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March 2017 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for March 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

90 Percent of U.S. Physicians Satisfied With Career Choice

FRIDAY, March 31, 2017 (HealthDay News) -- Nine out of 10 American doctors are happy with their choice of profession, even though they have some challenges, according to an American Medical Association (AMA) survey of 1,200 doctors, residents, and medical students, conducted in February.

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Vertical Integration Insurance Products of Higher Quality

FRIDAY, March 31, 2017 (HealthDay News) -- Insurance products offered by hospitals and health systems, known as vertical integration, are generally of higher quality than other contracts, according to a study published in the March issue of Health Affairs.

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Microfluidic Culture Model of Female Reproductive Tract Built

FRIDAY, March 31, 2017 (HealthDay News) -- A microfluidic platform has been developed to model the human reproductive tract and menstrual cycle, according to a report published online March 28 in Nature Communications.

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C-Section, Maternal Health Impact Odds of Pediatric MS

FRIDAY, March 31, 2017 (HealthDay News) -- Maternal and perinatal factors that influence the risk of pediatric multiple sclerosis (MS) include cesarean delivery and maternal health during pregnancy, according to a study published in the April issue of Pediatrics.

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Extremely Low-Frequency Magnetic Fields Tied to ALS Death

THURSDAY, March 30, 2017 (HealthDay News) -- There seems to be a positive association for extremely low-frequency magnetic fields (ELF-MFs) exposure with amyotrophic lateral sclerosis (ALS) mortality in men, according to research published online March 29 in Occupational & Environmental Medicine.

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Study Explores Links Between Zika, GBS, Microcephaly in Brazil

WEDNESDAY, March 29, 2017 (HealthDay News) -- The causal links between Zika virus (ZIKV) infection, Guillain-Barré syndrome (GBS), and microcephaly need to be further clarified, according to a letter to the editor published online March 29 in the New England Journal of Medicine.

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Marathon Runners Show Signs of Short-Term Kidney Injury

WEDNESDAY, March 29, 2017 (HealthDay News) -- Marathon runners can develop acute kidney injury (AKI) and diagnostic indicators of tubular injury, according to a study published online March 28 in the American Journal of Kidney Disease.

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TV Ads for ACA Enrollment Linked to Decline in Uninsured Rates

TUESDAY, March 28, 2017 (HealthDay News) -- The volume of insurance advertisements during the first Affordable Care Act enrollment period correlated with change in uninsurance rates, with a higher volume of television advertisements linked to declines in uninsurance, according to a study published online March 15 in Health Affairs.

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BRCA Mutation Testing Shifts to Unaffected Women

TUESDAY, March 28, 2017 (HealthDay News) -- BRCA testing has shifted from being primarily used in cancer patients to being used in unaffected women, according to a study published online March 22 in the American Journal of Preventive Medicine.

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ACP Issues Challenge to Cut Task Burden and Put Patients First

TUESDAY, March 28, 2017 (HealthDay News) -- In a position paper published online March 28 in the Annals of Internal Medicine, recommendations are presented to address the impact of administrative tasks and reduce the administrative burden on clinicians.

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Paid Malpractice Claims Cut in Half From 1992 to 2014 in U.S.

MONDAY, March 27, 2017 (HealthDay News) -- From 1992 to 2014 there was a decrease in the rate of malpractice claims paid on behalf of physicians in the United States, but mean compensation amounts increased, according to a study published online March 27 in JAMA Internal Medicine.

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Genetic Hyperglycemia Raises Risk of Coronary Artery Disease

MONDAY, March 27, 2017 (HealthDay News) -- Genetic predisposition to hyperglycemia raises the odds of coronary artery disease (CAD), independent of type 2 diabetes and other CAD risk factors, according to research published online March 15 in Diabetes Care.

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Ultrasound IDs Ankle Pathology in Inflammatory Rheumatic Dz

FRIDAY, March 24, 2017 (HealthDay News) -- Patients with different types of inflammatory rheumatic diseases have distinct ankle pathological findings on ultrasonography, according to research published online March 13 in the International Journal of Rheumatic Diseases.

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30-Day Mortality Down During Joint Commission Survey Weeks

THURSDAY, March 23, 2017 (HealthDay News) -- Patients admitted to the hospital during The Joint Commission on-site inspections (surveys) have reduced mortality compared to that seen during non-survey weeks, according to research published online March 20 in JAMA Internal Medicine.

