Nerve Injury in Rats Diagnosed Using MRI

Can determine degree of injury and prognosis

THURSDAY, May 1 (HealthDay News) -- T2-weighted MRI can be used to determine the degree and prognosis of peripheral nerve injury, according to the results of a study in rats published in the May issue of Radiology.

Eiko Yamabe, M.D., and colleagues from Keio University in Tokyo, Japan, examined the ability of T2-weighted MRI to assess peripheral nerve injury in rats with various types of injury to the left posterior tibial nerve.

The researchers found that the signal intensity was higher with more severe nerve damage. T2 ratios differed significantly between injured and non-injured rats, and changes in T2 ratios and values depended on the extent of nerve injury. T2 ratios and values began to decrease starting at 28 days after surgery for the reversible neurotmesis group and starting at 14 days after surgery for the severe and moderate axonotmesis groups.

"The degree and prognosis of nerve injury can be evaluated by observing changes in signal intensity on T2-weighted images and the time course of T2 values and ratios," Yamabe and colleagues conclude.

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