ER/PgR) testing in breast cancer.

Abstract/Full Text - Archives of Pathology & Laboratory Medicine
Abstract/Full Text - Journal of Clinical Oncology

High-Dose IV Vitamin C Does Not Speed Resolution of Septic Shock

FRIDAY, Jan. 24, 2020 (HealthDay News) -- Treatment with intravenous vitamin C, hydrocortisone, and thiamine does not improve the duration of time alive and vasopressor administration-free compared with intravenous hydrocortisone alone among patients with septic shock, according to a study published online Jan. 17 in the Journal of the American Medical Association.

Abstract/Full Text
Editorial

Structural Traits of Living Donor Kidneys May Predict Graft Failure

FRIDAY, Jan. 24, 2020 (HealthDay News) -- Structural features of kidneys from living donors may predict death-censored graft failure in recipients, according to a study published online Jan. 23 in the Journal of the American Society of Nephrology.

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First-Biopsy Results for Deceased Donor Kidneys Questioned

THURSDAY, Jan. 23, 2020 (HealthDay News) -- Considerable differences in histologic categorization are seen in sequential biopsies in deceased donor kidneys that undergo multiple procurement biopsies prior to transplantation, according to a study published online Jan. 23 in the Clinical Journal of the American Society of Nephrology.

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CDC: HIV-1/HIV-2 Differentiation Test Increasingly Used in U.S.

THURSDAY, Jan. 23, 2020 (HealthDay News) -- From 2010 to 2017, use of the HIV-1/HIV-2 differentiation test increased, but the number of HIV-2 diagnoses remained very low, according to research published in the Jan. 24 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Supratentorial ICH Outcomes Better in Young Blacks, Hispanics

THURSDAY, Jan. 23, 2020 (HealthDay News) -- For young adults with supratentorial intracerebral hemorrhage (ICH), functional outcomes are improved with black and Hispanic versus white race/ethnicity, according to a study published online Jan. 22 in Neurology.

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Fewer Than Half of Clinical Trials Comply With Reporting Laws

THURSDAY, Jan. 23, 2020 (HealthDay News) -- Compliance with the U.S. Food and Drug Administration Amendments Act of 2007 is low, with only 40.9 percent of trials reporting results within one year, according to a study published online Jan. 17 in The Lancet.

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Editorial (subscription or payment may be required)

High-Fat Milk Consumption Tied to Faster Biological Aging

THURSDAY, Jan. 23, 2020 (HealthDay News) -- People who drink low-fat milk experience less biological aging than those who drink high-fat milk, according to a study recently published in Oxidative Medicine and Cellular Longevity.

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Fast-Track Review of ACA Lawsuit Rejected by U.S. Supreme Court

WEDNESDAY, Jan. 22, 2020 (HealthDay News) -- A fast-track review of a lawsuit that threatens the Affordable Care Act was rejected Tuesday by the U.S. Supreme Court.

AP News Article

Six Active Ingredients of Sunscreen Systemically Absorbed

WEDNESDAY, Jan. 22, 2020 (HealthDay News) -- Sunscreen application is associated with geometric mean maximum plasma concentrations of all six active ingredients that exceed 0.5 ng/mL, according to a study published online Jan. 21 in the Journal of the American Medical Association.

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Anti-Müllerian Hormone Predicts Time to Final Menstrual Period

WEDNESDAY, Jan. 22, 2020 (HealthDay News) -- Measurement of anti-Müllerian hormone (AMH) levels in blood can help predict the time to final menstrual period (FMP), according to a study published online Jan. 22 in the Journal of Clinical Endocrinology & Metabolism.

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ACP: Medicare for All Needed to Fix 'Ill' U.S. Health Care System

TUESDAY, Jan. 21, 2020 (HealthDay News) -- The American College of Physicians (ACP) says the U.S. health care system "is ill and needs a bold new prescription" that includes coverage for all Americans and lower costs.

AP News Article
American College of Physicians

Dasatinib Tops Imatinib for Ph+ Acute Lymphoblastic Leukemia

TUESDAY, Jan. 21, 2020 (HealthDay News) -- Dasatinib is associated with improved survival for pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to a study published online Jan. 16 in JAMA Oncology.

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Editorial (subscription or payment may be required)

Fish Oil Supplement Intake Linked to Better Testicular Function

TUESDAY, Jan. 21, 2020 (HealthDay News) -- For young men, fish oil supplement intake is associated with better testicular function, according to a study published online Jan. 17 in JAMA Network Open.

