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September 2016 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Platelet Transfusion Has Minimal Effect for Reversing Ticagrelor

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Autologous platelet transfusion 24 or 48 hours after ticagrelor-mediated platelet inhibition has minimal effect, while a small reversing effect is seen for transfusion after clopidogrel, according to a study published online Sept. 22 in the Journal of Thrombosis and Haemostasis.

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CDC: Too Many Health Care Workers Not Getting Flu Vaccine

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Roughly one in every five American health care workers do not receive the annual influenza vaccination, and in some facilities that number exceeds half, according to research published in the Sept. 30 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Retrieved Lymph Node Number Affects Prognosis in Gastric CA

FRIDAY, Sept. 30, 2016 (HealthDay News) -- In patients with pathological stage (pStage) II or III gastric cancer, the number of retrieved lymph nodes (RLNs) is an independent poor prognostic factor, according to a study published in the September issue of the Journal of Gastroenterology and Hepatology.

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Meditation Recommended for Helping Attendings 'Attend'

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Meditation can allow attending physicians to be "in attendance" in order to heal and maintain personal well-being, according to an article published by the American Medical Association.

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More Evidence HPV Vaccine Protects Against Cervical Cancer

THURSDAY, Sept. 29, 2016 (HealthDay News) -- The vaccine against human papillomavirus (HPV) infection appears even more effective than previously believed, according to a report published online Sept. 29 in JAMA Oncology.

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Physical Activity Does Not Appear to Lower MS Risk in Women

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Regular physical activity won't lower the risk of multiple sclerosis (MS) in women, according to research published online Sept. 28 in Neurology.

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Radiation Effect on Epigenetic Modifiers May Up Metabolic Risk

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Total body irradiation alters intracellular signaling and epigenetic pathways regulating cell proliferation and differentiation of skeletal muscle and adipose progenitor cells, according to an experimental study published online Sept. 20 in Diabetes.

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Findings May Help Optimize Tissue Expansion Procedures

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Researchers have developed a method to measure the limit to which human skin can be stretched, which could lead to a new means to grow skin, according to a study published in the Oct. 1 issue of Acta Biomaterialia.

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Many Doctors Reluctant to Reveal Mental Health Issues

WEDNESDAY, Sept. 28, 2016 (HealthDay News) -- Wary of the stigma of a mental health diagnosis and its toll on their careers, physicians often avoid getting help for depression and other mental illnesses, according to a report published online Sept. 15 in General Hospital Psychiatry.

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IgE to Ana o 3 Can Identify Cashew Allergy in Children

WEDNESDAY, Sept. 28, 2016 (HealthDay News) -- Specific immunoglobulin E (IgE) to the 2 S albumin from cashew, Ana o 3, can discriminate between cashew nut allergic and tolerant children, according to a study published online Sept. 19 in Allergy.

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Manuka Honey Prevents Early Biofilm Formation

TUESDAY, Sept. 27, 2016 (HealthDay News) -- Diluted Manuka honey can prevent early biofilm formation, according to a study published online Sept. 26 in the Journal of Clinical Pathology.

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Number of COPD Cases Expected to Increase Through 2030

TUESDAY, Sept. 27, 2016 (HealthDay News) -- The number of chronic obstructive pulmonary disease (COPD) cases is expected to increase through 2030, with the greatest increase anticipated for those aged 75 years and older, according to research published online Sept. 4 in the American Journal of Respiratory and Critical Care Medicine.

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Gliptin Treatment Tied to Higher Risk of Acute Pancreatitis

TUESDAY, Sept. 27, 2016 (HealthDay News) -- Gliptin treatment is associated with increased acute pancreatitis risk, according to research published online Sept. 22 in Diabetes Care.

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Little to No Benefit Found for Colonoscopy After Age 75

TUESDAY, Sept. 27, 2016 (HealthDay News) -- A colonoscopy may not provide much colorectal cancer (CRC) prevention benefit after the age of 75, according to a study published online Sept. 27 in the Annals of Internal Medicine.

