Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for April 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Symptomatic Health Care Staff in U.K. Screened for COVID-19
THURSDAY, April 30, 2020 (HealthDay News) -- Screening symptomatic health care workers for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is feasible during the pandemic, according to a research letter published online April 22 in The Lancet.
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Remdesivir May Accelerate Recovery From Severe COVID-19
THURSDAY, April 30, 2020 (HealthDay News) -- Remdesivir may speed time to clinical improvement for patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, although results are conflicting, according to a study published online April 29 in The Lancet and press releases issued regarding a National Institutes of Health (NIH)-sponsored study.
Abstract/Full Text - Wang (subscription or payment may be required)
Editorial (subscription or payment may be required)
Press Release
Psoriasis Tied to Higher Alzheimer Disease Risk
THURSDAY, April 30, 2020 (HealthDay News) -- The incidence of Alzheimer disease (AD) is significantly higher in patients with psoriasis versus individuals without psoriasis, according to a Korean study published online April 15 in Scientific Reports.
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David Shulkin, M.D., on COVID-19 Financial Consequences for Health Care System
MONDAY, April 27, 2020 (HealthDay News) -- Health care organizations are facing hard financial decisions amid the COVID-19 pandemic, but an end is in sight as some are beginning to slowly open back up around the country, according to David Shulkin, M.D. Shulkin, who served as ninth secretary for Veterans Affairs and is former president and CEO of Beth Israel Medical Center in New York, spoke with HealthDay during a live stream on the HealthDay YouTube channel and live blog.
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KIMT3 Article
USPSTF: Behavioral Interventions Likely Prevent Tobacco Use
WEDNESDAY, April 29, 2020 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) concludes that primary care-feasible behavioral interventions have a moderate net benefit for preventing tobacco use in children. These findings form the basis of a final recommendation statement, published online April 28 in the Journal of the American Medical Association.
Evidence Report (subscription or payment may be required)
Recommendations (subscription or payment may be required)
Editorial (subscription or payment may be required)
Thromboembolic Complications in COVID-19 Discussed
WEDNESDAY, April 29, 2020 (HealthDay News) -- Prevention, diagnosis, and therapeutic management of thromboembolic complications in COVID-19 are discussed in a report published online April 23 in Radiology.
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Low Vitamin D, Smoking Predict Worse Cognitive Function in MS
WEDNESDAY, April 29, 2020 (HealthDay News) -- For multiple sclerosis (MS) patients with clinically isolated syndrome, lower vitamin D and smoking predict worse long-term cognitive function and neuronal integrity, according to a study published online April 16 in Neurology.
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National Coronavirus Testing Strategy Announced as U.S. Cases Top 1 Million
TUESDAY, April 28, 2020 (HealthDay News) -- While health experts continued to call for a national strategy to test more Americans for coronavirus, President Donald Trump on Monday announced a "blueprint" for boosting testing capacity as some states began reopening their economies.
Washington Post Article
CBS News Article
New York Times Article
Low Vitamin D May Reduce Survival for Some With Multiple Myeloma
TUESDAY, April 28, 2020 (HealthDay News) -- Vitamin D deficiency is associated with reduced overall survival for patients with multiple myeloma (MM), with a differential effect across race, according to a study published online April 21 in Blood Advances.
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Adding High-Dose Chloroquine Not Advised for Severe COVID-19
TUESDAY, April 28, 2020 (HealthDay News) -- High-dosage chloroquine diphosphate (CQ) has potential safety hazards when used as adjunctive therapy for patients hospitalized with severe COVID-19, according to a study published online April 24 in JAMA Network Open.
Abstract/Full Text
Editorial
Diabetes Medication Prescribing Increased 2003 to 2016
TUESDAY, April 28, 2020 (HealthDay News) -- Pharmacologic treatment for type 2 diabetes increased from 2003 to 2016, according to a study published online March 31 in Diabetes Care.
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FDA Warns of Bogus Claims by Makers of Hand Sanitizer
MONDAY, April 27, 2020 (HealthDay News) -- Some companies are selling hand sanitizers with unproven claims that they will protect against COVID-19, the U.S. Food and Drug Administration warns.
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WHO: No Evidence COVID-19 Survivors Cannot Be Reinfected
MONDAY, April 27, 2020 (HealthDay News) -- There is "no evidence" that people who have recovered from COVID-19 cannot be reinfected with the severe acute respiratory syndrome coronavirus 2, according to the World Health Organization.
CBS News Article
CNN Article
More Information: CDC
Direct Medical Costs of COVID-19 Infection Are Considerable
MONDAY, April 27, 2020 (HealthDay News) -- A single symptomatic COVID-19 infection results in direct medical costs of $3,045 in the United States, according to a study published online April 23 in Health Affairs.
