See What HealthDay Can Do For You
Contact Us

CRP-Guided Testing Cuts Antibiotic Use in COPD Exacerbations

Lower percentage of patients reported antibiotic use, received antibiotic prescriptions

prescription

FRIDAY, July 12, 2019 (HealthDay News) -- For patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD), point-of-care testing of C-reactive protein (CRP) to guide antibiotic prescribing can reduce antibiotic use, according to a study published in the July 11 issue of the New England Journal of Medicine.

Christopher C. Butler, from the University of Oxford in the United Kingdom, and colleagues conducted a randomized trial among 653 patients with COPD who consulted a clinician for an acute exacerbation of COPD. Participants were randomly assigned to receive either usual care guided by CRP point-of-care testing (CRP-guided group) or usual care alone (usual care group).

The researchers found that compared with the usual care group, fewer patients in the CPR-guided group reported antibiotic use (57.0 versus 77.4 percent; adjusted odds ratio, 0.31). At two weeks, the adjusted mean difference in the total score on the Clinical COPD Questionnaire was −0.19 points in favor of the CRP-guided group. A significantly lower percentage of patients in the CRP-guided group received an antibiotic prescription at the initial consultation compared with the usual care group (47.7 versus 69.7 percent; adjusted odds ratio, 0.31); the results were similar during the first four weeks of follow-up (59.1 versus 79.7 percent; adjusted odds ratio, 0.30).

"The evidence from our trial suggests that CRP-guided antibiotic prescribing for COPD exacerbations in primary care clinics may reduce patient-reported use of antibiotics and the prescribing of antibiotics by clinicians," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.