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Increased HIV Testing Among Men Who Have Sex With Men

MONDAY, Sept. 26, 2016 (HealthDay News) -- There seems to be a trend toward increased HIV testing and earlier HIV diagnosis among men who have sex with men (MSM), according to a report published in the Sept. 23 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Cancer Patients Have Unrealistic Hopes Entering Clinical Trials

MONDAY, Sept. 26, 2016 (HealthDay News) -- Many cancer patients hold unrealistic hopes when they decide to join early-stage clinical trials of experimental treatments, according to research published online Sept. 26 in Cancer.

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Drug-Resistant Bacteria Live in America's Water Systems

FRIDAY, Sept. 23, 2016 (HealthDay News) -- The thousands of miles of aging, corroding pipes that bring water to Americans each day may be home to drug-resistant bacteria, according to a report published online Sept. 12 in the Journal of Public Health Policy.

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uPAR Elevated in Bronchial Tissue of Asthma Patients

FRIDAY, Sept. 23, 2016 (HealthDay News) -- Urokinase plasminogen activator receptor (uPAR) is elevated in patients with asthma, with high uPAR levels linked to severe, non-atopic disease, according to a study published online Sept. 14 in Allergy.

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TP53, MDM2 Alterations Linked to Cisplatin Resistance in GCT

FRIDAY, Sept. 23, 2016 (HealthDay News) -- In germ cell tumors (GCTs), TP53 and MDM2 alterations correlate with cisplatin resistance and are associated with inferior outcome, according to a study published online Sept. 19 in the Journal of Clinical Oncology.

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Exposure to Phthalates, BPA May Impact Total 25(OH)D in Adults

FRIDAY, Sept. 23, 2016 (HealthDay News) -- Exposure to phthalates and bisphenol A (BPA) may impact circulating levels of total 25-hydroxyvitamin D (25[OH]D), according to a study published online Sept. 20 in the Journal of Clinical Endocrinology & Metabolism.

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Dementia, Mortality Risk Up for GBA Carriers With Parkinson's

THURSDAY, Sept. 22, 2016 (HealthDay News) -- Parkinson's disease (PD) patients with glucocerebrosidase gene (GBA) mutations have increased risk for dementia and death, according to a study published online Sept. 15 in the Annals of Neurology.

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Animal Study Finds DNA-Based Vaccine Effective Against Zika

THURSDAY, Sept. 22, 2016 (HealthDay News) -- An experimental DNA-based vaccine for Zika virus has proceeded to human safety trials, according to findings published online Sept. 22 in Science.

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CDC: Falls Leading Cause of Injury, Death in U.S. Seniors

THURSDAY, Sept. 22, 2016 (HealthDay News) -- Falls are the leading cause of injury and death among older people in the United States, according to research published in the Sept. 23 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Laquinimod Appears Effective Against Multiple Sclerosis

THURSDAY, Sept. 22, 2016 (HealthDay News) -- An experimental drug, laquinimod, appears to prevent or slow the progression of multiple sclerosis (MS) in mice, according to a study published online Sept. 21 in Neurology: Neuroimmunology & Neuroinflammation.

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KAF156 Active for Adults With Vivax, Falciparum Malaria

THURSDAY, Sept. 22, 2016 (HealthDay News) -- For adults with acute Plasmodium vivax or P. falciparum, KAF156 shows antimalarial activity, according to a study published in the Sept. 22 issue of the New England Journal of Medicine.

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Decline in eGFR Mainly Linear in Type 1 Diabetes

THURSDAY, Sept. 22, 2016 (HealthDay News) -- For patients with type 1 diabetes, the decline of estimated glomerular filtration rate (eGFR) is mainly linear, according to a study published online Sept. 19 in Diabetes Care.

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Changes in Blood Microbiota in Obese With Liver Fibrosis

THURSDAY, Sept. 22, 2016 (HealthDay News) -- In obese patients, changes in blood microbiota are associated with liver fibrosis, according to a study published online Sept. 17 in Hepatology.

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Findings to Help Radiologists ID Zika Virus Infection at Imaging

THURSDAY, Sept. 22, 2016 (HealthDay News) -- Congenital brain abnormalities are similar for confirmed and presumed Zika infections, according to a study published in the October issue of Radiology.

