THURSDAY, Jan. 7 (HealthDay News) -- The future development of type 2 diabetes mellitus (T2DM) or hyperglycemia may be predictable in children through routine pediatric exams and lab tests, according to a pair of studies in the January Archives of Pediatrics & Adolescent Medicine.
John A. Morrison, Ph.D., of the Cincinnati Children's Hospital Medical Center, and colleagues tracked 1,067 girls (starting at 10 years of age) in the National Growth and Health Study (NGHS) and 822 children (aged 6 to 18 years) in the Princeton Follow-up Study (PFS), and correlated common pediatric measures and tests to T2DM at ages 19 and 39 years. In the NGHS, insulin in the top fifth percentile was the strongest T2DM predictor, while in the PFS, body mass index (BMI) and systolic blood pressure in the top fifth percentile, parental diabetes history, glucose of at least 100 mg/dL, and high triglycerides were predictors of eventual T2DM.
Zhen Tian, M.D., of Tianjin Women and Children's Health Center in China, and colleagues studied 619 obese and 617 non-obese children (aged 3 to 6 years). Children who slept eight hours or less had a higher risk of hyperglycemia (fasting glucose level ≥100 mg/dL) than those sleeping nine or 10 hours (odds ratio, 1.65), while those who slept more than eight hours and were obese (BMI z score ≥1.65) had further increased risk (odds ratio, 2.12).
"Office-based childhood measures predict the presence and absence of future T2DM nine and 26 years after baseline. Childhood insulin measurement improves prediction, facilitating approaches to primary prevention of T2DM," Morrison and colleagues conclude.
Abstract - Morrison
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Abstract - Tian
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