Abstract/Full Text
Racial Differences Found in Managing Children's Pain From Broken Bones
MONDAY, April 27, 2020 (HealthDay News) -- There are racial differences in pain management and pain outcomes for children seen in the emergency department for long-bone fractures, according to a study published online April 20 in Pediatrics.
Abstract/Full Text
Physician's Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 20 to 24, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Premature Posting of Remdesivir Findings Were 'Inconclusive'
FRIDAY, April 24, 2020 (HealthDay News) -- Inconclusive findings from a study investigating the antiviral drug remdesivir as a treatment for COVID-19 were posted to the World Health Organization website "prematurely," drug maker Gilead Sciences said Thursday.
CNN Article
FDA Warns About Treating COVID-19 With Unproven Drugs
FRIDAY, April 24, 2020 (HealthDay News) -- Malaria drugs touted by some as potential "game changers" against COVID-19 are actually too dangerous for general use, the U.S. Food and Drug Administration warned Americans on Friday.
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COVID-19-Linked Changes Reported in Rheumatic Disease Patient Care
FRIDAY, April 24, 2020 (HealthDay News) -- Changes to health care have been reported among patients with rheumatic diseases during the COVID-19 pandemic, according to a study published online April 20 in ACR: Open Rheumatology.
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Low Doses of Bevacizumab Tested for Retinopathy of Prematurity
FRIDAY, April 24, 2020 (HealthDay News) -- For treatment of retinopathy of prematurity (ROP), 0.004 mg may be the lowest effective dose of bevacizumab, according to a study published online April 23 in JAMA Ophthalmology.
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Review: MMR, MMRV, MMR+V Vaccines Are Effective, Safe
FRIDAY, April 24, 2020 (HealthDay News) -- Measles, mumps, and rubella (MMR) vaccines and MMR vaccines with varicella are effective and safe, according to an updated review published online April 20 in the Cochrane Database of Systematic Reviews.
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White House Announces Payment Plan for Uninsured COVID-19 Patients
THURSDAY, April 23, 2020 (HealthDay News) -- A plan to begin paying hospitals and doctors who treat uninsured COVID-19 patients was announced by U.S. Health and Human Services Secretary Alex Azar on Wednesday.
AP News Article
'Health Force' to Combat Pandemic Proposed by U.S. Senators
THURSDAY, April 23, 2020 (HealthDay News) -- A bill to create a "Health Force" to help combat the U.S. COVID-19 outbreak has been announced by two Democratic senators.
NBC News Article
ACEIs/ARBs Not Linked to Severity or Mortality of COVID-19
THURSDAY, April 23, 2020 (HealthDay News) -- For patients with hypertension hospitalized with COVID-19 infections, angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) are not associated with the severity or mortality of COVID-19, according to a brief report published online April 23 in JAMA Cardiology.
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Clascoterone Cream Safe, Effective for Acne Treatment
THURSDAY, April 23, 2020 (HealthDay News) -- Clascoterone cream, 1 percent, appears to be safe and effective for the treatment of acne, according to a study published online April 22 in JAMA Dermatology.
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Editorial
Lopinavir/Ritonavir, Umifenovir Ineffective for Mild COVID-19
THURSDAY, April 23, 2020 (HealthDay News) -- For patients hospitalized with mild/moderate COVID-19, lopinavir/ritonavir (LPV/r) or umifenovir (Arbidol) monotherapy offers little benefit, according to a study published online April 17 in Med.
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Higher Manganese Intake May Be Tied to Lower Type 2 Diabetes Risk
THURSDAY, April 23, 2020 (HealthDay News) -- Higher intake of manganese is associated with a lower type 2 diabetes risk among postmenopausal women, independent of known risk factors, according to a study published online April 15 in Diabetes Care.
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Hydroxychloroquine Seems Not to Cut Ventilator Use in COVID-19
WEDNESDAY, April 22, 2020 (HealthDay News) -- There is no evidence that use of hydroxychloroquine alone (HC) or with azithromycin (HC+AZ) reduces the risks for mechanical ventilation or death from any cause in patients hospitalized with COVID-19, according to a study that has not yet been peer reviewed and was posted online April 21 at medRxiv.org.
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Rapid COVID-19 Test Can Produce False Negatives
WEDNESDAY, April 22, 2020 (HealthDay News) -- A widely used rapid COVID-19 test can produce false negatives if a certain solution is used to move or store patients' samples, the test's maker said.
