Two Prognostic Models for Very Preterm Birth Validated
Models for stillbirth, neonatal death, show good performance in large cohort in the Netherlands
MONDAY, Dec. 12 (HealthDay News) -- Prognostic models for stillbirth and neonatal death in very preterm infants demonstrated good performance in the Netherlands, according to a study published online Dec. 12 in Pediatrics.
Ewoud Schuit, from the Erasmus Medical Center in Rotterdam, Netherlands, and colleagues validated the two prognostic models in very preterm infants who were either known to be alive at the onset of labor (17,582 infants) or admitted for neonatal intensive care (11,578 infants). Infants with a gestational age of 22 to 32 weeks, and born in the Netherlands from 2000 through 2007, were included. The main outcome measure for infants known to be alive at the onset of labor was stillbirth or death within 28 days; and for infants admitted to intensive care the main outcome measure was death before discharge from the neonatal intensive care unit.
The investigators found that 16.7 percent of infants known to be alive at the beginning of labor died during labor or within 28 days of birth. Of the infants admitted for neonatal intensive care, 7.8 percent died before discharge. Good calibration and excellent discrimination was seen for the prognostic model for infants known to be alive at the onset of labor (c statistic, 0.92). Good calibration and good discrimination was seen with the model for those admitted for neonatal intensive care (c statistic, 0.82).
"The two prognostic models for stillbirth and neonatal death in very preterm Dutch infants showed good performance," the authors write.