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September 2016 Briefing - Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for September 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Platelet Transfusion Has Minimal Effect for Reversing Ticagrelor

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Autologous platelet transfusion 24 or 48 hours after ticagrelor-mediated platelet inhibition has minimal effect, while a small reversing effect is seen for transfusion after clopidogrel, according to a study published online Sept. 22 in the Journal of Thrombosis and Haemostasis.

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CDC: Too Many Health Care Workers Not Getting Flu Vaccine

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Roughly one in every five American health care workers do not receive the annual influenza vaccination, and in some facilities that number exceeds half, according to research published in the Sept. 30 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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CDC Concerned About Falling Flu Vaccination Rates

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Influenza vaccination coverage declined 1.5 percent across the entire U.S. population during the 2015-2016 flu season, with only 46 percent of Americans receiving the annual vaccine, the U.S. Centers for Disease Control and Prevention announced Thursday.

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Continuous Glucose Monitors Recommended in T1DM

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Continuous glucose monitors are recommended for adults with type 1 diabetes, according to guidelines published online Sept. 2 in the Journal of Clinical Endocrinology and Metabolism.

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One in Five With Non-Valvular A-Fib Receiving Digoxin

FRIDAY, Sept. 30, 2016 (HealthDay News) -- About one in five patients with non-valvular atrial fibrillation (NVAF) receives digoxin, with the indication for use considered inappropriate in nearly 60 percent, according to a study published online Sept. 27 in the Journal of Clinical Pharmacy and Therapeutics.

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Rapid, Successful Response to ART for Many Patients With HIV

FRIDAY, Sept. 30, 2016 (HealthDay News) -- Many HIV-infected patients have rapid and successful immune and virological response to antiretroviral therapy (ART), according to a study published online Sept. 27 in the Journal of Clinical Pharmacy and Therapeutics.

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Adjunctive Azithromycin Beneficial in C-Section Patients

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Adding azithromycin to standard antibiotic therapy before a cesarean section reduces infection rates by 50 percent, according to a study published in the Sept. 29 issue of the New England Journal of Medicine.

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Prescribed NSAIDs Tied to Higher Heart Failure Risk

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Use of prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) may be tied to a higher risk of heart failure, according to research published online Sept. 28 in The BMJ.

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More Evidence HPV Vaccine Protects Against Cervical Cancer

THURSDAY, Sept. 29, 2016 (HealthDay News) -- The vaccine against human papillomavirus (HPV) infection appears even more effective than previously believed, according to a report published online Sept. 29 in JAMA Oncology.

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FDA Approves 'Artificial Pancreas' for Type 1 Diabetes

THURSDAY, Sept. 29, 2016 (HealthDay News) -- The first automated insulin delivery device for type 1 diabetes has been approved by the U.S. Food and Drug Administration for patients aged 14 and older.

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Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Cannabis use may raise the risk of psychosis relapse, according to a study published online Sept. 28 in JAMA Psychiatry.

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Hormonal Contraception May Raise Depression Risk

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Women who use hormonal methods for birth control may have a higher risk of developing depression -- and teenagers may be most vulnerable, according to a study published online Sept. 28 in JAMA Psychiatry.

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Constitutional Symptoms Often Trigger Antibiotic Rx in Elderly

THURSDAY, Sept. 29, 2016 (HealthDay News) -- Constitutional symptoms, including mentation, often lead to diagnostic testing and potentially inappropriate antibiotic prescribing in older patients suspected of having a urinary tract infection (UTI) or pneumonia, according to a study published online Sept. 22 in the Journal of the American Geriatrics Society.

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Capping Copays Will Raise Premiums, Up Drug Prices

THURSDAY, Sept. 29, 2016 (HealthDay News) -- The proposed capping of copays will raise premiums and is likely to increase drug prices, according to a report from the National Center for Policy Analysis (NCPA).

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Long-Term Tx Adherence Low in Mild-to-Moderate Psoriasis

WEDNESDAY, Sept. 28, 2016 (HealthDay News) -- For patients with mild-to-moderate psoriasis, adherence to topical treatment is low, but an internet-based reporting intervention can improve adherence, according to a study published online Sept. 24 in the British Journal of Dermatology.

