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March 2017 Briefing - Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for March 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Vertical Integration Insurance Products of Higher Quality

FRIDAY, March 31, 2017 (HealthDay News) -- Insurance products offered by hospitals and health systems, known as vertical integration, are generally of higher quality than other contracts, according to a study published in the March issue of Health Affairs.

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Estriol Gel Aids Vaginal Health Pre, Post Genital Prolapse Sx

FRIDAY, March 31, 2017 (HealthDay News) -- For postmenopausal women undergoing surgical treatment for pelvic organ prolapse, vaginal estriol gel is associated with improvement in vaginal health, according to a study published online March 27 in Menopause.

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Quinolone Ear Drops Increase Perforation Risk With Ear Tubes

FRIDAY, March 31, 2017 (HealthDay News) -- Children with tympanostomy tube (TT) placement exposed to quinolone ear drops may have an increased risk of perforations requiring tympanoplasty, according to a study published in the April 15 issue of Clinical Infectious Diseases.

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Cediranib Tx in Relapsed Ovarian CA Doesn't Lower Quality of Life

FRIDAY, March 31, 2017 (HealthDay News) -- Maintenance therapy with cediranib for women with relapsed ovarian cancer is not detrimental to quality of life (QOL), according to a study published online March 24 in Cancer.

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Overall Risk of VTE Recurrence Similar for iSVT, Proximal DVT

FRIDAY, March 31, 2017 (HealthDay News) -- Patients with isolated superficial vein thrombosis (iSVT) have a similar overall risk of recurrence as those with proximal deep vein thrombosis (DVT), according to a study published online March 20 in the Journal of Thrombosis and Haemostasis.

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Extreme Preemies Benefit Most From Corticosteroids Before Birth

THURSDAY, March 30, 2017 (HealthDay News) -- Among infants born from 23 to 34 weeks of gestation, antenatal exposure to corticosteroids is associated with lower mortality and morbidity at most gestations, according to a study published online March 28 in The BMJ.

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Apixaban Tx Cost in A-Fib Meets U.S. Norms for Reasonable Value

THURSDAY, March 30, 2017 (HealthDay News) -- Apixaban therapy is cost-effective for atrial fibrillation from the perspective of the U.S. health care system, according to a study published online March 29 in JAMA Cardiology.

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Hep B, C Could Be Eliminated As Public Health Threats by 2030

THURSDAY, March 30, 2017 (HealthDay News) -- Hepatitis B and C could be eliminated as serious public health problems in the United States by 2030, according to a report from the National Academies of Sciences, Engineering, and Medicine.

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Proton Pump Inhibitor Use Ups Pneumonia Risk in Dementia

THURSDAY, March 30, 2017 (HealthDay News) -- For patients with dementia, proton pump inhibitor (PPI) use is associated with increased risk of pneumonia, according to a study published online March 21 in the Journal of the American Geriatrics Society.

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Inadvertent HPV Vax Doesn't Up Risk of Poor Pregnancy Outcomes

WEDNESDAY, March 29, 2017 (HealthDay News) -- Exposure to the quadrivalent human papillomavirus (HPV) vaccine during pregnancy is not associated with adverse pregnancy outcomes, according to a study published in the March 30 issue of the New England Journal of Medicine.

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FDA Approves Ocrevus to Treat Severe Form of Multiple Sclerosis

WEDNESDAY, March 29, 2017 (HealthDay News) -- The intravenous drug Ocrevus (ocrelizumab) has been approved by the U.S. Food and Drug Administration to treat adults with primary progressive multiple sclerosis (PPMS) and relapsing forms of the disease, the agency said Wednesday in a news release.

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DAPT Cessation Patterns Vary With Diabetes Status After PCI

WEDNESDAY, March 29, 2017 (HealthDay News) -- For patients undergoing dual antiplatelet therapy (DAPT) after percutaneous coronary intervention with a drug-eluting stent (DES), DAPT cessation is significantly lower in patients with diabetes mellitus (DM), according to a study published in the March 27 issue of JACC: Cardiovascular Interventions.