CNN Article
Expert Panel: There Are No Proven Drug Treatments for COVID-19
WEDNESDAY, April 22, 2020 (HealthDay News) -- There is no proven drug treatment for COVID-19 patients, according to a panel of experts convened by the U.S. National Institute of Allergy and Infectious Diseases.
The New York Times Article
IBD Symptoms in Pregnancy Tied to Higher C-Section Rate, IUGR
WEDNESDAY, April 22, 2020 (HealthDay News) -- Women with inflammatory bowel disease (IBD) have lower pregnancy rates, and those with uncontrolled disease are at increased risk for adverse outcomes, according to a study published online April 7 in Alimentary Pharmacology and Therapeutics.
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FDA Authorizes COVID-19 Test That Uses Samples Collected at Home
TUESDAY, April 21, 2020 (HealthDay News) -- The U.S. Food and Drug Administration has approved emergency use of the first COVID-19 test that enables patients to take samples at home.
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LA County COVID-19 Infections Far Exceed Number of Confirmed Cases
TUESDAY, April 21, 2020 (HealthDay News) -- An early analysis of antibody testing from Los Angeles County reveals a COVID-19 infection rate that is up to 55 times the number of confirmed COVID-19 cases.
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Physicians Report Low Interest in Opioid Use Disorder Meds
TUESDAY, April 21, 2020 (HealthDay News) -- Few primary care physicians report interest in treating patients with opioid use disorder (OUD), according to a research letter published online April 21 in the Annals of Internal Medicine.
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Cardiac Cath Lab STEMI Activations Drop During Pandemic
TUESDAY, April 21, 2020 (HealthDay News) -- During the COVID-19 pandemic, there has been a 38 percent reduction in U.S. cardiac catheterization laboratory ST-segment elevation myocardial infarction (STEMI) activations, according to a research letter published online April 10 in the Journal of the American College of Cariology.
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Lab Protocol Failures Led to Ineffective COVID-19 Tests From CDC
MONDAY, April 20, 2020 (HealthDay News) -- The first COVID-19 tests in the United States were ineffective due to poor laboratory practices at the U.S. Centers for Disease Control and Prevention, the U.S. Food and Drug Administration said.
The New York Times Article
Benefit of Social Distancing Outweighs Economic Impact
MONDAY, April 20, 2020 (HealthDay News) -- The economic benefits of lives saved through social distancing substantially outweigh the value of the projected losses to the U.S. economy, according to a study to be published in a forthcoming issue of the Journal of Benefit-Cost Analysis.
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Physician's Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 13 to 17, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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CDC Looks at Transmission of COVID-19 to Health Care Workers
FRIDAY, April 17, 2020 (HealthDay News) -- Transmission of coronavirus disease 2019 (COVID-19) to health care personnel (HCP) is explored in two studies published in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
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IDSA Issues Rapid Guidelines for Treatment of COVID-19
FRIDAY, April 17, 2020 (HealthDay News) -- In rapid guidelines issued by the Infectious Diseases Society of America (IDSA), recommendations are presented for the treatment and management of coronavirus disease 2019 (COVID-19).
Abstract/Full Text
Probiotics May Help Reduce Mild-to-Moderate Acne Symptoms
FRIDAY, April 17, 2020 (HealthDay News) -- The use of probiotics as an adjunct therapy may help in the management of acne vulgaris, according to a review published online April 7 in Dermatologic Therapy.
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Recurrent Winter Outbreaks of SARS-CoV-2 Projected
THURSDAY, April 16, 2020 (HealthDay News) -- Recurrent winter outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) are projected to occur after the initial pandemic wave, according to a study published online April 14 in Science.
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Sharp Drop in Demand Seen for COVID-19 Tests at Private Labs
THURSDAY, April 16, 2020 (HealthDay News) -- There has been such a drop in demand for coronavirus disease 2019 (COVID-19) tests at private labs in the United States that they have "considerable" unused capacity and can test more patients with less severe symptoms, the American Clinical Laboratory Association (ACLA) says.
NBC News Article
CRISPR-Based Test Can Diagnose COVID-19 in Under 60 Minutes
THURSDAY, April 16, 2020 (HealthDay News) -- Researchers say they have developed a low-cost swab test that can diagnose coronavirus disease 2019 (COVID-19) infections in about 45 minutes.
Abstract/Full Text
FDA Urges COVID-19 Survivors to Donate Plasma
THURSDAY, April 16, 2020 (HealthDay News) -- The U.S. Food and Drug Administration is asking Americans who have recovered from coronavirus disease 2019 (COVID-19) to donate their blood plasma to help fight the pandemic.