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Changes in Use of Glucose-Lowering Drugs From 2006-2013

WEDNESDAY, Sept. 28, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), the use of glucose-lowering drugs changed from 2006 to 2013, but glycemic control has not changed, according to a study published online Sept. 22 in Diabetes Care.

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Long-Acting Reversible Contraception Highly Acceptable

WEDNESDAY, Sept. 28, 2016 (HealthDay News) -- Long-acting reversible contraception (LARC) is highly acceptable even among women who present to initiate short-acting reversible contraception (SARC), according to a study published online Sept. 19 in the American Journal of Obstetrics & Gynecology.

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Review: 5-HT3 Receptor Antagonists Cut Peri-Op Shivering

TUESDAY, Sept. 27, 2016 (HealthDay News) -- 5-HT3 receptor antagonists (5-HT3RAs) seem to be effective for preventing perioperative shivering (POS), according to a review and meta-analysis published online Sept. 15 in the Journal of Clinical Pharmacology.

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Both Statin, Non-Statin Therapies Effective for Lowering LDL

TUESDAY, Sept. 27, 2016 (HealthDay News) -- Treatments other than statins also can effectively reduce cardiovascular risk, according to a review and meta-analysis published in the Sept. 27 issue of the Journal of the American Medical Association.

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Gliptin Treatment Tied to Higher Risk of Acute Pancreatitis

TUESDAY, Sept. 27, 2016 (HealthDay News) -- Gliptin treatment is associated with increased acute pancreatitis risk, according to research published online Sept. 22 in Diabetes Care.

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Achieving Optimal Medical Tx Before PCI Beneficial in CAD

TUESDAY, Sept. 27, 2016 (HealthDay News) -- In patients with coronary artery disease (CAD), achievement of optimal medical therapy (OMT) before implantation of a drug-eluting stent significantly reduces subsequent cardiac events, according to a study published in the Sept. 15 issue of The American Journal of Cardiology.

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Cancer Patients Have Unrealistic Hopes Entering Clinical Trials

MONDAY, Sept. 26, 2016 (HealthDay News) -- Many cancer patients hold unrealistic hopes when they decide to join early-stage clinical trials of experimental treatments, according to research published online Sept. 26 in Cancer.

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European, American Guidelines Lead to Different Recs for Statins

MONDAY, Sept. 26, 2016 (HealthDay News) -- European and American guidelines lead to different recommendations for statin therapy, according to a study published online Sept. 21 in JACC: Cardiovascular Imaging.

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Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

MONDAY, Sept. 26, 2016 (HealthDay News) -- For patients with inadequately controlled, basal insulin-treated type 2 diabetes, a novel, titratable, fixed-ratio combination of insulin glargine (iGlar) and lixisenatide (iGlarLixi) is associated with improvements in glycemic control and reduced body weight, according to a study published online Sept. 20 in Diabetes Care.

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9-cis Retinoic Acid Promising for Lymphedema Prevention

MONDAY, Sept. 26, 2016 (HealthDay News) -- Treatment with 9-cis retinoic acid (RA) has potential as a preventative agent for postsurgical lymphedema, according to an experimental study published in the August issue of the Annals of Surgery.

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Standard and Double Dose Pantoprazole Equally Effective

FRIDAY, Sept. 23, 2016 (HealthDay News) -- For patients with gastric adenoma or early gastric cancer, standard dose or double dose intravenous pantoprazole for 48 hours is equally effective for prevention of delayed bleeding after endoscopic resection, according to a study published online Sept. 16 in the Journal of Gastroenterology and Hepatology.

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Pregabalin Benefits Not Linked to Prior Gabapentin Use

FRIDAY, Sept. 23, 2016 (HealthDay News) -- Pregabalin is beneficial for neuropathic pain, regardless of previous gabapentin use, according to research published online Sept. 9 in Pain Practice.

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Effectiveness of Tobacco Taxation Is Being Undermined

THURSDAY, Sept. 22, 2016 (HealthDay News) -- The effectiveness of tobacco taxation is being undermined by smokers' behavioral changes and tobacco industry promotions, according to a health policy brief published online Sept. 19 in Health Affairs.

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Animal Study Finds DNA-Based Vaccine Effective Against Zika

THURSDAY, Sept. 22, 2016 (HealthDay News) -- An experimental DNA-based vaccine for Zika virus has proceeded to human safety trials, according to findings published online Sept. 22 in Science.