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FDA Approves Dupixent to Treat Eczema

WEDNESDAY, March 29, 2017 (HealthDay News) -- Dupixent (dupilumab) has been approved by the U.S. Food and Drug Administration to treat moderate-to-severe eczema that isn't well controlled by topical medication.

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Substance Abuse Is a Treatable Chronic Medical Condition

WEDNESDAY, March 29, 2017 (HealthDay News) -- In a position paper published online March 28 in the Annals of Internal Medicine, recommendations are presented for the prevention and treatment of substance use disorders.

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FDA Approves Zejula for Certain Female Cancers

TUESDAY, March 28, 2017 (HealthDay News) -- Zejula (niraparib) has been approved by the U.S. Food and Drug Administration to treat adult women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancers whose tumors have shrunk in response to platinum-based chemotherapy.

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TV Ads for ACA Enrollment Linked to Decline in Uninsured Rates

TUESDAY, March 28, 2017 (HealthDay News) -- The volume of insurance advertisements during the first Affordable Care Act enrollment period correlated with change in uninsurance rates, with a higher volume of television advertisements linked to declines in uninsurance, according to a study published online March 15 in Health Affairs.

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Teens Exposed to Opioid Rx at Risk for Serious Outcomes

TUESDAY, March 28, 2017 (HealthDay News) -- Teenagers with prescription opioid exposures are more likely to have health care facility (HCF) admission and serious medical outcomes than younger children, according to a study published online March 20 in Pediatrics.

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Novel Oral Budesonide Prep Treats Eosinophilic Esophagitis

TUESDAY, March 28, 2017 (HealthDay News) -- Budesonide oral suspension (BOS) is associated with improvement in symptomatic, endoscopic, and histologic parameters in adolescent and young adult patients with eosinophilic esophagitis (EoE), according to a study published in the March issue of Gastroenterology.

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ACP Issues Challenge to Cut Task Burden and Put Patients First

TUESDAY, March 28, 2017 (HealthDay News) -- In a position paper published online March 28 in the Annals of Internal Medicine, recommendations are presented to address the impact of administrative tasks and reduce the administrative burden on clinicians.

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Cancer Patients Vary in Survival Benefit Needed to Justify Chemo

MONDAY, March 27, 2017 (HealthDay News) -- Among patients participating in a chemotherapy drug trial, there is substantial variation in preferences regarding length of survival benefits that justify undergoing chemotherapy, according to a study published online March 21 in Cancer.

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Gastric Acid Suppressants May Up Risk of Recurrent C. difficile

MONDAY, March 27, 2017 (HealthDay News) -- Use of gastric acid suppressants may increase the risk of recurrent Clostridium difficile infection (CDI), according to a meta-analysis published online March 27 in JAMA Internal Medicine.

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Long-Term Thrombolytic Tx No Benefit in Intermediate-Risk PE

MONDAY, March 27, 2017 (HealthDay News) -- Among patients with intermediate- to high-risk pulmonary embolism (PE), thrombolytic treatment with tenecteplase does not affect long-term mortality rates or rates of other complications, according to a study published in the March 28 issue of the Journal of the American College of Cardiology.

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Review: Several Classes of Drugs Treat Pain of Diabetic Neuropathy

MONDAY, March 27, 2017 (HealthDay News) -- Several classes of drugs reduce neuropathy-related pain better than placebo, according to a review published online March 24 in Neurology.

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Suicide Risk Not Up With New Rx of 5α-Reductase Inhibitor for BPH

MONDAY, March 27, 2017 (HealthDay News) -- For older men, initiation of a new prescription of a 5α-reductase inhibitor for the treatment of benign prostatic hyperplasia is not associated with increased risk of suicide, according to a study published online March 20 in JAMA Internal Medicine.

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Increased Use of Newer Meds for Diabetic Nephropathy in the U.S.

MONDAY, March 27, 2017 (HealthDay News) -- From 2010 to 2014 there was an increase in use of diabetes medications, including sulfonylureas and dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), among patients with diabetic nephropathy, according to a study published online March 15 in the Journal of Clinical Pharmacy and Therapeutics.