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Smartphone Device Analyzes Semen to Assess Male Fertility

THURSDAY, March 23, 2017 (HealthDay News) -- An automated smartphone-based semen analyzer can provide a semen quality evaluation with about 98 percent accuracy, according to research published in the March 22 issue of Science Translational Medicine.

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Black, Asian Medical Students Less Likely to Be AΩA Members

TUESDAY, March 21, 2017 (HealthDay News) -- Black and Asian medical students are less likely to be members of the Alpha Omega Alpha (AΩA) honor society than white students, according to a study published online March 6 in JAMA Internal Medicine.

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Phthalate, Paraben Levels Up in Children With Atopic Dermatitis

TUESDAY, March 21, 2017 (HealthDay News) -- Children aged 4 to 9 years with atopic dermatitis and with frequent use of emollients have increased urinary levels of low-molecular weight (LMW) phthalate metabolites and parabens, according to a study published online March 9 in Allergy.

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Serum Periostin IDs Comorbid Chronic Rhinosinusitis in Asthma

TUESDAY, March 21, 2017 (HealthDay News) -- For patients with asthma, serum periostin is useful for detecting chronic rhinosinusitis with nasal polyps, according to a study published online March 1 in the Annals of the American Thoracic Society.

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Magnesium Wasting Despite Diuretic Choice in Cervical CA Tx

MONDAY, March 20, 2017 (HealthDay News) -- For women with cervical cancer, administration of cisplatin concomitant with whole pelvic radiation is associated with magnesium wasting, according to a study published online March 9 in the Journal of Clinical Pharmacy and Therapeutics.

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CAR Activation Averts Cholesterol Gallstone Formation in Mice

MONDAY, March 20, 2017 (HealthDay News) -- Constitutive androstane receptor (CAR) activation decreases the biliary cholesterol concentration and can prevent formation of cholesterol gallstone disease (CGD), according to an experimental study published online March 7 in The American Journal of Pathology.

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Maternal Hyperglycemia Ups Offspring Cardiometabolic Risk

MONDAY, March 20, 2017 (HealthDay News) -- Maternal hyperglycemia during pregnancy is associated with increased risk of abnormal glucose tolerance, obesity, and increased blood pressure (BP) in offspring, independent of maternal obesity, according to a study published online March 9 in Diabetes Care.

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CDC: Suicide Rates Up in Less Urban Regions of United States

FRIDAY, March 17, 2017 (HealthDay News) -- Although the U.S. suicide rate has been rising gradually since 2000, suicides in less urban areas are outpacing those in more urban areas, according to research published in the March 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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High-Intensity Aerobic Exercise May Help Reverse Cellular Aging

THURSDAY, March 16, 2017 (HealthDay News) -- High-intensity exercise training can reverse some manifestations of aging in the body's protein function, according to a study published in the March issue of Cell Metabolism.

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Mixed Results for Stem Cell Treatments of AMD

THURSDAY, March 16, 2017 (HealthDay News) -- Stem cells may offer new hope for patients with age-related macular degeneration, but that promise can come with some risks, according to research published in the March 17 issue of the New England Journal of Medicine.

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Foreign Body Ingestion Can Result in Movement Disorder

THURSDAY, March 16, 2017 (HealthDay News) -- Ingestion of a foreign body can result in sudden onset of movement disorder in young children, according to a case report published online March 15 in Pediatrics.

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Esophageal Cancer Risk Rises Alongside Weight

WEDNESDAY, March 15, 2017 (HealthDay News) -- Overweight young adults may have a significantly increased risk of esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) if they become obese later in life, according to a study published online Feb. 14 in the British Journal of Cancer.

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Women Underrepresented Among Grand Rounds Speakers

WEDNESDAY, March 15, 2017 (HealthDay News) -- Women seem to be underrepresented among academic grand rounds (GR) speakers, according to a research letter published online March 6 in JAMA Internal Medicine.

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Cystic Fibrosis Patients in Canada Live Longer Than Those in U.S.

WEDNESDAY, March 15, 2017 (HealthDay News) -- Life expectancy has increased for patients with cystic fibrosis, but those in Canada live nearly 10 years longer than those in the United States, according to research published online March 14 in Annals of Internal Medicine.