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Tofacitinib Citrate May Stimulate Hair Regrowth in Alopecia Areata

THURSDAY, Sept. 22, 2016 (HealthDay News) -- A drug used for rheumatoid arthritis might regrow hair in alopecia areata (AA) patients, according to a study published online Sept. 22 in JCI Insight.

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Laquinimod Appears Effective Against Multiple Sclerosis

THURSDAY, Sept. 22, 2016 (HealthDay News) -- An experimental drug, laquinimod, appears to prevent or slow the progression of multiple sclerosis (MS) in mice, according to a study published online Sept. 21 in Neurology: Neuroimmunology & Neuroinflammation.

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Immunotherapy Promising for Tx of Acute Myeloid Leukemia

THURSDAY, Sept. 22, 2016 (HealthDay News) -- A new type of immunotherapy involving natural killer (NK) cells may help treat acute myeloid leukemia (AML) patients, according to a study published in the Sept. 21 issue of Science Translational Medicine.

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KAF156 Active for Adults With Vivax, Falciparum Malaria

THURSDAY, Sept. 22, 2016 (HealthDay News) -- For adults with acute Plasmodium vivax or P. falciparum, KAF156 shows antimalarial activity, according to a study published in the Sept. 22 issue of the New England Journal of Medicine.

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Economic Burden of U.S. Opioid Epidemic $78.5 Billion Annually

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Abuse of opioids costs the U.S. economy $78.5 billion a year, according to a study published in the October issue of Medical Care.

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Non-TNF Biologic Beats Second Anti-TNF in Rheumatoid Arthritis

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- A non-tumor necrosis factor (TNF)-targeted biologic is more effective than a second anti-TNF drug for treatment of rheumatoid arthritis in patients with insufficient response to a first anti-TNF drug, according to a study published in the Sept. 20 issue of the Journal of the American Medical Association.

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Physicians Treating Few Patients With Buprenorphine

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- For buprenorphine prescribers, the monthly patient census is 13 patients, according to a research letter published in the Sept. 20 issue of the Journal of the American Medical Association.

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Multigrowth Factor Cream Speeds Recovery After Laser Therapy

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Treatment with a multigrowth factor (MGF)-containing cream is associated with more rapid recovery after laser ablation, according to a study published online Sept. 16 in the Journal of Cosmetic Dermatology.

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NIH: More Must Be Done to Fight Antimicrobial Resistance

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- Antimicrobial resistance (AMR) remains a major public health threat, and only a multipronged attack can address the problem, according to a report published in the Sept. 20 issue of the Journal of the American Medical Association.

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AACR: More Cancer Patients Benefiting From Immunotherapy

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- More Americans are benefiting from immunotherapy, according to the sixth annual American Association for Cancer Research (AACR) Cancer Progress Report.

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H1N1 Vaccine Not Associated With Congenital Malformations

TUESDAY, Sept. 20, 2016 (HealthDay News) -- The vaccine against the H1N1 strain of influenza doesn't appear to be linked to congenital malformations, according to research published online Sept. 20 in the Annals of Internal Medicine.

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Diabetes Risk Higher in Canada's First Nations People

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Diabetes is more widespread among descendants of Canada's First Nations people than among the general population, according to a study published online Sept. 19 in CMAJ, the journal of the Canadian Medical Association.

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CDC: Prescribing of Antibiotics in U.S. Hospitals Still Too High

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Despite growing concerns about creating drug-resistant bacteria, overprescribing of antibiotics in U.S. hospitals didn't drop between 2006 and 2012, according to a new federal report published online Sept. 19 in JAMA Internal Medicine.

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Hospitals Increasingly Employing Doctors, Effects on Care Uncertain

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Hospitals are increasingly switching to an employment relationship with physicians, but switching has had no impact on primary composite quality metrics, according to a study published online Sept. 20 in the Annals of Internal Medicine.

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Misoprostol Doesn't Cut Risk of Postpartum Hemorrhage

TUESDAY, Sept. 20, 2016 (HealthDay News) -- For women in the third stage of labor, misoprostol administered with routine oxytocin does not reduce the rate of postpartum hemorrhage, according to a study published online Sept. 5 in Obstetrics & Gynecology.