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Recent Decline in Prescription Opioid Use Among U.S. Teens

FRIDAY, March 24, 2017 (HealthDay News) -- For adolescents, medical and nonmedical use of prescription opioids has declined in recent years, according to a study published online March 20 in Pediatrics.

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Inositol Supplements Don't Prevent Gestational Diabetes

FRIDAY, March 24, 2017 (HealthDay News) -- Inositol supplementation in early pregnancy does not prevent gestational diabetes mellitus (GDM) in women with a family history of diabetes, according to a study published online March 21 in Diabetes Care.

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FDA Approves Bavencio for Merkel Cell Carcinoma

THURSDAY, March 23, 2017 (HealthDay News) -- Bavencio (avelumab) has been approved by the U.S. Food and Drug Administration to treat Merkel cell carcinoma (MCC), the agency said Thursday in a news release.

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30-Day Mortality Down During Joint Commission Survey Weeks

THURSDAY, March 23, 2017 (HealthDay News) -- Patients admitted to the hospital during The Joint Commission on-site inspections (surveys) have reduced mortality compared to that seen during non-survey weeks, according to research published online March 20 in JAMA Internal Medicine.

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Statin Intolerance Tied to Increased Risk of Recurrent MI

THURSDAY, March 23, 2017 (HealthDay News) -- For Medicare beneficiaries after myocardial infarction (MI) hospitalization, statin intolerance is associated with increased risk of recurrent MI and coronary heart disease (CHD) events, according to a study published in the March 21 issue of the Journal of the American College of Cardiology.

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CANA/PHEN Aids Weight Loss in Obese Without Type 2 Diabetes

THURSDAY, March 23, 2017 (HealthDay News) -- For obese or overweight individuals without type 2 diabetes, coadministration of canagliflozin (CANA) and phentermine (PHEN) is associated with considerable weight loss and is well tolerated, according to a study published online March 13 in Diabetes Care.

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Review: Treatment Options for Benzodiazepine Dependence

THURSDAY, March 23, 2017 (HealthDay News) -- Effective treatment of benzodiazepine dependence includes cognitive behavioral therapy and motivational approaches, according to a study published in the March 22 issue of the New England Journal of Medicine.

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C1 Inhibitor Use Reduces Attacks in Hereditary Angioedema

THURSDAY, March 23, 2017 (HealthDay News) -- Prophylactic use of the subcutaneous C1 inhibitor CSL830 is associated with a reduction in the frequency of acute attacks in patients with hereditary angioedema, according to a study published in the March 23 issue of the New England Journal of Medicine.

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Perinatal HIV Infection Down in U.S. From 2002 to 2013

THURSDAY, March 23, 2017 (HealthDay News) -- The estimated annual number of perinatal HIV-infected infants born in the United States decreased from 2002 to 2013, according to a study published online March 20 in JAMA Pediatrics.

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Pregabalin Doesn't Cut Intensity of Sciatica-Linked Leg Pain

WEDNESDAY, March 22, 2017 (HealthDay News) -- Pregabalin does not significantly reduce the intensity of leg pain associated with sciatica, according to a study published in the March 23 issue of the New England Journal of Medicine.

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FDA Approves New Parkinson's Add-On Drug Xadago

WEDNESDAY, March 22, 2017 (HealthDay News) -- Xadago (safinamide) tablets have been approved by the U.S. Food and Drug Administration as an add-on drug to treat Parkinson's patients who take levodopa or carbidopa but experience "off" episodes.

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Vitamin E, Selenium Don't Prevent Dementia in Older Men

WEDNESDAY, March 22, 2017 (HealthDay News) -- Neither vitamin E, selenium, nor the combination prevents dementia in asymptomatic older men, according to a study published online March 20 in JAMA Neurology.

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TV Ads for Testosterone Tied to Increased Testing, Tx in U.S. Men

WEDNESDAY, March 22, 2017 (HealthDay News) -- Regional exposure to televised direct-to-consumer advertising (DTCA) is associated with an increase in testosterone testing and new initiation, according to a study published in the March 21 issue of the Journal of the American Medical Association.