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Blood Test Promising for ID of Early Depression, Schizophrenia

WEDNESDAY, March 15, 2017 (HealthDay News) -- The first objective, physiological marker for two major psychiatric disorders has been developed, according to a study published online March 13 in Experimental Physiology.

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Immune Responses to Ebola Vaccines Persist at One Year

WEDNESDAY, March 15, 2017 (HealthDay News) -- After heterologous primary and booster vaccination schedule of the adenovirus type 26 vector vaccine encoding Ebola virus glycoprotein (Ad26.ZEBOV) and the modified vaccinia virus Ankara vector vaccine, encoding glycoproteins from Ebola, Sudan, Marburg, and Tai Forest viruses nucleoprotein (MVA-BN-Filo) immunity persists for one year, according to a research letter published in the March 14 issue of the Journal of the American Medical Association.

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Support for Health Law Up to 48 Percent in February

TUESDAY, March 14, 2017 (HealthDay News) -- Support for the health law is increasing, with most Americans feeling that Medicaid should continue as it is today, according to a report published by Kaiser Health News.

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Risk of Heart Failure Up for Rheumatoid Arthritis Patients

TUESDAY, March 14, 2017 (HealthDay News) -- Patients with rheumatoid arthritis (RA) have increased risk of heart failure, according to a study published in the March 14 issue of the Journal of the American College of Cardiology.

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Visceral Fat Differentiates Crohn's From Intestinal Tuberculosis

TUESDAY, March 14, 2017 (HealthDay News) -- Visceral fat (VF) quantification can differentiate Crohn's disease (CD) and intestinal tuberculosis (ITB), according to a study published in the February issue of the Journal of Gastroenterology and Hepatology.

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Adverse CV Events Up Post Failure of Fertility Therapy

TUESDAY, March 14, 2017 (HealthDay News) -- Failed fertility therapy may increase risk of long-term adverse cardiovascular events, according to a study published online March 13 in CMAJ, the journal of the Canadian Medical Association.

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Higher Spending by Physicians Not Tied to Better Outcomes

MONDAY, March 13, 2017 (HealthDay News) -- Medicare patients treated by higher-spending physicians are just as likely to be readmitted or die within 30 days of being admitted to the hospital as patients treated by doctors who order fewer or less-expensive tests and treatments, according to a study published online March 13 in JAMA Internal Medicine.

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Mother-to-Child HIV Transmission Low, but More Progress Possible

MONDAY, March 13, 2017 (HealthDay News) -- A small proportion of HIV-infected women continue to transmit the virus to their neonates despite access to high-quality care, according to research published in the April issue of Obstetrics & Gynecology.

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Chorioretinal Lesions Secondary to Zika Virus Observed

MONDAY, March 13, 2017 (HealthDay News) -- Acute-onset, self-resolving, placoid or multifocal non-necrotizing chorioretinal lesions may be caused by Zika virus infection, according to a case report published online March 9 in JAMA Ophthalmology.

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Post-PCV13 Drop in Streptococcus pneumoniae Bacteremia

MONDAY, March 13, 2017 (HealthDay News) -- Introduction of seven-valent and 13-valent pneumococcal conjugate vaccine (PCV13) correlated with a reduction in Streptococcus pneumoniae bacteremia, according to a review published online March 10 in Pediatrics.

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Musculoskeletal Symptoms Predict Psoriatic Arthritis

MONDAY, March 13, 2017 (HealthDay News) -- For patients with psoriasis, nonspecific musculoskeletal symptoms, including joint pain, fatigue, and stiffness, predict the development of psoriatic arthritis (PsA), according to a study published in the March issue of Arthritis & Rheumatology.

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HBV Reactivation Seen With DAA Treatment of Chronic Hep C

MONDAY, March 13, 2017 (HealthDay News) -- For patients with chronic hepatitis C (CHC) treated with direct-acting antivirals (DAAs), hepatitis B virus (HBV) reactivation may occur in those with current HBV infection, according to a study published online Feb. 23 in the Journal of Gastroenterology and Hepatology.

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Risk of T2DM at Different BMIs Varies With Ethnicity

MONDAY, March 13, 2017 (HealthDay News) -- The risk of developing type 2 diabetes mellitus (T2DM) associated with body mass index (BMI) varies between ethnic groups, according to a study published online Feb. 17 in Diabetes, Obesity and Metabolism.

