See What HealthDay Can Do For You
Contact Us

Propranolol Prevents Cocaine-Associated Memory Retrieval

Rat study shows propranolol provides robust, long-lasting memory retrieval deficit

MONDAY, July 25 (HealthDay News) -- The common β-blocker propranolol has been shown to prevent retrieval of cocaine-associated memories in addiction-models in rats, according to an experimental study published in the August issue of Neuropsychopharmacology.

James M. Otis, O.D., and Devin Mueller, Ph.D., from the University of Wisconsin-Milwaukee, investigated the role of β-adrenergic receptor activation in the retrieval of cocaine-associated memory. Using a conditioned place preference (CPP), rats were conditioned to associate one chamber with cocaine, but not another.

The investigators found that the retrieval of a cocaine-associated CPP was prevented when propranolol, but not saline, was administered before a CPP trial. The retrieval deficit was strong and long lasting, with no re-emergence of CPP during a test for spontaneous recovery after 14 days, and there was no recurrence after a priming injection of cocaine. Retrieval was not affected by the peripheral β -adrenergic receptor agonist sotalol.

"Our findings support the use of propranolol, a commonly prescribed β-blocker, as an adjunct to exposure therapy for the treatment of addiction by preventing retrieval of drug-associated memories during and long after treatment, and by providing protection against relapse," the authors write.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.