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Opioid Users Incur Higher Costs After Elective Abdominal Surgery

WEDNESDAY, March 22, 2017 (HealthDay News) -- Preoperative opioid use is associated with increased health care utilization and costs after elective abdominal surgery, according to a study published in the April issue of the Annals of Surgery.

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Multiple Dosing Mitigates ASA Hyporesponsiveness After CABG

WEDNESDAY, March 22, 2017 (HealthDay News) -- Acetylsalicylic acid (ASA) hyporesponsiveness after coronary artery bypass graft (CABG) surgery can be overcome by multiple dosing, according to a study published online March 7 in the Journal of Thrombosis and Haemostasis.

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Prenatal DHA Supplementation Doesn't Increase IQ at Age 7

TUESDAY, March 21, 2017 (HealthDay News) -- Prenatal docosahexaenoic acid (DHA) supplementation does not affect IQ at age 7 years, according to a research letter published in the March 21 issue of the Journal of the American Medical Association.

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Review: Multiple DAA Regimens Effective for HCV Genotype 1

TUESDAY, March 21, 2017 (HealthDay News) -- For hepatitis C virus (HCV) genotype 1 infection, multiple direct-acting antiviral (DAA) regimens show high rates of safety, tolerability, and efficacy, according to a review published online March 21 in the Annals of Internal Medicine.

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Intradiscal Steroid Offers Short-Term Relief of Lower Back Pain

TUESDAY, March 21, 2017 (HealthDay News) -- For patients with chronic low back pain (LBP) with active discopathy, a single glucocorticoid intradiscal injection (GC IDI) is associated with reduced LBP at one month but not 12 months after the intervention, according to a study published online March 21 in the Annals of Internal Medicine.

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ω-3 Essential Fatty Acids May Protect Corneal Nerves in Dry Eye

TUESDAY, March 21, 2017 (HealthDay News) -- Oral, long-chain omega-3 (ω-3) essential fatty acid (EFA) supplementation is neuroprotective to corneal nerves for patients with dry eye disease, according to a study published online March 12 in Ophthalmic & Physiological Optics.

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No Link for Paternal Use of MTX, Adverse Pregnancy Outcomes

TUESDAY, March 21, 2017 (HealthDay News) -- Paternal exposure to methotrexate within 90 days before pregnancy is not associated with congenital malformations, stillbirths, or preterm birth, according to a study published in the April issue of Obstetrics & Gynecology.

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Magnesium Wasting Despite Diuretic Choice in Cervical CA Tx

MONDAY, March 20, 2017 (HealthDay News) -- For women with cervical cancer, administration of cisplatin concomitant with whole pelvic radiation is associated with magnesium wasting, according to a study published online March 9 in the Journal of Clinical Pharmacy and Therapeutics.

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Initial Rx Can Affect Likelihood of Long-Term Opioid Use

FRIDAY, March 17, 2017 (HealthDay News) -- Doctors who limit the supply of opioids they prescribe to three days or less may help patients reduce their risk of dependence and addiction, according to research published in the March 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Glaucoma Surgery Risk Up With 7+ Injections of Bevacizumab

FRIDAY, March 17, 2017 (HealthDay News) -- Seven or more injections of bevacizumab annually is associated with increased risk of glaucoma surgery, according to a study published online March 16 in JAMA Ophthalmology.

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Continuing Statins Up to Surgery May Improve CABG Outcomes

FRIDAY, March 17, 2017 (HealthDay News) -- Coronary artery bypass graft (CABG) surgery patients taking statins may improve their survival odds if the medication is continued up to the day of surgery, according to a study published online March 16 in the Annals of Thoracic Surgery.

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Patients Have High Confidence in Self-Testing INR

FRIDAY, March 17, 2017 (HealthDay News) -- Most patients have high confidence in self-testing their international normalized ratio (INR), according to a study published online Feb. 23 in the Journal of Clinical Nursing.