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American Red Cross
Novel Agent Promising for the Treatment of Schizophrenia
THURSDAY, April 16, 2020 (HealthDay News) -- For patients with an acute exacerbation of schizophrenia, SEP-363856, a non-D2-receptor-binding drug that has agonist activity at trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A receptors, reduces Positive and Negative Symptom Scale (PANSS) total score more than placebo, according to a study published in the April 16 issue of the New England Journal of Medicine.
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Editorial (subscription or payment may be required)
Quality Improvement Effort Cuts Blood Clots in Brain Injury Patients
THURSDAY, April 16, 2020 (HealthDay News) -- Implementation of an anticoagulation protocol reduces blood clots in patients with traumatic brain injury (TBI), according to a study published in the April 1 issue of The Joint Commission Journal on Quality and Patient Safety.
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Editorial (subscription or payment may be required)
Post-Detox Treatment Lowers Mortality in Opioid Use Disorder
WEDNESDAY, April 15, 2020 (HealthDay News) -- People who receive additional treatment following medically managed opioid withdrawal have reduced mortality compared with those who do not receive treatment, according to a study recently published in Addiction.
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Survey Shows Lack of COVID-19 Concern Even Among Those at Risk
WEDNESDAY, April 15, 2020 (HealthDay News) -- Many individuals at greater risk for coronavirus disease 2019 (COVID-19) complications did not believe the virus would affect them at the beginning of Chicago's outbreak, according to a study published online April 9 in the Annals of Internal Medicine.
Abstract/Full Text
Obesity Is Risk Factor for COVID-19 Hospital Admission in <60s
WEDNESDAY, April 15, 2020 (HealthDay News) -- Obesity is associated with admission to the hospital for coronavirus disease 2019 (COVID-19) patients, according to a study published online April 9 in Clinical Infectious Diseases and a study not yet peer reviewed and posted on medRxiv.org.
Abstract/Full Text - Lighter (subscription or payment may be required)
Abstract/Full Text - Petrilli (subscription or payment may be required)
Prognostic Score Predicts Time to First Treatment in Leukemia
WEDNESDAY, April 15, 2020 (HealthDay News) -- An international prognostic score (IPS-E) can predict time to first treatment (TTFT) for chronic lymphocytic leukemia (CLL) patients with early, asymptomatic disease, according to a study published online April 8 in Blood.
Abstract/Full Text
SARS-CoV-2 Contamination of Air, Surfaces Examined in ICU, Wards
WEDNESDAY, April 15, 2020 (HealthDay News) -- Considerable severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) contamination of air and object surfaces is reported in intensive care units (ICUs) and general coronavirus disease 2019 (COVID-19) wards (GW), according to a study published online April 10 in Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.
Abstract/Full Text
Public Health Interventions Improved COVID-19 Control in Wuhan
WEDNESDAY, April 15, 2020 (HealthDay News) -- Multifaceted public health interventions improved control of the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, according to a study published online April 10 in the Journal of the American Medical Association.
Abstract/Full Text
Editorial
Preoperative Metformin Tied to Better Surgical Outcomes
WEDNESDAY, April 15, 2020 (HealthDay News) -- Preoperative metformin prescriptions may be associated with decreased postoperative mortality and readmission among patients with diabetes undergoing a major surgical procedure, according to a study published online April 8 in JAMA Surgery.
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Editorial (subscription or payment may be required)
Common Coronaviruses Are Highly Seasonal
WEDNESDAY, April 15, 2020 (HealthDay News) -- Common coronaviruses circulate seasonally, according to a study published online April 4 in the Journal of Infectious Diseases.
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CDC: Overall Prevalence of Self-Reported Hypertension 32.4 Percent
WEDNESDAY, April 15, 2020 (HealthDay News) -- The overall prevalence of self-reported hypertension is 32.4 percent, with prevalence higher among men than women and among blacks, according to research published in the April 10 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
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Review: Quarantine Effective for Reducing Infection, Death
TUESDAY, April 14, 2020 (HealthDay News) -- Quarantine is effective for reducing the number of people infected and deaths from coronavirus disease 2019 (COVID-19), according to a review published online April 8 in the Cochrane Database of Systematic Reviews.
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U.S. Government Says COVID-19 Antibody Tests Must Be Free
TUESDAY, April 14, 2020 (HealthDay News) -- Health insurers and Medicaid must provide free coverage for tests to detect coronavirus 2019 (COVID-19) antibodies in people who have been infected, the federal government says.
