3-D Imaging Better Detects Multiple Sclerosis Lesions

MP-RAGE imaging in particular is more effective than 2-D subtraction imaging

THURSDAY, April 1 (HealthDay News) -- Three-dimensional (3-D) subtraction magnetic resonance imaging produces better quality images and is more effective than two-dimensional (2-D) subtraction imaging in detecting active lesions in patients with multiple sclerosis (MS), according to a study in the April issue of Radiology.

Bastiaan Moraal, M.D., and colleagues from VU University Medical Center in Amsterdam, Netherlands, performed 3-D and 2-D subtraction magnetic resonance imaging twice in 14 patients with MS and nine age-matched healthy individuals.

The researchers found that the 3-D subtraction images were of better quality with less residual misregistration and flow artifacts, and that they depicted more active lesions with greater interobserver agreement compared with the 2-D images. T1-weighted magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) 3-D subtraction imaging detected a significantly higher mean number of positive active MS lesions than 2-D subtraction imaging (2.8 versus 1.7), particularly infratentorial lesions (0.6 versus 0.1).

"3-D subtraction imaging, after image registration, produced better image quality, leading to increased detection of active MS lesions with greater interobserver agreement in comparison with 2-D subtraction imaging; 3-D MP-RAGE subtraction imaging represents a promising technique to increase sensitivity in ascertaining lesion dissemination in time and increase the power of magnetic resonance imaging metrics for the evaluation of treatment effects in clinical trials," Moraal and colleagues conclude.

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