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ACE Inhibitors, ARBs May Slow Percent Emphysema Progression

FRIDAY, March 17, 2017 (HealthDay News) -- Use of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) is associated with slowed progression of percent emphysema on chest computed tomography (CT), according to a study published online Feb. 16 in the Annals of the American Thoracic Society.

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Supervised Self-Injection Ups Teens' Comfort With Approach

THURSDAY, March 16, 2017 (HealthDay News) -- For food-allergic adolescents at risk for anaphylaxis, supervised self-infection with an empty syringe is associated with improved comfort levels with self-injection, according to a study published in the March-April issue of the Journal of Allergy and Clinical Immunology: In Practice.

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Thiamine May Reduce Progression to Renal Replacement Therapy

THURSDAY, March 16, 2017 (HealthDay News) -- For patients in septic shock, thiamine is associated with a lower rate of progression to renal replacement therapy (RRT), according to research published online Feb. 16 in the Annals of the American Thoracic Society.

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Short Course of Intensive Lifestyle, Drug Tx Helpful in T2DM

THURSDAY, March 16, 2017 (HealthDay News) -- Intensive lifestyle and drug therapy is associated with achievement of normoglycemia and sustained weight loss in patients with type 2 diabetes, according to a study published online March 15 in the Journal of Clinical Endocrinology & Metabolism.

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Clinical Decision Support System Use Tied to Fewer VTE Events

THURSDAY, March 16, 2017 (HealthDay News) -- Use of computerized clinical decision support systems (CCDSSs) among surgical patients is associated with an increase in the rate of appropriate ordering of venous thromboembolism (VTE) prophylaxis and a decrease in the risk of VTE events, according to a review published online March 15 in JAMA Surgery.

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Concurrent Benzodiazepine, Opioid Use Up Significantly

WEDNESDAY, March 15, 2017 (HealthDay News) -- From 2001 to 2013, concurrent benzodiazepine/opioid use significantly increased in privately-insured patients in the United States, according to a report published online March 14 in The BMJ.

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Immune Responses to Ebola Vaccines Persist at One Year

WEDNESDAY, March 15, 2017 (HealthDay News) -- After heterologous primary and booster vaccination schedule of the adenovirus type 26 vector vaccine encoding Ebola virus glycoprotein (Ad26.ZEBOV) and the modified vaccinia virus Ankara vector vaccine, encoding glycoproteins from Ebola, Sudan, Marburg, and Tai Forest viruses nucleoprotein (MVA-BN-Filo) immunity persists for one year, according to a research letter published in the March 14 issue of the Journal of the American Medical Association.

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Economic Benefit for Lifestyle Modification in Prediabetes

WEDNESDAY, March 15, 2017 (HealthDay News) -- For individuals with prediabetes, participation in lifestyle modifications such as the National Diabetes Prevention Program (DPP) is associated with economic benefit, according to a study published online Feb. 13 in Population Health Management.

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Support for Health Law Up to 48 Percent in February

TUESDAY, March 14, 2017 (HealthDay News) -- Support for the health law is increasing, with most Americans feeling that Medicaid should continue as it is today, according to a report published by Kaiser Health News.

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Many A-Fib Patients Not Getting Appropriate Anticoagulation Rx

TUESDAY, March 14, 2017 (HealthDay News) -- Many patients with atrial fibrillation who experience a stroke may not have been on appropriate anticoagulation therapy, according to a study published in the March 14 issue of the Journal of the American Medical Association.

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Antibiotics Ineffective for Mildly Infected Eczema in Children

TUESDAY, March 14, 2017 (HealthDay News) -- Despite widespread use, antibiotics are not an effective treatment for mild clinically infected eczema in children, according to a study published in the March/April issue of the Annals of Family Medicine.

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Omega-3 Supplements May Benefit Heart Failure Patients

TUESDAY, March 14, 2017 (HealthDay News) -- Prescription of omega-3 supplements may benefit some patients with myocardial infarction (MI) and patients with heart failure, according to a new report published online March 13 in Circulation.

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Experimental Nutrient Kit May Avert Postpartum Depression

TUESDAY, March 14, 2017 (HealthDay News) -- Researchers suggest that three days of an experimental dietary supplementation may eliminate depressed mood after childbirth, according to a study published online March 13 in the Proceedings of the National Academy of Sciences.

