Aerosol Delivery May Be Useful Against Lung Cancer
Lentivirus-based carboxyl-terminal modulator protein linked to antitumor effect in mice
FRIDAY, June 12 (HealthDay News) -- Aerosol delivery of lentivirus-based carboxyl-terminal modulator protein (CTMP) in mice inhibited lung tumor growth at different stages of development, according to research published in the June 15 American Journal of Respiratory and Critical Care Medicine.
Soon-Kyung Hwang, of Seoul National University in Korea, and colleagues analyzed data from 9- and 13-week-old K-rasLA1 mice, which are a model of non-small cell lung cancer. Mice were exposed via the nose to aerosol containing a lentivirus-CTMP solution or lentivirus expression vector alone twice a week for four weeks; control mice were left untreated. CTMP serves as a negative regulator of Akt; Akt signaling has been associated with proliferation of a variety of tumor cells.
The researchers found that the treatment suppressed the progression of tumors from adenomas to adenocarcinomas. In the lungs of 9-week-old mice, the treatment inhibited protein synthesis and cell cycle, and altered the Akt signaling pathway. The lentivirus-CTMP also was associated with increased apoptosis in the lungs of 13-week-old mice.
"In conclusion, repeated aerosol gene delivery may provide an effective noninvasive model of gene delivery, and understanding the role of CTMP in the multistage lung tumorigenesis may be essential to developing effective therapeutics for lung cancer," the authors conclude.