CBS News Article
Johns Hopkins University
CDC: Public Policy Measures Important for Social Distancing
TUESDAY, April 14, 2020 (HealthDay News) -- Community mobility in four metropolitan areas decreased with the introduction of public policy measures supporting social distancing, which could help slow the spread of coronavirus disease 2019 (COVID-19), according to research published in the April 13 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
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First Saliva Test for COVID-19 Approved by FDA
TUESDAY, April 14, 2020 (HealthDay News) -- The first saliva test for coronavirus 2019 (COVID-19) was approved Monday by the U.S. Food and Drug Administration.
AP News Article
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Medical Masks May Be Sufficient During COVID-19 Routine Care
TUESDAY, April 14, 2020 (HealthDay News) -- Use of medical masks, such as surgical or procedural masks, does not increase the risk for viral infection or respiratory illness, and their use may serve as a protective measure in instances of N95 respirator shortages, according to the results of a meta-analysis published online April 4 in Influenza and Other Respiratory Viruses.
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First Wave of COVID-19 Abated With Control Measures in China
TUESDAY, April 14, 2020 (HealthDay News) -- Interventions implemented in China interrupted coronavirus disease 2019 (COVID-19) transmission in all areas outside of Hubei, and low transmissibility can be maintained by monitoring the instantaneous effective reproduction number (Rt), according to a study published online April 8 in The Lancet.
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Editorial
Physicians Report Expanding Use of Off-Label COVID-19 Treatments
MONDAY, April 13, 2020 (HealthDay News) -- Hydroxychloroquine usage is expanding globally to treat coronavirus 2019 (COVID-19), although plasma from recovered patients is perceived as more effective than hydroxychloroquine, according to a report released by Sermo.
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Chloroquine COVID-19 Trial Stopped After Patient Deaths
MONDAY, April 13, 2020 (HealthDay News) -- A study of chloroquine in coronavirus 2019 (COVID-19) patients was halted due to potentially deadly side effects.
The New York Times Article
COVID-19 Antibody Tests Underway in California
MONDAY, April 13, 2020 (HealthDay News) -- Large-scale studies of tests to check for antibodies to coronavirus 2019 (COVID-19) are underway in California. The findings from this research could help the United States develop strategies to get people back to work and restart the economy.
NBC News Article
Remdesivir May Improve Oxygen-Support Class in Severe COVID-19
MONDAY, April 13, 2020 (HealthDay News) -- Improvement in oxygen support status was observed in 68 percent of patients hospitalized with severe coronavirus disease 2019 (COVID-19) who received compassionate use of remdesivir, according to a study published online April 10 in the New England Journal of Medicine.
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CDC Report Details Geographic Variation in U.S. COVID-19 Cases, Deaths
MONDAY, April 13, 2020 (HealthDay News) -- There is variation in the cumulative incidence of coronavirus disease 2019 (COVID-19) across jurisdictions in the United States, according to research published in the April 10 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
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Most Home BP Devices Available Online Are Not Validated
MONDAY, April 13, 2020 (HealthDay News) -- Most home blood pressure (BP) devices available online are nonvalidated, and they are sold at a lower cost than validated ones, according to a study published online April 13 in Hypertension.
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Physician's Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 6 to 10, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Neurologic Effects Seen in a Third of Hospitalized COVID-19 Patients
FRIDAY, April 10, 2020 (HealthDay News) -- Neurologic manifestations are common among hospitalized patients with COVID-19, according to a study published online April 10 in JAMA Neurology.
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Editorial
FDA Approves New Way to Decontaminate N95 Face Masks
FRIDAY, April 10, 2020 (HealthDay News) -- The second emergency use authorization to decontaminate N95 face masks and equivalents for reuse by hospital health care workers has been issued by the U.S. Food and Drug Administration.
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Temperature, UV Radiation Not Linked to Incidence of COVID-19
FRIDAY, April 10, 2020 (HealthDay News) -- Ambient temperature and ultraviolet (UV) radiation are not associated with the cumulative incidence rate or basic reproduction number (R0) of coronavirus disease 2019 (COVID-19), according to a research letter published online April 8 in the European Respiratory Journal.
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Current Models for COVID-19 Diagnosis, Prognosis Unreliable
FRIDAY, April 10, 2020 (HealthDay News) -- Novel coronavirus (COVID-19)-related models that are published in the literature are poorly reported and at high risk for bias, raising concern that their predictions could be unreliable when applied in daily practice, according to a review published online April 7 in The BMJ.
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Anxiety Up for Nonmedical Health Care Workers Versus Those on Front Lines
FRIDAY, April 10, 2020 (HealthDay News) -- Non-medically trained health care workers caring for patients with coronavirus disease 2019 (COVID-19) have an increased prevalence of anxiety compared with medically trained health care workers, according to a research letter published online April 6 in the Annals of Internal Medicine.