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ADA Updates Standards of Medical Care in Diabetes

TUESDAY, March 14, 2017 (HealthDay News) -- The American Diabetes Association (ADA) recommends metformin as first-line therapy for type 2 diabetes, according to a synopsis of the 2017 ADA Standards of Medical Care in Diabetes published online March 14 in the Annals of Internal Medicine.

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Rx Improves Nasal Symptoms in Laryngopharyngeal Reflux

TUESDAY, March 14, 2017 (HealthDay News) -- For patients with laryngopharyngeal reflux (LPR), anti-reflux medication is associated with improvement in nasal parameters, according to a study published online March 9 in JAMA Otolaryngology-Head & Neck Surgery.

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Higher Spending by Physicians Not Tied to Better Outcomes

MONDAY, March 13, 2017 (HealthDay News) -- Medicare patients treated by higher-spending physicians are just as likely to be readmitted or die within 30 days of being admitted to the hospital as patients treated by doctors who order fewer or less-expensive tests and treatments, according to a study published online March 13 in JAMA Internal Medicine.

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Post-PCV13 Drop in Streptococcus pneumoniae Bacteremia

MONDAY, March 13, 2017 (HealthDay News) -- Introduction of seven-valent and 13-valent pneumococcal conjugate vaccine (PCV13) correlated with a reduction in Streptococcus pneumoniae bacteremia, according to a review published online March 10 in Pediatrics.

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HBV Reactivation Seen With DAA Treatment of Chronic Hep C

MONDAY, March 13, 2017 (HealthDay News) -- For patients with chronic hepatitis C (CHC) treated with direct-acting antivirals (DAAs), hepatitis B virus (HBV) reactivation may occur in those with current HBV infection, according to a study published online Feb. 23 in the Journal of Gastroenterology and Hepatology.

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Contraceptive Use Up for Women With Congenital Heart Disease

MONDAY, March 13, 2017 (HealthDay News) -- Women with congenital heart disease (CHD) use a spectrum of contraceptive methods, with barrier methods and oral contraception (OC) preferred, according to a study published in the March 15 issue of The American Journal of Cardiology.

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Better Outcomes in T2DM With No Delay in Tx Intensification

FRIDAY, March 10, 2017 (HealthDay News) -- For patients with type 2 diabetes, not delaying intensification of oral antidiabetic drugs (OADs) is associated with greater reductions in hemoglobin A1c (HbA1c), and with reduced risks of cardiovascular events and amputations, according to a study published online Feb. 17 in Diabetes, Obesity and Metabolism.

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Most Doctors Recommend FDA-Approved Drugs Before E-Cigs

FRIDAY, March 10, 2017 (HealthDay News) -- Most primary care physicians and pulmonologists recommend use of U.S. Food and Drug Administration-approved smoking cessation medications before use of electronic cigarettes, according to a letter to the editor published online March 2 in the Annals of the American Thoracic Society.

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Lasting Outcomes for Imatinib in Chronic Myeloid Leukemia

THURSDAY, March 9, 2017 (HealthDay News) -- For patients with newly diagnosed chronic myeloid leukemia (CML), treatment with imatinib is associated with an estimated overall survival rate of 83.3 percent at 10 years, according to a study published in the March 9 issue of the New England Journal of Medicine.

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ACA's Medicaid Expansion May Pose Challenges to Timely Care

THURSDAY, March 9, 2017 (HealthDay News) -- People living in states that expanded Medicaid under the Affordable Care Act (ACA) are less likely to be uninsured or struggling with the strain of unpaid medical bills, but they also seem to have increased difficulty receiving timely care, according to research published in the March 9 issue of the New England Journal of Medicine.

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Nonclinical Factors Drive Antibiotic Choice in Pediatric CAP

THURSDAY, March 9, 2017 (HealthDay News) -- For children with community-acquired pneumonia (CAP), patient and nonclinical characteristics are associated with receipt of macrolides and broad-spectrum antibiotics versus amoxicillin, according to a study published online March 7 in Pediatrics.