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FTO Gene Does Not Inhibit Weight Loss Success

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Patients with the FTO gene respond to weight-loss strategies as well as those without the gene, according to research published online Sept. 20 in The BMJ.

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Smoking Appears to Have Broad, Long-Lasting Impact on DNA

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Smoking cigarettes can leave a lasting imprint on human DNA, altering more than 7,000 genes in ways that may contribute to the development of smoking-related diseases, according to research published online Sept. 20 in Circulation: Cardiovascular Genetics.

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AACR: More Cancer Patients Benefiting From Immunotherapy

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- More Americans are benefiting from immunotherapy, according to the sixth annual American Association for Cancer Research (AACR) Cancer Progress Report.

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NIH: More Must Be Done to Fight Antimicrobial Resistance

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Antimicrobial resistance (AMR) remains a major public health threat, and only a multipronged attack can address the problem, according to a report published in the Sept. 20 issue of the Journal of the American Medical Association.

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Obese Children, Teens Exhibit Different Gut Flora Composition

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Obese children and adolescents have different gut flora composition than their normal-weight peers, according to a study published online Sept. 20 in the Journal of Clinical Endocrinology & Metabolism.

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Fatty Acid Binding Protein 4 Tied to Preeclampsia Risk in T1DM

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- For women with type 1 diabetes, elevated fatty acid binding protein 4 (FABP4) in early pregnancy and in the second trimester is associated with subsequent preeclampsia, according to a study published online Sept. 14 in Diabetes Care.

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Research Reveals 2 Genetic Loci Linked to Acute Kidney Injury

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Four single-nucleotide polymorphisms at two loci that are associated with acute kidney injury have been identified, according to a study published online Aug. 30 in the American Journal of Respiratory and Critical Care Medicine.

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New Mosquito-Borne Virus Detected in 8-Year-Old in Haiti

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Another mosquito-borne virus may be starting to circulate in the Caribbean, according to findings published online recently in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

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Hospitals Increasingly Employing Doctors, Effects on Care Uncertain

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Hospitals are increasingly switching to an employment relationship with physicians, but switching has had no impact on primary composite quality metrics, according to a study published online Sept. 20 in the Annals of Internal Medicine.

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No Link Found Between Vasectomy, Prostate Cancer Risk

TUESDAY, Sept. 20, 2016 (HealthDay News) -- There is no connection between vasectomy and overall risk of prostate cancer or prostate cancer mortality, according to a study published online Sept. 19 in the Journal of Clinical Oncology.

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Diabetes Risk Higher in Canada's First Nations People

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Diabetes is more widespread among descendants of Canada's First Nations people than among the general population, according to a study published online Sept. 19 in CMAJ, the journal of the Canadian Medical Association.

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Drop in Use of Digital Rectal Examination, PSA Testing

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Following U.S. Preventive Services Task Force (USPSTF) recommendations against routine prostate-specific antigen (PSA) screening, there has been a decrease in utilization of digital rectal examination and PSA testing, according to a study published in the October issue of The Journal of Urology.

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BNPratio Predicts Mortality in Degenerative Mitral Regurgitation

TUESDAY, Sept. 20, 2016 (HealthDay News) -- The ratio of B-type natriuretic peptide (BNP) to upper limit of normal for age, sex, and assay (BNPratio) predicts long-term mortality for patients with mitral regurgitation (MR) who undergo medical management, according to a study published in the Sept. 20 issue of the Journal of the American College of Cardiology.

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CSF Neurofilament Light Proteins Increased Post-Concussion

MONDAY, Sept. 19, 2016 (HealthDay News) -- Professional ice hockey players with post-concussion syndrome (PCS) have increased cerebrospinal fluid neurofilament light proteins and reduced amyloid β, according to a study published online Sept. 19 in JAMA Neurology.

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IL-32 Has Inflammatory Properties in Human Obesity

MONDAY, Sept. 19, 2016 (HealthDay News) -- Interleukin (IL)-32 has inflammatory and remodeling properties in human obesity, according to a study published online Sept. 14 in Diabetes.