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Gemigliptin, Metformin Combo Beats Monotherapy in T2DM

TUESDAY, Sept. 20, 2016 (HealthDay News) -- Gemigliptin combined with metformin is superior to monotherapy with either drug for patients with type 2 diabetes mellitus (T2DM), according to a study published online Sept. 13 in Diabetes, Obesity and Metabolism.

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FDA Approves First Drug for Duchenne Muscular Dystrophy

MONDAY, Sept. 19, 2016 (HealthDay News) -- Exondys 51 (eteplirsen) injection has been approved by the U.S. Food and Drug Administration for certain patients with Duchenne muscular dystrophy (DMD). It is the first drug to gain FDA approval for the condition.

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AAP Says Codeine Not Safe for Children, Urges Restrictions

MONDAY, Sept. 19, 2016 (HealthDay News) -- Codeine is unsafe for children and should no longer be given to them, according to a new report from the American Academy of Pediatrics (AAP) published online Sept. 19 in Pediatrics.

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Adding Rituximab to Chemo Ups Event-Free Survival in ALL

MONDAY, Sept. 19, 2016 (HealthDay News) -- For young adults with acute lymphoblastic leukemia (ALL), adding rituximab to chemotherapy is associated with increased event-free survival, according to a study published in the Sept. 15 issue of the New England Journal of Medicine.

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Most Patients Prefer Oral Dual Therapy in Chronic Hepatitis C

MONDAY, Sept. 19, 2016 (HealthDay News) -- For patients with chronic hepatitis C (CHC), most prefer oral therapy with sofosbuvir (SOF) and ribavirin (RBV) versus triple therapy involving pegylated interferon (PegIFN), according to a study published online Sept. 14 in the Journal of Gastroenterology and Hepatology.

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Average Premiums for Health Care Coverage Stable in 2016

MONDAY, Sept. 19, 2016 (HealthDay News) -- The average annual premiums for single and family coverage remained stable in 2016, according to a study published online Sept. 14 in Health Affairs.

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Tighter Systolic BP Control Could Save 100K U.S. Lives Annually

FRIDAY, Sept. 16, 2016 (HealthDay News) -- Engaging Americans at high risk for cardiovascular disease in aggressive efforts to lower their systolic blood pressure could save more than 100,000 lives a year, according to a study presented at the American Heart Association's Council on Hypertension 2016 Scientific Sessions, held from Sept. 14 to 17 in Orlando, Fla.

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Evolocumab Safe, Effective for Those With Dysglycemia, MetS

FRIDAY, Sept. 16, 2016 (HealthDay News) -- For patients with or without dysglycemia or metabolic syndrome (MetS), evolocumab is safe and efficacious for reducing low-density lipoprotein cholesterol at 52 weeks, according to research published online Sept. 13 in Diabetes, Obesity and Metabolism.

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Recommending Oral Probiotics Doesn't Cut Antibiotic Use

FRIDAY, Sept. 16, 2016 (HealthDay News) -- Advising patients with asthma to take probiotics does not reduce antibiotic use, according to a study published in the September/October issue of the Annals of Family Medicine.

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Nifedipine Not Superior to Placebo for Chronic Chilblains

FRIDAY, Sept. 16, 2016 (HealthDay News) -- For patients with chronic chilblains, nifedipine is not superior to placebo, according to a study published in the September/October issue of the Annals of Family Medicine.

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Testosterone Seems Safe for Hypogonadal Prostate CA Patients

FRIDAY, Sept. 16, 2016 (HealthDay News) -- For hypogonadal men with prostate cancer, testosterone treatment seems oncologically safe, according to a study published in the October issue of The Journal of Urology.

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Anticoagulation Cuts TEC Rate in Adults After Fontan Surgery

FRIDAY, Sept. 16, 2016 (HealthDay News) -- For adults with atrial arrhythmia after Fontan operation, the risk of thrombotic and embolic complications (TEC) is reduced with anticoagulation therapy, according to research published in the Sept. 20 issue of the Journal of the American College of Cardiology.

