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CT Parameters Directly Reflect Tumor Angiogenesis

Quantitative perfusion computed tomography tied to microvessel density in colorectal cancer

MONDAY, Oct. 27 (HealthDay News) -- Quantitative perfusion computed tomography (CT) and immunohistologic markers are associated with angiogenesis in colorectal cancer, according to a report published online Sept. 23 Radiology.

Vicky Goh of Mount Vernon Hospital in Middlesex, England, and colleagues prospectively examined the relationship between quantitative perfusion CT parameters and immunohistologic markers of angiogenesis in colorectal cancer.

Overall, 23 patients (average age 68.4) with adenocarcinoma of the colon underwent quantitative perfusion CT to determine blood flow, blood volume, transit time and permeability surface-area product, which were found to be 72.1 milliliters per minute per 100 grams of tissue, 6.2 mL/100 g of tissue, 9.3 seconds, and 13.9 mL/min/100 g of tissue, respectively. Both blood volume and permeability surface-area product were significantly and positively correlated with microvessel density, but blood flow and transit time were not. No significant relationships were noted between quantitative perfusion CT parameters and pericyte coverage index, vascular endothelial growth factor score or glucose transporter protein score.

"In conclusion, our study results suggest that blood volume and permeability surface-area product measurements reflect angiogenesis and that perfusion CT is an appropriate technique for assessing tumor microvasculature," the authors write.

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