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CT Perfusion May Predict Hemorrhagic Transformation

Pilot study suggests promising method for determining which stroke patients are at risk

MONDAY, Mar. 2 (HealthDay News) -- In patients with acute ischemic stroke, admission perfusion-derived permeability-surface area product (PS) measurement may differentiate those who are and are not likely to develop hemorrhagic transformation, according to the results of a pilot study published in the March issue of Radiology.

Richard I. Aviv, of the Sunnybrook Health Science Centre in Toronto, Ontario, Canada, and colleagues studied 41 patients who presented within three hours after stroke symptom onset and underwent two-phase computed tomography (CT) perfusion imaging, which enabled PS measurement.

The investigators found that 23 (56 percent) of patients progressed to hemorrhagic transformation. Compared to patients with no hemorrhage, they found that those who progressed to hemorrhage had a significantly increased PS in ischemic regions at admission. The researchers also report that the use of their acquisition protocol had a 77 percent sensitivity and a 94 percent specificity for predicting hemorrhagic transformation.

"It is important that we identified no significant difference in cerebral blood flow between the patients with and those without hemorrhage," the authors write.

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