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Off-Label Donepezil Rx for MCI Could Be Risky for Some Patients

WEDNESDAY, March 8, 2017 (HealthDay News) -- Donepezil should not be prescribed to patients with mild cognitive impairment without first giving them a genetic test, according to research published recently in the Journal of Alzheimer's Disease.

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Ketamine Beneficial for Certain Patients With Mood Disorders

WEDNESDAY, March 8, 2017 (HealthDay News) -- Use of ketamine for treatment of mood disorders should include appropriate patient selection and consideration of potential risks of treatment, according to a consensus statement published online March 1 in JAMA Psychiatry.

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Vildagliptin, Metformin Have Different Effects on BP in T2DM

WEDNESDAY, March 8, 2017 (HealthDay News) -- For patients with type 2 diabetes, vildagliptin lowers blood pressure (BP) and elevates heart rate (HR), while metformin increases HR with no effect on BP during intraduodenal (ID) glucose infusion, according to a study published online March 3 in Diabetes Care.

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CDC: Arthritis Limits the Activities of 24 Million U.S. Adults

WEDNESDAY, March 8, 2017 (HealthDay News) -- One in four adults in America report an arthritis diagnosis, with the number of individuals disabled by it up 20 percent since 2002, according to a report from the U.S. Centers for Disease Control and Prevention.

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Anakinra Ineffective for Reducing Symptoms of Chronic Fatigue

TUESDAY, March 7, 2017 (HealthDay News) -- The anti-inflammatory biologic drug anakinra (Kineret) does not reduce fatigue severity in women with chronic fatigue syndrome, according to a study published online March 7 in the Annals of Internal Medicine.

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Republicans Introduce Affordable Care Act Replacement

TUESDAY, March 7, 2017 (HealthDay News) -- An initial Republican replacement for the Affordable Care Act was formally introduced in the House of Representatives on Monday.

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Few Patients With Resistant High BP Take Rx As Prescribed

TUESDAY, March 7, 2017 (HealthDay News) -- Only 20 percent of patients with resistant hypertension take all the medicine they're prescribed, according to research published online March 6 in Hypertension.

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Patients Reluctant to Comply With Drug-Only Psychiatric Treatment

TUESDAY, March 7, 2017 (HealthDay News) -- Mental health patients are more likely to reject treatment if it involves only medication, according to a study published online March 6 in Psychotherapy.

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Watchful Waiting Cost-Effective for Pediatric Acute Otitis Media

TUESDAY, March 7, 2017 (HealthDay News) -- Implementation of the American Academy of Pediatrics guidelines of watchful waiting (WW) for acute otitis media (AOM) is cost-effective, according to research published online March 3 in Pediatrics.

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FDA Approves Noctiva Nasal Spray for Nocturnal Polyuria

MONDAY, March 6, 2017 (HealthDay News) -- Noctiva (desmopressin acetate) nasal spray has been approved by the U.S. Food and Drug Administration to treat frequent urination at night due to nocturnal polyuria.

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Metreleptin Doesn't Improve Glycemic Control in T1DM

MONDAY, March 6, 2017 (HealthDay News) -- For patients with suboptimally controlled type 1 diabetes mellitus (T1DM), metreleptin does not improve glycemic control, but is associated with reductions in body weight and daily insulin dose, according to a study published online Feb. 21 in Diabetes Care.

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Blinatumomab Linked to Longer Survival in Adults With ALL

MONDAY, March 6, 2017 (HealthDay News) -- For patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL), the bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive ALL blasts, blinatumomab, is associated with significantly longer survival than chemotherapy, according to a study published in the March 2 issue of the New England Journal of Medicine.

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Cost-Effectiveness Compared for Metastatic Melanoma Treatments

MONDAY, March 6, 2017 (HealthDay News) -- For patients with BRAF wild-type metastatic melanoma, first-line pembrolizumab (PEM) every three weeks followed by second-line ipilumumab (IPI), or first-line nivolumab (NIVO) followed by IPI, are the most cost-effective strategies, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

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Tolerance Develops in NSAID-Induced Urticaria/Angioedema

FRIDAY, March 3, 2017 (HealthDay News) -- Patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA) may develop tolerance to NSAIDs over time, according to a study published online Feb. 22 in Allergy.