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Average Premiums for Health Care Coverage Stable in 2016

MONDAY, Sept. 19, 2016 (HealthDay News) -- The average annual premiums for single and family coverage remained stable in 2016, according to a study published online Sept. 14 in Health Affairs.

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Recent Decline in Cancer Mortality for Children, Teens

FRIDAY, Sept. 16, 2016 (HealthDay News) -- There was a decrease in cancer mortality from 1999 to 2014 for children and adolescents aged 1 to 19 years, according to a September data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Medical Marijuana Laws Linked to Reduced Opioid Use, Abuse

FRIDAY, Sept. 16, 2016 (HealthDay News) -- A new study of drivers who died in auto accidents suggests people in states with medical marijuana laws may be using fewer opioids, according to a study published online Sept. 15 in the American Journal of Public Health.

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Study Supports Minimal Residual Disease As End Point in Myeloma

FRIDAY, Sept. 16, 2016 (HealthDay News) -- For patients with newly diagnosed multiple myeloma (MM), minimal residual disease (MRD)-negative status is associated with improved survival, according to a meta-analysis published online Sept. 15 in JAMA Oncology.

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Zika Virus Present in Conjunctival Fluid

FRIDAY, Sept. 16, 2016 (HealthDay News) -- The Zika virus can be detected in conjunctival fluid, according to a research letter published online Sept. 15 in JAMA Ophthalmology.

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Immunosuppressant-Free Retinal Stem Cell Transplant Feasible

THURSDAY, Sept. 15, 2016 (HealthDay News) -- Scientists report they have successfully transplanted reprogrammed monkey stem cells into the eyes of other monkeys without the need for immunosuppressants. These results were published online Sept. 15 in Stem Cell Reports.

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Outlook Good for Localized Prostate CA, Despite Tx Chosen

THURSDAY, Sept. 15, 2016 (HealthDay News) -- Mortality rates from localized prostate cancer are roughly the same over several years regardless of choosing watchful waiting or undergoing radiation or prostatectomy, according to research published online Sept. 14 in the New England Journal of Medicine.

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Daily Alcohol Intake Linked to Enlarged Left Atrium, A-Fib

THURSDAY, Sept. 15, 2016 (HealthDay News) -- Long-term drinking of even moderate amounts of alcohol may enlarge the left atrium and thereby contribute to atrial fibrillation (AF), according to a study published online Sept. 14 in the Journal of the American Heart Association.

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Lower Citrulline Values With Metformin Treatment in T2DM

THURSDAY, Sept. 15, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), metformin treatment is associated with lower citrulline values, according to a study published online Sept. 12 in Diabetes.

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Recommendations Developed for Cost-Effectiveness Analyses

THURSDAY, Sept. 15, 2016 (HealthDay News) -- A new set of recommendations has been developed for conduct and reporting of cost-effectiveness analyses, according to a report published in the Sept. 13 issue of the Journal of the American Medical Association.

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Value-Driven Outcomes Tool Can Cut Health Care Costs

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- A multifaceted value-driven outcomes tool that identifies variability in costs and outcomes can reduce health care costs, according to a study published in the Sept. 13 issue of the Journal of the American Medical Association.

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Infective Endocarditis Incidence 1.1 Percent After TAVR

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- For patients undergoing transcatheter aortic valve replacement (TAVR) the incidence of infective endocarditis is 1.1 percent per person-year, according to a study published in the Sept. 13 issue the Journal of the American Medical Association.

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Newborn Gut Microbiome May Predict Later Allergy, Asthma

TUESDAY, Sept. 13, 2016 (HealthDay News) -- Compositionally distinct human neonatal gut microbiota appear differentially related to risk of childhood atopy and asthma, according to research published online Sept. 12 in Nature Medicine.

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Advanced Glycation End Products Tied to Renal Function Loss

TUESDAY, Sept. 13, 2016 (HealthDay News) -- For American-Indians with type 2 diabetes, advanced glycation end products (AGEs) are associated with renal function loss (RFL), according to a study published online Sept. 8 in Diabetes.