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Early Rx With Losartan Doesn't Slow Kidney Disease Progression

FRIDAY, Sept. 16, 2016 (HealthDay News) -- For American-Indians with type 2 diabetes, early administration of losartan does not slow progression of glomerular filtration rate (GFR) decline, according to a study published online Sept. 9 in Diabetes Care.

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Learning Collaborative Model Cuts Door-to-Needle Times

THURSDAY, Sept. 15, 2016 (HealthDay News) -- A learning collaborative model can reduce door-to-needle (DTN) times in patients with acute ischemic stroke treated with tissue-type plasminogen activator, according to a study published online Sept. 13 in Circulation: Cardiovascular Quality and Outcomes.

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Lower Citrulline Values With Metformin Treatment in T2DM

THURSDAY, Sept. 15, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), metformin treatment is associated with lower citrulline values, according to a study published online Sept. 12 in Diabetes.

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Recommendations Developed for Cost-Effectiveness Analyses

THURSDAY, Sept. 15, 2016 (HealthDay News) -- A new set of recommendations has been developed for conduct and reporting of cost-effectiveness analyses, according to a report published in the Sept. 13 issue of the Journal of the American Medical Association.

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Importance of Drug As Assessed by Doctor Not Tied to Adherence

THURSDAY, Sept. 15, 2016 (HealthDay News) -- Physician-assessed drug importance is not associated with patient-reported drug adherence, according to a study published in the September/October issue of the Annals of Family Medicine.

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Experimental Gel Antibiotic May Offer New Otitis Media Rx

THURSDAY, Sept. 15, 2016 (HealthDay News) -- A single application of an antibiotic gel into the ear might one day offer an easier way to treat bacterial otitis media, according to an experimental study published online Sept. 14 in Science Translational Medicine.

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Experimental Zoster Vaccine Effective in Adults Aged 70+

THURSDAY, Sept. 15, 2016 (HealthDay News) -- An experimental vaccine against herpes zoster may offer lasting protection for most older adults who receive it, according to a study published in the Sept. 15 issue of the New England Journal of Medicine.

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Sertraline May Help Prevent Depressive Disorders After TBI

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- Sertraline seems to be efficacious for preventing depressive disorders after traumatic brain injury (TBI), according to a study published online Sept. 14 in JAMA Psychiatry.

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Many Medicare Patients Non-Adherent to Antihypertensives

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- Nearly five million Medicare prescription drug enrollees aren't taking their antihypertensive medication as directed, according to research published in the Sept. 13 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Pain and Itch Highly Prevalent Months After Herpes Zoster

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- For patients with herpes zoster (HZ), pain and itch are prevalent and pain is associated with quality of life and increased costs, according to a study published online Sept. 9 in Pain Practice.

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Sitagliptin Not Linked to Higher Fracture Risk in Diabetes

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- Patients with diabetes often have fractures, but sitagliptin is not associated with increased fracture risk, according to a study published online Sept. 8 in Diabetes, Obesity and Metabolism.

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Meta-Analysis: Colchicine Cuts Risk of Pericarditis Recurrence

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- Colchicine is effective and reduces the risk of pericarditis recurrence/post-pericardiotomy syndrome, according to a meta-analysis published online Aug. 31 in Cardiovascular Therapeutics.

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Most Patients Taking Opioids Open to Receiving Naloxone Rx

TUESDAY, Sept. 13, 2016 (HealthDay News) -- A new, small survey of patients taking opioids found that most were willing to also fill prescriptions for naloxone. The report was published in the September/October issue of the Annals of Family Medicine.

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U-Shaped Link for Fish Consumption, Mortality

TUESDAY, Sept. 13, 2016 (HealthDay News) -- There is a U-shaped correlation between fish consumption and all-cause mortality, according to a study published online Sept. 7 in the Journal of Internal Medicine.

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New Anticancer Drugs Up Costs and Life Expectancy Considerably

TUESDAY, Sept. 13, 2016 (HealthDay News) -- New anticancer drugs, which increase costs considerably, are associated with large gains in life expectancy, according to research published in the September issue of Health Affairs.

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Too Few Diabetes Patients Receiving Statins

TUESDAY, Sept. 13, 2016 (HealthDay News) -- Nearly all middle-aged patients with diabetes should be taking statins, but cardiologists fail to prescribe these medications for two out of every five such patients in their care, according to a study published in the Sept. 20 issue of the Journal of the American College of Cardiology.

