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Many Still Prescribe Concomitant (Es)omeprazole, Clopidogrel

Patients on clopidogrel prescribed omeprazole or esomeprazole despite safety warnings

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MONDAY, Aug. 8, 2016 (HealthDay News) -- Advice of regulatory authorities released in 2009 and 2010 regarding safety concerns for concomitant use of clopidogrel and certain proton pump inhibitors (PPIs) was partially followed, according to a study published in the August issue of Pharmacology Research & Perspectives.

Willemien J. Kruik-Kollöffel, Pharm.D., from Medisch Spectrum Twente in Enschede, Netherlands, and colleagues examined the correlation between safety statements and prescription behavior for gastroprotective drugs in naive patients in the Netherlands during 2008 to 2011. Data were analyzed from the PHARMO Database Network to estimate the impact of each communication on drug prescriptions.

The researchers found that 15.5 percent more patients started concomitant use of clopidogrel with esomeprazole or omeprazole and 13.8 percent less with other PPIs after the early communication in January 2009. After the first statement in June 2009 there was a sharp increase in histamine 2-receptor antagonist prescribing, which peaked at 25 percent; after a few months the effect faded. There was a decrease of 11.9 percent for (es)omeprazole and an increase of 16.0 percent for other PPIs when the official advice was to avoid (es)omeprazole in February 2010. However, 22.6 percent of patients started on (es)omeprazole in February 2010.

"Advices of regulatory authorities were followed; however, reluctantly and not fully, probably partly because of the existing scientific doubt about the interaction," the authors write.

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