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Positive FCal Not Likely to Indicate IBD in Peds Primary Care

TUESDAY, Sept. 13, 2016 (HealthDay News) -- For children with gastrointestinal symptoms seen in primary care, a positive fecal calprotectin (FCal) result is not likely to indicate inflammatory bowel disease (IBD), according to a study published in the September/October issue of Annals of Family Medicine.

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U-Shaped Link for Fish Consumption, Mortality

TUESDAY, Sept. 13, 2016 (HealthDay News) -- There is a U-shaped correlation between fish consumption and all-cause mortality, according to a study published online Sept. 7 in the Journal of Internal Medicine.

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Metabolic Syndrome and Obesity Up Risk of Mortality in CRC

TUESDAY, Sept. 13, 2016 (HealthDay News) -- For patients with early-stage colorectal cancer (CRC), the presence of metabolic syndrome (MetSyn) and obesity is associated with increased risk of mortality, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

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Sleep Apnea Diagnoses Up Among Outpatients From 1993 to 2010

MONDAY, Sept. 12, 2016 (HealthDay News) -- From 1993 to 2010 there was an increase in the diagnosis of sleep apnea in U.S. ambulatory practice visits, according to a study published online Sept. 1 in the Annals of the American Thoracic Society.

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Long-Term Exposure to Air Pollution Ups Insulin Resistance

MONDAY, Sept. 12, 2016 (HealthDay News) -- Long-term exposure to air pollution is associated with insulin resistance (IR) among the general population, according to a study published online Sept. 7 in Diabetes.

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Reports of Fatal Anaphylaxis With IV Iron Products

MONDAY, Sept. 12, 2016 (HealthDay News) -- Fatal anaphylaxis cases have been reported with administration of intravenous (IV) iron products, according to a letter to the editor published online Aug. 29 in the American Journal of Hematology.

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High Glycemic Index Diet Raises Hepatic Fat, Glycogen Stores

FRIDAY, Sept. 9, 2016 (HealthDay News) -- A one-week high glycemic index (HGI) diet increases hepatic fat and glycogen stores in healthy adults compared with a low glycemic index (LGI) diet, according to a study published online Sept. 4 in Diabetes, Obesity and Metabolism.

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Experimental Drug Shows Promise in Melanoma

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Pevonedistat, a specific inhibitor of the NEDD8 activating enzyme, inhibits the activity of cullin E3 ligases, inhibiting cancer cells in vitro, according to a study published in the August issue of EBioMedicine.

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CDC: COPD-Related Mortality Mostly Down in the United States

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Fewer Americans are dying from chronic obstructive pulmonary disease (COPD), but not black women and the middle-aged, according to a September data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Remission Up With T Cell Therapy for Non-Hodgkin's Lymphoma

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Immunotherapy with CD19 chimeric antigen receptor (CAR)-modified T cells in a defined CD4+/CD8+ ratio can lead to improved disease response and overall and progression-free survival, according to a study published in the Sept. 7 issue of Science Translational Medicine.

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Treating Leukemia With Cord-Blood Transplant Looks Promising

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Umbilical cord blood may work as well as current alternatives for adults and children with leukemia -- or even better in some cases, according to a study published in the Sept. 8 issue of the New England Journal of Medicine.

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Obesity May Up Survival in Metastatic Renal Cell Carcinoma

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Obesity may increase survival for patients with metastatic renal cell carcinoma (RCC), according to a study published online Sept. 6 in the Journal of Clinical Oncology.

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PSA Failure Predicts Death in Men With No, Minimal Comorbidity

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Prostate-specific antigen (PSA) failure is associated with increased risk of all-cause mortality for men with intermediate- or high-risk prostate cancer with no or minimal comorbidity, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

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Oral Contraceptives May Be Cause of Drop in Ovarian CA Mortality

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Ovarian cancer mortality is down dramatically in many parts of the world, and the use of oral contraceptives (OCs) may be a main reason why, according to a study published online Sept. 5 in the Annals of Oncology.

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A-Fib Contributes to Wide Range of Other Health Conditions

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Atrial fibrillation is associated with a wider range of conditions than previously believed, according to a review and meta-analysis published online Sept. 6 in The BMJ.