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Face Masks Offer Slight Protective Effect From Flu-Like Illness
FRIDAY, April 10, 2020 (HealthDay News) -- Wearing face masks could be slightly protective against primary infection with influenza-like illness from casual community contact, according to a review that has not yet been peer reviewed and was posted online April 6 at medRxiv.org.
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Incident Depression Increases With Body Mass Index
FRIDAY, April 10, 2020 (HealthDay News) -- The risk for incident depression increases with body mass index (BMI) among overweight and obese patients, according to a study published online April 8 in Obesity.
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Clinical Trial Underway to Test Nitric Oxide in COVID-19 Patients
THURSDAY, April 9, 2020 (HealthDay News) -- Doctors at the University of Alabama at Birmingham (UAB) are enrolling patients in an international clinical trial to find out if inhaled nitric oxide benefits those with novel coronavirus (COVID-19) who have severely damaged lungs.
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NIH Launches Clinical Trial of Hydroxychloroquine for COVID-19
THURSDAY, April 9, 2020 (HealthDay News) -- A clinical trial to assess the antimalarial drug hydroxychloroquine as a treatment for adults with the novel coronavirus (COVID-19) is now underway, the U.S. National Institutes of Health said Thursday.
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COVID-19 Came to New York City From Europe, Not Asia
THURSDAY, April 9, 2020 (HealthDay News) -- The novel coronavirus (COVID-19) has been circulating in New York City for longer than previously believed and most cases can be traced back to Europe, new research reveals.
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Johns Hopkins University
FDA Warns of False Claims That Chlorine Dioxide Can Treat COVID-19
THURSDAY, April 9, 2020 (HealthDay News) -- A warning letter has been sent to a company marketing fraudulent and dangerous chlorine dioxide products for the prevention and treatment of the novel coronavirus (COVID-19), the U.S. Food and Drug Administration says.
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Another COVID-19 Vaccine Trial Begins in the United States
THURSDAY, April 9, 2020 (HealthDay News) -- Another clinical trial of an experimental vaccine for the novel coronavirus 2019 (COVID-19) has been launched by U.S. researchers.
AP News Article
ATS Provides Interim Guidance for Management of COVID-19
THURSDAY, April 9, 2020 (HealthDay News) -- In a guidance document issued by the American Thoracic Society, interim recommendations are presented for management of coronavirus disease 2019 (COVID-19).
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'Dead' Probiotic Treatment May Help Reduce Irritable Bowel Symptoms
THURSDAY, April 9, 2020 (HealthDay News) -- Probiotic treatment with dead bacteria is better than placebo at alleviating symptoms of irritable bowel syndrome (IBS), according to a study published online April 8 in The Lancet Gastroenterology & Hepatology.
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Editorial (subscription or payment may be required)
Outcomes Better at One Year With Physical Therapy for Knee OA
THURSDAY, April 9, 2020 (HealthDay News) -- For patients with osteoarthritis of the knee, those undergoing physical therapy have less pain and functional disability at one year compared with those who receive an intraarticular glucocorticoid injection, according to a study published in the April 9 issue of the New England Journal of Medicine.
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Suppressing Stomach Acid May Up Intestinal Growth of MDROs
THURSDAY, April 9, 2020 (HealthDay News) -- Stomach acid suppression medications increase the odds of intestinal colonization with multidrug-resistant microorganisms (MDROs), according to a review and meta-analysis recently published in JAMA Internal Medicine.
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Editorial (subscription or payment may be required)
COVID-19 Killing Two Times More Men Than Women in NYC
WEDNESDAY, April 8, 2020 (HealthDay News) -- The novel coronavirus (COVID-19) death rate in New York City is two times higher among men than among women, and men also have higher rates of infection and hospitalization, new data show.
The New York Times Article
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CDC Removes Prescribing Guidelines for Antimalarial Drugs
WEDNESDAY, April 8, 2020 (HealthDay News) -- Guidelines for doctors on how to prescribe two antimalarial drugs that some believe may treat the novel coronavirus (COVID-19) are no longer available on the U.S. Centers for Disease Control and Prevention website.
CNN Article
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Surgical, Cotton Masks Not Effective for Filtering SARS-CoV-2
WEDNESDAY, April 8, 2020 (HealthDay News) -- For patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), neither surgical nor cotton masks effectively filter SARS-CoV-2 during coughs, according to a research letter published online April 6 in the Annals of Internal Medicine.
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Some Multidrug-Resistant Bacterial Infections Down in U.S.
WEDNESDAY, April 8, 2020 (HealthDay News) -- From 2012 to 2017, there were decreases in the incidence of some multidrug-resistant (MDR) bacterial infections in hospitalized patients in the United States, according to a study published in the April 2 issue of the New England Journal of Medicine.