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Parents Often Make Dosing Errors With Liquid Medications

MONDAY, Sept. 12, 2016 (HealthDay News) -- During laboratory experiments, four out of five parents made at least one dosing error when using either a dosing cup or an oral syringe, according to a study published online Sept. 12 in Pediatrics.

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Review of Evidence Confirms Efficacy of Statin Therapy

MONDAY, Sept. 12, 2016 (HealthDay News) -- Statins are efficacious and safe for reducing the risk of vascular events, according to a review published online Sept. 8 in The Lancet.

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Corticosteroids Linked to Worse Outcome in Facial Palsy

MONDAY, Sept. 12, 2016 (HealthDay News) -- For patients with Lyme disease-associated facial palsy (LDFP), corticosteroid use is associated with worse long-term facial function outcome, according to a study published online Sept. 6 in The Laryngoscope.

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Levonorgestrel IUD Potentially Cost-Effective in Obese Women

MONDAY, Sept. 12, 2016 (HealthDay News) -- For obese women, the levonorgestrel intrauterine device (IUD) could be cost-effective for preventing endometrial cancer deaths, according to a study published in the October issue of Obstetrics & Gynecology.

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Neoadjuvant Chemotherapy Use Up in Ovarian Cancer Treatment

MONDAY, Sept. 12, 2016 (HealthDay News) -- For patients with stage IIIC to IV ovarian cancer, neoadjuvant chemotherapy (NACT) use increased from 2003 to 2012, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

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Study Compares Effectiveness of Biologics in Psoriasis Treatment

MONDAY, Sept. 12, 2016 (HealthDay News) -- For patients with psoriasis, ustekinumab has the highest effectiveness over five years of treatment and adalimumab and ustekinumab more often reach a 75 percent reduction in Psoriasis Area Severity Index (PASI) compared to baseline (PASI75) than etanercept, according to a study published online Aug. 31 in the British Journal of Dermatology.

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Reports of Fatal Anaphylaxis With IV Iron Products

MONDAY, Sept. 12, 2016 (HealthDay News) -- Fatal anaphylaxis cases have been reported with administration of intravenous (IV) iron products, according to a letter to the editor published online Aug. 29 in the American Journal of Hematology.

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Statin Rx May Prevent Myocardial Ischemia-Reperfusion Injury

MONDAY, Sept. 12, 2016 (HealthDay News) -- Postconditioning with rosuvastatin prevents myocardial ischemia-reperfusion injury in a rat model, according to a study published online Aug. 31 in Cardiovascular Therapeutics.

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Probable PTSD Linked to Bronchodilator Response, Asthma

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Probable posttraumatic stress disorder (PTSD) is associated with bronchodilator response (BDR) and incident asthma, according to a study published online Aug. 22 in the American Journal of Respiratory and Critical care Medicine.

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OTC Head Lice Treatments Are Losing Effectiveness

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Over-the-counter products have lost much of their effectiveness against head lice, according to research published in the September/October issue of Pediatric Dermatology.

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Experimental Drug Shows Promise in Melanoma

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Pevonedistat, a specific inhibitor of the NEDD8 activating enzyme, inhibits the activity of cullin E3 ligases, inhibiting cancer cells in vitro, according to a study published in the August issue of EBioMedicine.

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Liraglutide, Sitagliptin Have No Effect on Renal Hemodynamics

FRIDAY, Sept. 9, 2016 (HealthDay News) -- In insulin-naive patients with type 2 diabetes, 12 weeks of treatment with liraglutide or sitagliptin has no effect on renal hemodynamics, according to a study published online Sept. 1 in Diabetes Care.

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Losartan Reduces Aldosterone in Patients With HTN, Without OSA

FRIDAY, Sept. 9, 2016 (HealthDay News) -- For patients with hypertension and obstructive sleep apnea (OSA), treatment with losartan does not lead to significant reductions in aldosterone, but the treatment is tied to aldosterone reductions in patients with hypertension but without OSA, according to a study published online Aug. 22 in the Annals of the American Thoracic Society.

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Pregabalin Significantly Improves Neuropathic Pain

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Pregabalin significantly improves neuropathic pain, irrespective of the time since pain onset, according to a study published online Sept. 2 in Pain Practice.