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Free Thyroxine Hormone Levels Linked to Sudden Cardiac Death

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Higher levels of free thyroxine (FT4) may indicate a greater risk of sudden cardiac death, even if those levels aren't abnormally high, according to a study published in the Sept. 6 issue of Circulation.

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FGF21, Dietary Intake Interaction Impacts Adiposity

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Fibroblast growth factor 21 (FGF21) genotypes may interact with dietary macronutrient intake to affect central adiposity and body fat composition, according to a study published online Aug. 31 in Diabetes Care.

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AAFP Downgrades USPSTF CRC Screening Recommendation

TUESDAY, Sept. 6, 2016 (HealthDay News) -- The American Academy of Family Physicians (AAFP) has graded the recommendation for colorectal cancer screening as a B recommendation, in contrast to the U.S. Preventive Services Task Force (USPSTF) grade A recommendation.

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More Diabetes-Associated, Non-Associated Autoantibodies in T1D

TUESDAY, Sept. 6, 2016 (HealthDay News) -- Patients with type 1 diabetes have more diabetes-associated autoantibodies (DAAs) and non-DAAs than patients with type 2 diabetes, according to a study published online Aug. 29 in Diabetes Care.

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Reflectance Confocal Microscopy Best IDs Melanoma on Head, Neck

FRIDAY, Sept. 2, 2016 (HealthDay News) -- Reflectance confocal microscopy (RCM) best identifies skin cancer lesions on the head and neck, and RCM morphologic patterns differ for distinct melanomas, according to two studies published online Aug. 31 in JAMA Dermatology.

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Infective Endocarditis From Injection Drug Use Increasing

FRIDAY, Sept. 2, 2016 (HealthDay News) -- The number of Americans hospitalized with infective endocarditis (IE) related to injecting opioids and heroin is on the rise, according to a study published in the Summer issue of Open Forum Infectious Diseases.

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Rise in Endogenous Klebsiella pneumoniae Endophthalmitis

FRIDAY, Sept. 2, 2016 (HealthDay News) -- Increasing trends of endogenous Klebsiella pneumoniae endophthalmitis (EKPE) have been reported in Australia, according to research published online Aug. 26 in Clinical & Experimental Ophthalmology.

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Novel Findings Support Original Categorization of HER2

THURSDAY, Sept. 1, 2016 (HealthDay News) -- The original classifications of human epidermal growth factor receptor 2 (HER2) categorization by fluorescent in situ hybridization (FISH) have been supported by recent data, according to a report published online Aug. 29 in the Journal of Clinical Oncology.

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Dapagliflozin Improves Insulin Sensitivity in Type 2 Diabetes

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Dapagliflozin improves insulin sensitivity and increases lipid oxidation and plasma ketone concentration in patients with type 2 diabetes mellitus (T2DM), according to a study published online Aug. 25 in Diabetes Care.

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Folic Acid-Fortified Food Tied to Drop in Congenital Heart Defects

THURSDAY, Sept. 1, 2016 (HealthDay News) -- The introduction of folic acid-fortified foods in Canada was associated with a decrease in infants being born with congenital heart defects (CHDs), according to a study published in the Aug. 30 issue of Circulation.

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Comorbidity Factors Identified for Exacerbation-Prone Asthma

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Factors that are associated with exacerbation-prone asthma (EPA) have been identified, with blood eosinophils, body mass index, and bronchodilator responsiveness associated with exacerbation frequency, according to a study published online Aug. 24 in the American Journal of Respiratory and Critical Care Medicine.

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Δ9-Tetrahydrocannabivarin Beneficial in Type 2 Diabetes

THURSDAY, Sept. 1, 2016 (HealthDay News) -- For patients with non-insulin-treated type 2 diabetes, Δ9-tetrahydrocannabivarin (THCV) reduces fasting plasma glucose, and improves pancreatic β-cell function, adiponectin, and apolipoprotein A, according to a study published online Aug. 29 in Diabetes Care.

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Healthy Gut Microbiome Compromised in ICU Patients

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Dysbiosis from unexpected environmental sources is seen within days after intensive care unit (ICU) admission, according to a study published online Aug. 31 in mSphere.

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Physician's Briefing
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