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Side Effects Seen With Use of Chloroquine Against COVID-19
TUESDAY, April 7, 2020 (HealthDay News) -- The use of the antimalarial drug chloroquine to treat COVID-19 patients has been halted at several Swedish hospitals due to reported side effects such as cramps and loss of peripheral vision. Sahlgrenska University Hospital is one of those facilities. It stopped the use of chloroquine in the treatment of COVID-19 about two weeks ago.
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Serious Concerns Associated With COVID-19 Pandemic Reported
TUESDAY, April 7, 2020 (HealthDay News) -- Serious concerns are associated with coronavirus disease 2019 (COVID-19), and many individuals are preparing by washing hands and self-isolating, according to a research letter published online April 7 in JAMA Internal Medicine.
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Most COVID-19 Fatalities Are Men Over 50 With Chronic Disease
TUESDAY, April 7, 2020 (HealthDay News) -- Most fatal cases of coronavirus disease 2019 (COVID-19) occur in men aged older than 50 years with noncommunicable chronic diseases, according to a study published online April 3 in the American Journal of Respiratory and Critical Care Medicine.
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No Treatment Change Needed for Peds IBD During COVID-19 Pandemic
TUESDAY, April 7, 2020 (HealthDay News) -- Preliminary data regarding outcomes for pediatric patients with inflammatory bowel disease (IBD) during the coronavirus disease 2019 (COVID-19) outbreak are reassuring, according to research published online March 31 in the Journal of Pediatric Gastroenterology and Nutrition.
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School Closures Could Further Complicate COVID-19 Effort
TUESDAY, April 7, 2020 (HealthDay News) -- Potential contagion prevention from school closures needs to be weighed against the potential loss of health care workers due to child care obligations during the coronavirus disease 2019 (COVID-19) pandemic, according to a study published online April 3 in The Lancet Public Health.
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Radiotherapy for Prostate Cancer Adjusted During COVID-19
TUESDAY, April 7, 2020 (HealthDay News) -- In a special article published online April 1 in Advances in Radiation Oncology, a framework is laid out for the management of radiotherapy for prostate cancer patients during the coronavirus disease 2019 (COVID-19) pandemic.
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Initial Invasive Strategy No Better in Stable Coronary Disease
MONDAY, April 6, 2020 (HealthDay News) -- For patients with stable coronary disease and moderate-to-severe ischemia, an initial invasive strategy does not improve outcomes, but it may improve angina-related health status, according to two studies published online March 30 in the New England Journal of Medicine.
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FDA Authorizes Use of Chinese-Approved Masks in United States
MONDAY, April 6, 2020 (HealthDay News) -- Emergency use authorization of protective masks that do not meet American standards has been announced by the U.S. Food and Drug Administration.
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Majority of Physicians Report Serious Concerns About COVID-19
MONDAY, April 6, 2020 (HealthDay News) -- According to a national survey conducted by Harvard Medical School, the RAND Corporation, and Doximity, practicing physicians currently report substantial concerns about supplies, the government response, and availability of testing amid the COVID-19 pandemic.
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Comorbidity, Age, Time to Treatment Linked to COVID-19 Progression
MONDAY, April 6, 2020 (HealthDay News) -- Factors associated with coronavirus disease 2019 (COVID-19) progression include comorbidity, age, and time from illness onset to antiviral treatment, according to a study published online March 27 in the Journal of Internal Medicine.
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Hydroxychloroquine Can Shorten Time to Recovery in COVID-19
MONDAY, April 6, 2020 (HealthDay News) -- Hydroxychloroquine (HCQ) can shorten time to clinical recovery and promote pneumonia absorption among patients with coronavirus disease 2019 (COVID-19), according to a study that has not yet been peer reviewed and was posted online March 31 at medRxiv.org.
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Bacteremia Risk Higher in Older Patients Hospitalized With IBD
MONDAY, April 6, 2020 (HealthDay News) -- Older age is associated with an increased risk for bacteremia in hospitalized patients with inflammatory bowel disease (IBD), according to a study published in the March issue of the United European Gastroenterology Journal.
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Model Shows Hep C-Infected Kidney Transplants Beneficial, Cost-Effective
MONDAY, April 6, 2020 (HealthDay News) -- Transplanting hepatitis C virus (HCV)-infected kidneys into uninfected recipients and then treating patients with antiviral therapy leads to a higher quality of life and is less costly than waiting for transplantation with an uninfected kidney, according to a study recently published in the American Journal of Kidney Diseases.