Abstract/Full Text
Editorial

Troponin Testing May Be Overused in Geriatric Patients

TUESDAY, Jan. 21, 2020 (HealthDay News) -- Routine troponin testing for acute coronary syndrome (ACS) may not be warranted in elderly patients with nonspecific complaints (NSCs) presenting to the emergency department, according to a study published in the January issue of Academic Emergency Medicine.

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Further Improvements in Survival Seen After Allogeneic Transplant

TUESDAY, Jan. 21, 2020 (HealthDay News) -- From 2003-2007 to 2013-2017, there was an improvement in survival for allogeneic hematopoietic cell transplantation, according to a study published online Jan. 21 in the Annals of Internal Medicine.

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Acute Flaccid Myelitis Features Differ in Peak, Nonpeak Years

FRIDAY, Jan. 17, 2020 (HealthDay News) -- Clinical and laboratory characteristics of acute flaccid myelitis (AFM) cases differ in peak and nonpeak years, according to a study published online Jan. 15 in Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.

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Single-Payer System Would Likely Save Money

THURSDAY, Jan. 16, 2020 (HealthDay News) -- There is near consensus across 30 years of economic analysis of single-payer plans that a single-payer system would reduce health expenditures in the United States, according to a review published online Jan. 15 in PLOS Medicine.

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ACA Tied to Narrowing of Disparities in Access to Care

THURSDAY, Jan. 16, 2020 (HealthDay News) -- The Affordable Care Act has reduced disparities in access to health care among black, Hispanic, and white adults, according to a January data brief released by the Commonwealth Fund.

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Maternal Distress May Affect Brain Development in Fetuses With CHD

WEDNESDAY, Jan. 15, 2020 (HealthDay News) -- Psychological distress, including stress, anxiety, and depression, is prevalent among women carrying fetuses with congenital heart disease (CHD), and this distress can affect fetal neurological development, according to a study published online Jan. 13 in JAMA Pediatrics.

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AI System Can Detect, Grade Cancer in Prostate Needle Biopsy

WEDNESDAY, Jan. 15, 2020 (HealthDay News) -- An artificial intelligence (AI) system can be used to detect and grade prostate cancer in prostate needle biopsy samples, according to a study published online Jan. 8 in The Lancet Oncology.

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Enterovirus A71 Outbreak in Children ID'd in Colorado Hospital

WEDNESDAY, Jan. 15, 2020 (HealthDay News) -- In an observational cohort study recently published in The Lancet Infectious Diseases, details are presented for an outbreak of enterovirus A71 (EV-A71) neurological disease in children who presented to a Colorado hospital for treatment.

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Editorial (subscription or payment may be required)

2001 to 2016 Saw Drop, Stall in IQ Losses From Chemicals

TUESDAY, Jan. 14, 2020 (HealthDay News) -- From 2001 to 2016, there was a decrease or stagnation in IQ losses from exposure to polybrominated diphenyl ethers (PBDEs), methylmercury, and lead, according to a study published online Jan. 14 in Molecular and Cellular Endocrinology.

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Vaccine Program Recovery Difficult After Public Scares

TUESDAY, Jan. 14, 2020 (HealthDay News) -- Misinformation in the Danish media between 2013 and 2016 led to a 50.4 percent drop in human papillomavirus (HPV) vaccinations among girls in Denmark, according to a study published online Jan. 7 in Vaccine.

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Doctor Replacement Ratios Higher in Largest, Hospital-Owned Practices

TUESDAY, Jan. 14, 2020 (HealthDay News) -- From 2009 to 2016, more physicians entering the Medicare program worked at large group or hospital-owned practices than small group or independent practices, according to a research letter published online Jan. 14 in the Annals of Internal Medicine.

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Physicians Spend >16 Minutes Per Encounter on EHR Use

MONDAY, Jan. 13, 2020 (HealthDay News) -- Physicians spend a considerable amount of time using electronic health records (EHRs) to support care delivery, with wide variation seen in the distribution of time within specialty, according to a study published online Jan. 14 in the Annals of Internal Medicine.