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FDA Approves Odactra for House Dust Mite Allergies

FRIDAY, March 3, 2017 (HealthDay News) -- A new treatment for dust mite allergies has been approved by the U.S. Food and Drug Administration.

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Nemolizumab Found to Be Effective in Atopic Dermatitis

FRIDAY, March 3, 2017 (HealthDay News) -- An experimental drug, nemolizumab, may significantly reduce the itching and improve the appearance of moderate-to-severe atopic dermatitis, according to a study published in the March 2 issue of the New England Journal of Medicine.

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CDC: Children Getting Ill From Ingesting Gel Hand Sanitizer

FRIDAY, March 3, 2017 (HealthDay News) -- A rising number of children are becoming ill from ingesting gel hand sanitizer, according to research published in the March 3 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Wide Variation Found for Amount of Melatonin in Supplements

THURSDAY, March 2, 2017 (HealthDay News) -- Many over-the-counter melatonin products are inaccurately labeled, according to a study published in the Feb. 15 issue of the Journal of Clinical Sleep Medicine.

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Overall, 8.8 Percent of U.S. Population Uninsured in 2016

THURSDAY, March 2, 2017 (HealthDay News) -- Overall, 8.8 percent of individuals of all ages were uninsured in the first nine months of 2016, which marked a nonsignificant reduction from 2015, according to a Feb. 14 report from the National Center for Health Statistics.

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Past Prescribing Behavior Predicts Choice of Insomnia Rx

THURSDAY, March 2, 2017 (HealthDay News) -- In treatment of insomnia, historical preference for a certain medication is highly predictive of future prescribing behavior, according to a study published online Feb. 9 in Scientific Reports.

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Reduced Health Care Use for Exenatide Regimens in T2DM

THURSDAY, March 2, 2017 (HealthDay News) -- For patients with type 2 diabetes, treatment with exenatide is associated with reduced health care resource use and costs compared with basal insulin (BI) regimens, according to a study published online Feb. 20 in Diabetes, Obesity and Metabolism.

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Cognitive Outcomes in Children No Better With Levothyroxine Tx

THURSDAY, March 2, 2017 (HealthDay News) -- Treatment for subclinical hypothyroidism or hypothyroxinemia before 20 weeks of gestation is not associated with better cognitive outcomes in children, according to a study published in the March 2 issue of the New England Journal of Medicine.

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Pravastatin Does Not Improve Survival in Small-Cell Lung Cancer

THURSDAY, March 2, 2017 (HealthDay News) -- For patients with small-cell lung cancer (SCLC), addition of pravastatin to standard chemotherapy does not improve survival, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

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FDA Approves Xermelo for Carcinoid Syndrome Diarrhea

WEDNESDAY, March 1, 2017 (HealthDay News) -- Xermelo (telotristat ethyl) tablets have been approved by the U.S. Food and Drug Administration to treat adults with carcinoid syndrome diarrhea.

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Subdural Hematomas Rising Alongside Antithrombotic Use

WEDNESDAY, March 1, 2017 (HealthDay News) -- Antithrombotic drug use is associated with increased risk of subdural hematoma, according to a study published in the Feb. 28 issue of the Journal of the American Medical Association.

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Exposure to Neuraminidase Inhibitors in Utero Not Harmful

WEDNESDAY, March 1, 2017 (HealthDay News) -- Exposure to neuraminidase inhibitors during pregnancy is not associated with adverse neonatal outcomes or congenital malformations, according to a study published online Feb. 28 in The BMJ.

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Complication Rates Often Higher in Youth With T2DM Versus T1DM

WEDNESDAY, March 1, 2017 (HealthDay News) -- Young people with type 2 diabetes are much more likely to show signs of complications from the disease than those who have type 1 diabetes, according to a study published in the Feb. 28 issue of the Journal of the American Medical Association.

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Physician's Briefing
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