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Physician's Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of March 30 to April 3, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Enrollment Begins in NIH-Sponsored Trial of Remdesivir for COVID-19 Patients
FRIDAY, April 3, 2020 (HealthDay News) -- A number of institutions this week announced their participation in an international clinical drug trial evaluating the safety and efficacy of remdesivir in hospitalized patients with the novel coronavirus 2019 (COVID-19).
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Test Vaccine Elicits Strong Ab Response to SARS-CoV-2 in Mice
FRIDAY, April 3, 2020 (HealthDay News) -- Microneedle array (MNA) delivery of trimeric coronavirus spike (S) protein subunit vaccines seems promising for immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, according to research published online April 2 in EBioMedicine.
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Model Projects COVID-19 Deaths in Italy Through Mid-April
FRIDAY, April 3, 2020 (HealthDay News) -- Modeling suggests that in Italy, the number of coronavirus disease 2019 (COVID-19) intensive care unit (ICU) patients will continue increasing into April, according to a report published April 1 by the European Society of Anaesthesiology.
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Rivaroxaban Prevents VTE After Lower-Limb Surgery
FRIDAY, April 3, 2020 (HealthDay News) -- Following nonmajor orthopedic surgery of the lower limb, rivaroxaban is superior to enoxaparin for prevention of major venous thromboembolism, according to a study published online March 29 in the New England Journal of Medicine.
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Early Deep Remission of Crohn Disease Tied to Better Outcomes
FRIDAY, April 3, 2020 (HealthDay News) -- Deep early remission of Crohn disease is associated with a significant decrease in long-term adverse effects, according to a study published online March 26 in Gastroenterology.
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Many Legal Marijuana Products Too Strong for Treating Pain
FRIDAY, April 3, 2020 (HealthDay News) -- Legally dispensed marijuana products have stronger concentrations of tetrahydrocannabinol (THC) and cannabidiol (CBD) than needed for chronic pain relief, according to a study published online March 26 in PLOS ONE.
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Unemployed Workers Less Likely to Be Uninsured Post-ACA
THURSDAY, April 2, 2020 (HealthDay News) -- Following implementation of the Affordable Care Act (ACA), unemployed workers were less likely to be uninsured, and uninsurance rates decreased more in states with Medicaid expansion, according to a report from the Urban Institute and the Robert Wood Johnson Foundation.
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Proton Pump Inhibitor Therapy May Up Fracture Risk in Children
THURSDAY, April 2, 2020 (HealthDay News) -- Proton pump inhibitors (PPIs) taken for acid reflux may lead to an increased risk for fractures in children and adolescents, according to a study published online March 12 in the Journal of Pediatric Gastroenterology and Nutrition.
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FDA Pulls Heartburn Drug Zantac From Market
WEDNESDAY, April 1, 2020 (HealthDay News) -- All versions of the heartburn drug Zantac (ranitidine) have been pulled from the U.S. market due to possible contamination with a probable human carcinogen, the U.S. Food and Drug Administration said Wednesday.
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Imported Masks, Other Medical Supplies Arriving in U.S.
WEDNESDAY, April 1, 2020 (HealthDay News) -- For the first time since February, imported N95 medical masks are arriving in the United States, but they are not nearly enough to meet demand as COVID-19 cases climb.
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U.S. Coronavirus Death Toll Could Reach 240,000, Task Force Warns
WEDNESDAY, April 1, 2020 (HealthDay News) -- The White House coronavirus task force delivered a tough statistic to Americans late Tuesday, warning that the U.S. death toll from COVID-19 could climb to 240,000, even with social distancing policies in place.
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ENDO: Liraglutide May Benefit Adolescents With Obesity
WEDNESDAY, April 1, 2020 (HealthDay News) -- Liraglutide plus lifestyle therapy results in a significantly greater reduction in body mass index (BMI) standard-deviation score than placebo among adolescents with obesity, according to a study published online March 31 in the New England Journal of Medicine to coincide with the virtual meeting of The Endocrine Society, held from March 28 to 31.
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Low Vitamin D May Reduce Mobility After Hip Fracture Surgery
WEDNESDAY, April 1, 2020 (HealthDay News) -- Vitamin D deficiencies are associated with a lower likelihood of older patients regaining independent walking ability following hip fracture surgery, according to a study recently published in the American Journal of Clinical Nutrition.
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Polypharmacy Ups Postchemo Hospitalization Risk in Seniors
WEDNESDAY, April 1, 2020 (HealthDay News) -- Older patients taking five or more medications in the six months before intravenous (IV) chemotherapy are at higher risk for postchemotherapy inpatient hospitalizations, according to a study published online March 18 in the Journal of Geriatric Oncology.
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