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Editorial (subscription or payment may be required)

Mortality Risk in Oropharynx Cancer Varies Based on HPV Status

MONDAY, Jan. 13, 2020 (HealthDay News) -- For patients with oropharynx cancer, the rates of head and neck cancer (HNC) mortality and competing mortality vary depending on human papillomavirus (HPV) status, with increased risks for HNC mortality and competing mortality in HPV-negative patients, according to a study published online Jan. 13 in Cancer.

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Guidance Issued for Hepatic, Mesenteric Circulation Disorders

MONDAY, Jan. 13, 2020 (HealthDay News) -- In a clinical guideline from the American College of Gastroenterology, published in the January issue of the American Journal of Gastroenterology, recommendations are presented for management of disorders of the hepatic and mesenteric circulation.

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Incidental Lymphopenia Linked to Increased Risk for Mortality

MONDAY, Jan. 13, 2020 (HealthDay News) -- Incidental lymphopenia is associated with an increased risk for all-cause and cause-specific mortality, according to a study published in the Jan. 13 issue of CMAJ, the journal of the Canadian Medical Association.

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Burnout in Med Students Tied to Perceived Stress, Phone Behavior

MONDAY, Jan. 13, 2020 (HealthDay News) -- Higher levels of perceived stress, poorer sleep quality, and smartphone addiction contribute to burnout in osteopathic medical students, according to a study published in the January issue of the Journal of the American Osteopathic Association.

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California May Start Producing Its Own Medicines

FRIDAY, Jan. 10, 2020 (HealthDay News) -- A proposal for California to contract generic drug companies to make medications would make the state the first in the country to produce its own medications.

AP News Article

15-Year-Old Texas Teen Youngest in U.S. to Die From Vaping

FRIDAY, Jan. 10, 2020 (HealthDay News) -- A 15-year-old Texas teen who died from vaping is the youngest victim so far in an outbreak of vaping-related deaths in the United States.

The New York Times Article
More Information: CDC

Recruitment Satisfactory for Foreign-Educated Health Providers

FRIDAY, Jan. 10, 2020 (HealthDay News) -- Foreign-educated health professionals (FEHPs) in the United States are overall satisfied with their recruitment experience, according to a study published in the January issue of the American Journal of Nursing.

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Neighborhood Disadvantage Impacts Hospital Quality Ratings

FRIDAY, Jan. 10, 2020 (HealthDay News) -- Hospitals caring for neighborhoods with high levels of disadvantage may have lower hospital ratings due to social risk factors (SRFs) in the community, according to a study published online Dec. 30 in Medical Care.

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Metabolic Syndrome May Up Risk for VTE Recurrence After DVT

THURSDAY, Jan. 9, 2020 (HealthDay News) -- For patients with deep vein thrombosis (DVT), the presence of any component of metabolic syndrome (MetS) is independently associated with an increased risk for venous thromboembolism (VTE) recurrence, according to a study published online Jan. 9 in Blood Advances.

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Untreated Oral Infection Not Tied to Stem Cell Transplant Outcomes

THURSDAY, Jan. 9, 2020 (HealthDay News) -- Untreated chronic oral infection is not associated with post-hematopoietic stem cell transplant (HSCT) outcomes, according to a study published online Dec. 18 in PLOS ONE.

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Large Gap Found in Health Administrative Spending for U.S., Canada

WEDNESDAY, Jan. 8, 2020 (HealthDay News) -- There is a large and widening gap in health administrative spending between the United States and Canada, according to a study published online Jan. 7 in the Annals of Internal Medicine.

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Active Lifestyle May Slow Familial Frontotemporal Dementia

WEDNESDAY, Jan. 8, 2020 (HealthDay News) -- A physically and mentally active lifestyle may protect against frontotemporal dementia even in people at established genetic risk, according to a study published in the January issue of Alzheimer's & Dementia.

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HIV+ Patients Lose Immunity to Smallpox Despite Vaccination

WEDNESDAY, Jan. 8, 2020 (HealthDay News) -- HIV-infected patients lose immunity to smallpox despite childhood vaccination and immune reconstitution with antiretroviral therapy, according to a study published online Dec. 23 in The Journal of Infectious Diseases.

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Cancer Mortality Continuing to Drop, With Lung Cancer a Driver

WEDNESDAY, Jan. 8, 2020 (HealthDay News) -- Cancer mortality is continuing to decline, driven by progress in lung cancer, although mortality reductions have slowed or stopped for some cancers, according to findings included in Cancer Statistics, 2020, the American Cancer Society's latest annual report on cancer incidence, mortality, and survival. The report was published online Jan. 8 in CA: A Cancer Journal for Clinicians.