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Dexrazoxane Prevents Chemo-Induced Cardiotoxicity

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Dexrazoxane can prevent anthracycline-induced cardiotoxicity and should be used for cardioprotection in children and young adults, according to a review published online Sept. 4 in the British Journal of Clinical Pharmacology.

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Remission Up With T Cell Therapy for Non-Hodgkin's Lymphoma

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Immunotherapy with CD19 chimeric antigen receptor (CAR)-modified T cells in a defined CD4+/CD8+ ratio can lead to improved disease response and overall and progression-free survival, according to a study published in the Sept. 7 issue of Science Translational Medicine.

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Intensive T2DM Tx Extends Complication-Free Survival

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Early, intensified intervention in type 2 diabetes patients with microalbuminuria increases life span, with patients more likely free from severe complications, according to a study published online Aug. 16 in Diabetologia.

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Adalimumab Found to Be Effective for Noninfectious Uveitis

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Patients with noninfectious uveitis may benefit from adalimumab (Humira), according to a study published in the Sept. 8 issue of the New England Journal of Medicine.

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Limited Dialyzability for Oxycodone, Noroxycodone

THURSDAY, Sept. 8, 2016 (HealthDay News) -- For patients with chronic pain with end-stage renal disease, oxycodone and noroxycodone have limited dialyzability, according to a study published online Sept. 2 in Pain Practice.

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A-Fib Contributes to Wide Range of Other Health Conditions

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Atrial fibrillation is associated with a wider range of conditions than previously believed, according to a review and meta-analysis published online Sept. 6 in The BMJ.

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Oral Contraceptives May Be Cause of Drop in Ovarian CA Mortality

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Ovarian cancer mortality is down dramatically in many parts of the world, and the use of oral contraceptives (OCs) may be a main reason why, according to a study published online Sept. 5 in the Annals of Oncology.

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Saline-Based Nasal Spray Found to Be Effective for Epistaxis

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- A simple saline-based nasal spray is as effective as medicated sprays in controlling epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT), according to a study published in the Sept. 6 issue of the Journal of the American Medical Association.

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Canadian Cardiovascular Society Updates A-Fib Guidelines

TUESDAY, Sept. 6, 2016 (HealthDay News) -- The Canadian Cardiovascular Society has updated guidelines relating to the management of atrial fibrillation (AF); the guidelines were published online Sept. 5 in the Canadian Journal of Cardiology.

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Metformin Tied to Cardiovascular Benefits in T1DM Patients

TUESDAY, Sept. 6, 2016 (HealthDay News) -- Metformin may help preserve cardiovascular health in patients with type 1 diabetes, according to a study published online Aug. 26 in Cardiovascular Diabetology.

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AAP Releases Updated Guidance for Flu Vaccination in Children

TUESDAY, Sept. 6, 2016 (HealthDay News) -- All children aged 6 months and older should receive a seasonal flu vaccine during the 2016-2017 flu season, according to an updated policy statement from the American Academy of Pediatrics (AAP), published online Sept. 6 in Pediatrics.

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Fluticasone Furoate/Vilanterol Cuts Exacerbations in COPD

TUESDAY, Sept. 6, 2016 (HealthDay News) -- A combination of fluticasone furoate and vilanterol reduces the rate of moderate or severe exacerbations among patients with chronic obstructive pulmonary disease (COPD), according to a study published online Sept. 4 in the New England Journal of Medicine. The research was published to coincide with the annual European Respiratory Society International Congress, held from Sept. 3 to 7 in London.

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Warfarin Persistence Higher Than Previously Reported in A-Fib

TUESDAY, Sept. 6, 2016 (HealthDay News) -- Among patients with atrial fibrillation (AF), the proportion of warfarin persistence is 0.91 at one year and 0.73 at four years, according to a study published online Aug. 27 in Cardiovascular Therapeutics.

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Antidiabetes Prescriptions 15-Fold Higher Than Antiobesity Rx

TUESDAY, Sept. 6, 2016 (HealthDay News) -- The adoption rate of the newest antidiabetes pharmacotherapy, subtype 2 sodium-glucose transport protein inhibitors (SGLT2s), is considerably higher than that of antiobesity pharmacotherapies, according to research published online Aug. 29 in Obesity.

