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September 2008 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2008. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

News Media Under-Report Drug Company Funding of Research

TUESDAY, Sept. 30 (HealthDay News) -- Reports on medication research published in general news media often fail to disclose that the research received pharmaceutical company funding and frequently refer to drugs by brand name rather than using the generic name, according to an article published in the Oct. 1 issue of the Journal of the American Medical Association.

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Gene Variant Linked to Lower Colorectal Cancer Risk

TUESDAY, Sept. 30 (HealthDay News) -- A variation of the adiponectin (ADIPOQ) gene is associated with a significantly decreased risk of colorectal cancer, according to a report published in the Oct. 1 issue of the Journal of the American Medical Association.

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Reduced Dosing Schedule Acceptable for Anthrax Vaccine

TUESDAY, Sept. 30 (HealthDay News) -- A three-dose intramuscular (3-IM) regimen of anthrax vaccine adsorbed (AVA) achieves a similar serological response compared to a four-dose intramuscular (4-IM) or subcutaneous (4-SQ) regimen, and fewer injection site adverse effects are seen with IM administration, according to a report in the Oct. 1 issue of the Journal of the American Medical Association .

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Statins Don't Raise Risk of Amyotrophic Lateral Sclerosis

TUESDAY, Sept. 30 (HealthDay News) -- Using statins does not raise the risk of developing amyotrophic lateral sclerosis (ALS), according to research conducted by the U.S. Food and Drug Administration and published online Sept. 29 in Pharmacoepidemiology and Drug Safety.

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Periodic Fasting May Decrease Cardiac Risk

MONDAY, Sept. 29 (HealthDay News) -- Both the proscription of tobacco products and periodic fasting may lower the risk of coronary artery disease, according to the results of a study published in the Oct. 1 issue of the American Journal of Cardiology.

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Bisphosphonate Infusion Linked to Ocular Complication

WEDNESDAY, Sept. 24 (HealthDay News) -- Physicians should be aware that bisphosphonate infusions can result in a serious but rare complication: orbital inflammatory disease, according to a case study published in the Sept. 25 issue of the New England Journal of Medicine.

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HIV Prevalence High Among Injection Drug Users

WEDNESDAY, Sept. 24 (HealthDay News) -- Although the data is limited, injection drug use occurs in most countries and the prevalence of HIV among injection drug users is over 40 percent in some cases, according to a report published online Sept. 24 in The Lancet.

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Racial Discrepancies Exist for Asymptomatic Colon Polyps

TUESDAY, Sept. 23 (HealthDay News) -- Black patients undergoing colonoscopy reveal a higher prevalence of polyps compared to white individuals, according to data reported in the Sept. 24 issue of the Journal of the American Medical Association.

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Nasal Insulin Doesn't Prevent Type 1 Diabetes in At-Risk Kids

TUESDAY, Sept. 23 (HealthDay News) -- Prophylactic administration of nasal insulin soon after birth does not prevent children with HLA genotypes and autoantibodies from developing type 1 diabetes, nor does it delay onset of the disease, according to research published online Sept. 23 in The Lancet.

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Needle Core Biopsies of Renal Masses Are Accurate, Safe

MONDAY, Sept. 22 (HealthDay News) -- Needle core biopsies are safe and correctly identify benign versus malignant renal tumors in small, asymptomatic renal lesions, according to a report in the October issue of the Journal of Urology.

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Mutation Linked to Leukemia in Down Syndrome

MONDAY, Sept. 22 (HealthDay News) -- About a fifth of Down syndrome patients with acute lymphoblastic leukemia have a mutation in the Janus kinase 2 (JAK2) protein, according to a report published online Sept. 20 in The Lancet.

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Hepatitis B Screening Recommendations Expanded

FRIDAY, Sept. 19 (HealthDay News) -- New recommendations have been issued regarding screening for chronic hepatitis B, according to a report released by the U.S. Centers for Disease Control and Prevention published in the Sept. 19 issue of the Morbidity and Mortality Weekly Report.

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Antibiotic Resistance Has Become a Global Pandemic

FRIDAY, Sept. 19 (HealthDay News) -- A concerted international and national response, behavior change by consumers and providers, and the development of antibacterial agents are all urgently needed to tackle the global problem of rapidly increasing antibiotic resistance, according to an article published online Sept. 18 in BMJ.

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Vaccine Against H. pylori Shows Promise in Phase I Study

THURSDAY, Sept. 18 (HealthDay News) -- An intramuscular vaccine against Helicobacter pylori offers promising immunogenicity and appears safe, according to research published in the September issue of Gastroenterology.

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Early Viral Loads Predict Response to HBV Treatment

THURSDAY, Sept. 18 (HealthDay News) -- Patients infected with hepatitis B virus (HBV) treated with peginterferon and lamivudine are more likely to have a sustained virologic response if their HBV DNA levels are below 10,000 copies/mL after eight weeks of treatment, according to research published in the September issue of Clinical Gastroenterology and Hepatology.

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Screening May Point to Lung Cancer Before Symptoms Arise

WEDNESDAY, Sept. 17 (HealthDay News) -- Diagnosing lung cancer before symptoms become evident may be possible by screening for autoantibodies to particular antigens, according to research published online Sept. 15 in the Journal of Clinical Oncology.

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Maternal Vaccine Reduces Influenza in Infants

WEDNESDAY, Sept. 17 (HealthDay News) -- The use of influenza vaccine in pregnant women can decrease the risk of influenza in their infants up to six months of age and offer protection against febrile respiratory illness in both mothers and infants, according to research published online Sept. 17 in the New England Journal of Medicine.

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Bisphenol A Concentrations Linked to Chronic Diseases

TUESDAY, Sept. 16 (HealthDay News) -- People with higher urinary levels of Bisphenol A (BPA) -- a chemical compound widely used in epoxy resins lining food and beverage containers -- may have an increased risk of cardiovascular disease, type 2 diabetes and liver-enzyme abnormalities, researchers report in the Sept. 17 issue of the Journal of the American Medical Association.

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DNA Vaccine Developed for Drug-Resistant Breast Cancer

TUESDAY, Sept. 16 (HealthDay News) -- Drug-resistant breast cancer, especially due to overexpression of Her-2/neu, can now be safely and effectively controlled with targeted DNA vaccines, according to research published in the Sept. 15 issue of Cancer Research.

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Lab Test Ratio Predicts Risk Among Coronary Patients

MONDAY, Sept. 15 (HealthDay News) -- The neutrophil/lymphocyte ratio (NLR) is a comparatively inexpensive marker of inflammation that identifies high-risk patients and may allow for risk stratification of patients with acute coronary syndromes, according to a report in the Sept. 15 issue of the American Journal of Cardiology.

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Models for BRCA1/2 Mutation Prediction Miss Mark in Asians

FRIDAY, Sept. 12 (HealthDay News) -- Two common prediction models for BRCA1/2 mutations -- BRCAPRO and Myriad II -- underestimated the number of mutation carriers in a sample of Asian Americans, compared to their accurate prediction of mutation carriers in whites, according to research published online Sept. 8 in the Journal of Clinical Oncology.

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