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June 2008 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for June 2008. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Screening Tool May Aid Early Detection of Ovarian Cancer

THURSDAY, June 26 (HealthDay News) -- A composite tool consisting of a symptom index and the CA-125 blood test identified more than 80 percent of women with early-stage ovarian cancer and may be useful as part of a multi-step screening process for the disease, which is extremely difficult to detect in its early stages, according to study findings published online June 25 in Cancer.

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Cannabinoids Don't Alleviate Acute Nociceptive Pain

WEDNESDAY, June 25 (HealthDay News) -- Orally administered cannabis extract did not produce significant analgesic or anti-hyperalgesic effects in two well-established human pain models -- sunburn and intradermal capsaicin -- according to study findings published in the July issue of Anesthesiology.

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Haplotype Blocks in 8q24 Gene Desert Linked to Cancer

WEDNESDAY, June 25 (HealthDay News) -- Five specific loci within the 8q24 gene desert are associated with an increased risk of various cancers, according to research published in the July 2 issue of the Journal of the National Cancer Institute.

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Aldosterone Effect on Cardiac Hypertrophy Studied in Mice

TUESDAY, June 24 (HealthDay News) -- The hormone aldosterone can lead to cardiac hypertrophy in mice via the cytokine cardiotrophin-1 (CT-1), according to research published online June 19 in Endocrinology.

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Combined Therapy May Overcome Cancer Drug Resistance

MONDAY, June 23 (HealthDay News) -- A network of signaling is disrupted in cancer cells resistant to gefitinib, and combination treatment with gefitinib and another inhibitor may be able to overcome this resistance, researchers report in the June 20 issue of the Journal of Clinical Investigation.

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Article Examines Use of 'Key Opinion Leaders' in Drug Sales

FRIDAY, June 20 (HealthDay News) -- Influential doctors known as "key opinion leaders" are paid generous fees to influence their peers to prescribe a company's drugs and may in fact be considered salespeople by the industry, according to an article in the June 21 issue of BMJ.

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Editorial - Buckwell
Editorial - Fava

Surface Adhesion Molecule Promotes Immune Signaling

THURSDAY, June 19 (HealthDay News) -- Surface adhesion molecules can affect normal immune responses by stabilizing the interaction between antigen receptors and cellular structures, favoring the transmission of stimulatory signals, researchers report in the June 13 issue of Immunity.

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A New Pyridopyrimidine Derivative May Treat Diarrhea

THURSDAY, June 19 (HealthDay News) -- A newly identified pyridopyrimidine derivative that works against a toxin released by powerful strains of Escherichia coli may be effective against diarrhea, according to study findings published in the June 17 issue of the Proceedings of the National Academy of Sciences.

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Study of Cancer Stem Cells Marks Paradigm Shift

THURSDAY, June 12 (HealthDay News) -- The field of cancer stem cell research represents a paradigm shift in cancer diagnosis and treatment, according to a series of articles on the role of stem cells in various malignancies published in the June 10 issue of the Journal of Clinical Oncology.

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Peptide Level Points to Future Decompensated Heart Failure

TUESDAY, June 10 (HealthDay News) -- B-type natriuretic peptide (BNP) assessment six months after hospital discharge for decompensated heart failure identifies a long-term risk of future decompensation even in low-risk individuals with non-ischemic dilated cardiomyopathy, according to research published in the June 17 issue of the Journal of the American College of Cardiology.

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Low Birth Weight May Increase Autism Risk

TUESDAY, June 3 (HealthDay News) -- The prevalence of autism is higher among low birth weight or preterm children, particularly in females and in children with other developmental disabilities, according to research published in the June issue of Pediatrics.

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Study Sheds Light on Role of T3 in Male Rat Reproduction

MONDAY, June 2 (HealthDay News) -- Researchers have found expression of iodothyronine 5'-deiodinase (5'-D), an enzyme that creates the active form of triiodothyronine (T3) from thyroxine (T4), in several tissues in the male reproductive tract, according to study findings released online May 8 in advance of publication in Endocrinology. These findings may help shed light on the poorly understood role of thyroid hormones in regulating reproductive function in reproduction organs other than gonads.

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Compound Promising for Neurodegenerative Diseases

MONDAY, June 2 (HealthDay News) -- Scientists have discovered that a small polyphenol molecule that interferes with protein folding can be used to block the formation of toxic β-sheet-rich amyloid aggregates implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, according to an article published online May 30 in Nature Structural & Molecular Biology.

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Physician's Briefing
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