New Hayfever Vaccine Has Lasting Effect

6-shot, 6-week regimen works for more than one allergy season

WEDNESDAY, March 12, 2003 (HealthDayNews) -- Six injections of a new allergy vaccine over six weeks seems to fight hayfever for more than one allergy season, according to a Johns Hopkins study.

Johns Hopkins Medical Institutions researchers reported last year that this experimental vaccine for severe ragweed allergy dramatically reduced allergic symptoms such as sneezing, runny nose and nasal congestion. It also almost eliminated the need for decongestants and antihistamines.

In a new follow-up of people who continued in the study for a second year, the researchers have found that the initial six injections seem to be effective and safe for longer than a single allergy season.

The new vaccine is created by attaching immune-system-boosting molecules called oligonucleotides to Amb 1, the main ragweed protein that's responsible for causing allergic reactions.

The people in the follow-up phase of the study had improved hayfever symptoms and quality of life measurements, and less need for relief medications during the second ragweed season.

The changes in these areas were similar to what the people in the follow-up phase experienced during the first ragweed season after they received the vaccine injections.

The Johns Hopkins researchers presented their findings March 11 at the annual meeting of the American Academy of Allergy, Asthma and Immunology in Denver.

More information

Here's where you can learn more about hayfever and other allergies.

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