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Skin Prick, sIgE Have Moderate Agreement for Allergic Disease

MONDAY, March 13, 2017 (HealthDay News) -- For 10-year-old children, skin prick test (SPT) and specific immunoglobulin E (sIgE) have moderate agreement for allergic diseases, according to a study published online Feb. 24 in Allergy.

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Warm Autoimmune Hemolytic Anemia ID'd After Babesiosis

FRIDAY, March 10, 2017 (HealthDay News) -- Warm autoimmune hemolytic anemia (WAHA) develops in some patients after babesiosis, with asplenic patients at increased risk, according to a study published in the March 9 issue of the New England Journal of Medicine.

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Recent Outbreak of Yellow Fever in Brazil

THURSDAY, March 9, 2017 (HealthDay News) -- U.S. health officials are concerned about another potential mosquito-borne health threat to Americans -- yellow fever, according to a perspective piece published online March 8 in the New England Journal of Medicine.

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Cardiometabolic Risk Factors Not Always Seen With Obesity

THURSDAY, March 9, 2017 (HealthDay News) -- Almost 10 percent of obese people have no cardiometabolic risk factors (CRFs), according to research published March 9 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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EWG Report: Strawberries Have Most Pesticides

THURSDAY, March 9, 2017 (HealthDay News) -- Strawberries have the highest level of pesticide contamination in produce, while sweet corn and avocados have the lowest levels, according to an annual report from the Environmental Working Group.

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Rates of Hepatitis C Testing Too Low in Baby Boomers

WEDNESDAY, March 8, 2017 (HealthDay News) -- Despite recommendations, too few American baby boomers are tested for hepatitis C virus, according to a study published online March 8 in the American Journal of Preventive Medicine.

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Gluten Challenge Rarely Confirms Diagnosis of Gluten Sensitivity

WEDNESDAY, March 8, 2017 (HealthDay News) -- For patients diagnosed with nonceliac gluten sensitivity (NCGS), double-blind, placebo-controlled gluten challenge rarely confirms diagnosis, according to research published in the March issue of Clinical Gastroenterology and Hepatology.

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Routine Antenatal HIV Testing Cost-Effective

WEDNESDAY, March 8, 2017 (HealthDay News) -- Routine HIV testing is both cost-effective and cost-saving in antenatal settings, according to a review published online March 2 in the Journal of Clinical Nursing.

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Soy Linked to Prolonged Survival in Some Breast Cancer Patients

WEDNESDAY, March 8, 2017 (HealthDay News) -- Breast cancer survivors who consume more soy may have a lower risk of all-cause mortality over a 10-year period, according to a study published online March 6 in Cancer.

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CDC: Arthritis Limits the Activities of 24 Million U.S. Adults

WEDNESDAY, March 8, 2017 (HealthDay News) -- One in four adults in America report an arthritis diagnosis, with the number of individuals disabled by it up 20 percent since 2002, according to a report from the U.S. Centers for Disease Control and Prevention.

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Study Finds No Link Between Cytomegalovirus, Glioblastoma

WEDNESDAY, March 8, 2017 (HealthDay News) -- There's no link between cytomegalovirus (CMV) and glioblastoma or other high-grade gliomas, according to a study published recently in Clinical Cancer Research.

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Alterations in Soluble Mediators Predict Transition to SLE

WEDNESDAY, March 8, 2017 (HealthDay News) -- For unaffected relatives of systemic lupus erythematosus (SLE) patients, preclinical alterations in levels of soluble mediators may predict transition to disease, according to a study published in the March issue of Arthritis & Rheumatology.

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Five Million American Seniors Now Living With Alzheimer's

TUESDAY, March 7, 2017 (HealthDay News) -- Alzheimer's disease claims nearly twice as many American lives annually as it did just 15 years ago, according to the 2017 Alzheimer's Disease Facts and Figures report, published March 7 by the Alzheimer's Association.

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Republicans Introduce Affordable Care Act Replacement

TUESDAY, March 7, 2017 (HealthDay News) -- An initial Republican replacement for the Affordable Care Act was formally introduced in the House of Representatives on Monday.

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Cancer Screening Remains Below Healthy People 2020 Targets

TUESDAY, March 7, 2017 (HealthDay News) -- From 2000 to 2015 there were increases in colorectal cancer screening use, but not in breast or cervical cancer screening, according to a report published in the March 3 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Most Health Care Providers Can Offer Cost Estimate

MONDAY, March 6, 2017 (HealthDay News) -- Most provider organizations can offer a cost estimate, although few patients request one, according to a report published by Becker's Hospital CFO.