Cancer Statistics, 2020

Low Cardiac Troponin Levels Cannot Safely Rule Out Ischemia

TUESDAY, Jan. 7, 2020 (HealthDay News) -- Even very low concentrations of high-sensitivity cardiac troponin I (hs-cTnI) cannot safely rule out inducible myocardial ischemia in patients with symptomatic coronary artery disease (CAD), according to a study published online Jan. 7 in the Annals of Internal Medicine.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Laser-Based Imaging + AI May Diagnose Brain Tumors in OR

MONDAY, Jan. 6, 2020 (HealthDay News) -- A novel workflow that combines advanced optical imaging with an artificial intelligence algorithm may accurately diagnose brain tumors in real time in the operating room, according to a study published online Jan. 6 in Nature Medicine.

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Many Pelvic Exams, Pap Tests Unnecessary in Teens and Young Adults

MONDAY, Jan. 6, 2020 (HealthDay News) -- More than half of bimanual pelvic examinations (BPEs) and more than 70 percent of Papanicolaou (Pap) tests performed among adolescent girls and women younger than 21 years in the United States are unnecessary, according to a study published online Jan. 6 in JAMA Internal Medicine.

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Editorial (subscription or payment may be required)

Ambient Air Pollution Linked to Lower Bone Mineral Content

FRIDAY, Jan. 3, 2020 (HealthDay News) -- Exposure to ambient particulate matter air pollution with an aerodynamic diameter <2.5 µm (PM2.5) and black carbon (BC) is associated with lower bone mineral content (BMC) in adults, according to a study published online Jan. 3 in JAMA Network Open.

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Routine HPV Testing May Be Warranted for Sinonasal Cancers

FRIDAY, Jan. 3, 2020 (HealthDay News) -- Only one in four patients with sinonasal squamous cell carcinoma (SNSCC) is tested for human papillomavirus (HPV), according to a study published online Dec. 30 in Cancer.

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Peripheral Nervous System Events Not Common in Lupus

FRIDAY, Jan. 3, 2020 (HealthDay News) -- Peripheral nervous system (PNS) disease is a component of systemic lupus erythematosus (SLE) disease activity and has a significant negative impact on health-related quality of life, according to a study published in the January issue of Arthritis & Rheumatology.

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Cardiorespiratory Fitness Linked to Gray Matter Volume

FRIDAY, Jan. 3, 2020 (HealthDay News) -- Cardiorespiratory fitness (CRF) is positively associated with gray matter (GM) volume and total brain volume and with GM volume in specific brain areas, according to a study published in the January issue of the Mayo Clinic Proceedings.

Abstract/Full Text
Editorial

Guidance Developed for Providing Quality STD Care

THURSDAY, Jan. 2, 2020 (HealthDay News) -- In a report published in the Jan. 3 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report, recommendations are presented for providing quality sexually transmitted disease (STD) clinical services.

Abstract/Full Text

Diabetes Mellitus May Increase Risk for Developing Heart Failure

THURSDAY, Jan. 2, 2020 (HealthDay News) -- Patients with diabetes mellitus have an increased risk for heart failure, even in the absence of diastolic dysfunction, according to a study published in the January issue of the Mayo Clinic Proceedings.

Abstract/Full Text

Tau-PET Signal Predicts Atrophy in Early Alzheimer Disease

THURSDAY, Jan. 2, 2020 (HealthDay News) -- The global intensity of the tau-positron emission tomography (PET) signal predicts the rate of subsequent atrophy in patients at early symptomatic Alzheimer disease (AD) stages, according to a study published in the Jan. 1 issue of Science Translational Medicine.

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AI System Outperforms Radiologists in Breast Cancer Prediction

THURSDAY, Jan. 2, 2020 (HealthDay News) -- An artificial intelligence (AI) system can reduce false positives and false negatives in prediction of breast cancer and outperforms human readers, according to a study published online Jan. 1 in Nature.

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Patient Experiences Modestly Worse After Hospital Acquisition

THURSDAY, Jan. 2, 2020 (HealthDay News) -- Modestly worse patient experiences are seen following hospital acquisition by another hospital, according to a study published in the Jan. 2 issue of the New England Journal of Medicine.

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