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Older Adults Employ High-Risk Methods to Obtain Opioids

TUESDAY, Sept. 6, 2016 (HealthDay News) -- About 15 percent of older adults use high-risk methods for obtaining prescription opioids, according to a study published online Aug. 26 in the Journal of the American Geriatrics Society.

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New Decision-Making Tool Can Cut Unnecessary Antibiotic Use

FRIDAY, Sept. 2, 2016 (HealthDay News) -- A new decision-making tool for doctors may help reduce unnecessary use of antibiotics in children with respiratory tract infection and cough, according to research published online Sept. 1 in The Lancet Respiratory Medicine.

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Smokers More Prone to Relapse After Crohn's Surgery

FRIDAY, Sept. 2, 2016 (HealthDay News) -- Smoking increases the risk that Crohn's disease patients will experience clinical recurrence after bowel surgery, according to research published online Aug. 30 in The Lancet Gastroenterology and Hepatology.

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Infective Endocarditis From Injection Drug Use Increasing

FRIDAY, Sept. 2, 2016 (HealthDay News) -- The number of Americans hospitalized with infective endocarditis (IE) related to injecting opioids and heroin is on the rise, according to a study published in the Summer issue of Open Forum Infectious Diseases.

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Rise in Endogenous Klebsiella pneumoniae Endophthalmitis

FRIDAY, Sept. 2, 2016 (HealthDay News) -- Increasing trends of endogenous Klebsiella pneumoniae endophthalmitis (EKPE) have been reported in Australia, according to research published online Aug. 26 in Clinical & Experimental Ophthalmology.

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Non-Drug Methods Effective for Treating Some Pain Conditions

FRIDAY, Sept. 2, 2016 (HealthDay News) -- Non-drug methods of managing pain from conditions such as headaches and arthritis appear to be effective, according to a review published in the September issue of the Mayo Clinic Proceedings.

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Metformin, Sitagliptin Prolong Normoglycemia Remission in DKA

FRIDAY, Sept. 2, 2016 (HealthDay News) -- For patients with new-onset diabetic ketoacidosis (DKA) and severe hyperglycemia, metformin and sitagliptin treatment after normoglycemia remission correlate with increased relapse-free survival and prolonged remission, according to a study published online Aug. 29 in Diabetes Care.

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Levetiracetam, Topiramate May Be Safer During Pregnancy

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Levetiracetam or topiramate use during pregnancy doesn't appear to harm the child's future cognitive abilities, according to a study published online Aug. 31 in Neurology.

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Δ9-Tetrahydrocannabivarin Beneficial in Type 2 Diabetes

THURSDAY, Sept. 1, 2016 (HealthDay News) -- For patients with non-insulin-treated type 2 diabetes, Δ9-tetrahydrocannabivarin (THCV) reduces fasting plasma glucose, and improves pancreatic β-cell function, adiponectin, and apolipoprotein A, according to a study published online Aug. 29 in Diabetes Care.

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Comorbidity Factors Identified for Exacerbation-Prone Asthma

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Factors that are associated with exacerbation-prone asthma (EPA) have been identified, with blood eosinophils, body mass index, and bronchodilator responsiveness associated with exacerbation frequency, according to a study published online Aug. 24 in the American Journal of Respiratory and Critical Care Medicine.

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Dapagliflozin Improves Insulin Sensitivity in Type 2 Diabetes

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Dapagliflozin improves insulin sensitivity and increases lipid oxidation and plasma ketone concentration in patients with type 2 diabetes mellitus (T2DM), according to a study published online Aug. 25 in Diabetes Care.

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Folic Acid-Fortified Food Tied to Drop in Congenital Heart Defects

THURSDAY, Sept. 1, 2016 (HealthDay News) -- The introduction of folic acid-fortified foods in Canada was associated with a decrease in infants being born with congenital heart defects (CHDs), according to a study published in the Aug. 30 issue of Circulation.

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Hypoglycemia, Bradycardia Up in Neonates Exposed to β-Blockers

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Neonates born to mothers exposed to β-blockers at the time of delivery have increased risk of neonatal hypoglycemia and bradycardia, according to a study published in online Aug. 30 in Pediatrics.

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