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Cost-Effectiveness Compared for Metastatic Melanoma Treatments

MONDAY, March 6, 2017 (HealthDay News) -- For patients with BRAF wild-type metastatic melanoma, first-line pembrolizumab (PEM) every three weeks followed by second-line ipilumumab (IPI), or first-line nivolumab (NIVO) followed by IPI, are the most cost-effective strategies, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

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Judgement Bias in Medical Device Recall Decisions

FRIDAY, March 3, 2017 (HealthDay News) -- The characteristics of the signal in user feedback of adverse events associated with medical devices and the situated context of decision makers correlate with judgement bias in reacting to these adverse events, according to research published online Jan. 29 in Production and Operations Management.

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Rate of Hearing Loss Projected to Almost Double in the U.S. by 2060

FRIDAY, March 3, 2017 (HealthDay News) -- Among American adults 20 and older, hearing loss is expected to increase from 44 million in 2020 (15 percent of adults) to 73.5 million by 2060 (23 percent of adults), according to a research letter published online March 2 in JAMA Otolaryngology-Head & Neck Surgery.

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Insecticides Linked to Behavioral Issues in Children

FRIDAY, March 3, 2017 (HealthDay News) -- Children exposed to a widely-used group of insecticides (pyrethroids) may be at increased risk for behavioral problems, according to a study published online March 1 in Occupational & Environmental Medicine.

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Skin Diseases Responsible for Significant Economic Burden

FRIDAY, March 3, 2017 (HealthDay News) -- Skin diseases have a major impact on Americans and the U.S. economy, according to a report published online March 1 in the Journal of the American Academy of Dermatology.

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CDC: Children Getting Ill From Ingesting Gel Hand Sanitizer

FRIDAY, March 3, 2017 (HealthDay News) -- A rising number of children are becoming ill from ingesting gel hand sanitizer, according to research published in the March 3 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Hospital Floors May Be Breeding Ground for Superbugs

FRIDAY, March 3, 2017 (HealthDay News) -- Hospital room floors may be more of an infection threat than many hospital staffers realize, according to a study published in the March 1 issue of the American Journal of Infection Control.

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CDC: Odds of Birth Defects Up 20-Fold in Mothers With Zika

FRIDAY, March 3, 2017 (HealthDay News) -- Pregnant women infected with the Zika virus are 20 times more likely to have an infant born with certain birth defects as mothers who gave birth before the Zika epidemic began, according to research published in the March 3 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Overall, 8.8 Percent of U.S. Population Uninsured in 2016

THURSDAY, March 2, 2017 (HealthDay News) -- Overall, 8.8 percent of individuals of all ages were uninsured in the first nine months of 2016, which marked a nonsignificant reduction from 2015, according to a Feb. 14 report from the National Center for Health Statistics.

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Gene Therapy Described in a Patient With Sickle Cell Disease

THURSDAY, March 2, 2017 (HealthDay News) -- In a brief report published in the March 2 issue of the New England Journal of Medicine, researchers detail their early success using gene therapy to treat, or even potentially cure, sickle cell disease.

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Colorectal Cancer Rates, Mortality Down in Americans Aged ≥50

WEDNESDAY, March 1, 2017 (HealthDay News) -- Colorectal cancer (CRC) rates among those aged 50 and older have fallen 32 percent since 2000, while deaths from the disease fell by 34 percent, according to a report published online March 1 in CA: A Cancer Journal for Clinicians.

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Colorectal Cancer Facts & Figures 2017-2019

Review Supports Link Between Adiposity, Risk of Some Cancers

WEDNESDAY, March 1, 2017 (HealthDay News) -- Additional weight appears to particularly influence the risk of cancers related to the digestive organs or those driven by hormonal abnormalities, according to a review published online Feb. 28 in The BMJ.

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Exposure to Neuraminidase Inhibitors in Utero Not Harmful

WEDNESDAY, March 1, 2017 (HealthDay News) -- Exposure to neuraminidase inhibitors during pregnancy is not associated with adverse neonatal outcomes or congenital malformations, according to a study published online Feb. 28 in The BMJ.

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Physician's Briefing
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