Sleep Disturbances Linked to Cardiovascular Risks

Study of healthy subjects shows sleep disruption increases levels of inflammatory markers

FRIDAY, March 16 (HealthDay News) -- Even in healthy individuals, sleep disruptions are associated with a prothrombotic state that might contribute to coronary artery disease, according to study findings published in the March issue of Chest.

Roland von Kanel, M.D., of University Hospital Berne in Switzerland, and colleagues performed full-night polysomnography on 135 unmedicated men and women (mean age 36.8) who had no history of sleep disorders, and measured morning fasting plasma levels of von Willebrand Factor antigen, soluble tissue factor antigen, d-dimer and plasminogen activator inhibitor antigen.

The researchers found that poor general sleep efficiency predicted higher levels of soluble tissue factor antigen. They also found that perturbed sleep architecture and increased sleep fragmentation were associated with higher levels of von Willebrand Factor antigen and that sleep apnea severity was associated with higher levels of plasminogen activator inhibitor antigen.

"Different types of sleep disruption may therefore relate to different hemostatic factors, each representing a particular step in the hemostatic cascade," the authors write.

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