See What HealthDay Can Do For You
Contact Us

Antibiotic Use Tied to Higher Risk for Rheumatoid Arthritis

Findings show a dose- or frequency-dependent association; all antibiotic classes linked to higher odds for RA

arthritic hands

FRIDAY, Aug. 23, 2019 (HealthDay News) -- Antibiotic prescriptions are associated with a higher risk for rheumatoid arthritis (RA), according to a study published online Aug. 7 in BMC Medicine.

Alyshah Abdul Sultan, Ph.D., from Keele University in the United Kingdom, and colleagues used data from the primary care Clinical Practice Research Datalink to identify 22,677 patients with an incident diagnosis of RA (1995 to 2017). Cases were matched to 90,013 controls without RA based on age, gender, and general practice.

The researchers found that during a median follow-up of 10 years before RA diagnosis, the odds of developing RA were higher in those exposed to antibiotics (odds ratio [OR], 1.60) compared with those not exposed. There was a dose- or frequency-dependent association between the number of previous antibiotic prescriptions and RA. The odds of RA were higher for all classes of antibiotics, with bactericidal antibiotics carrying a higher risk than bacteriostatic (45 versus 31 percent). RA cases were most likely among those treated with antibiotics for upper respiratory tract infections. There were also increased odds of RA seen with antifungal (OR, 1.27) and antiviral (OR, 1.19) prescriptions.

"Antibiotic prescriptions are associated with a higher risk of RA," the authors write. "This may be due to microbiota disturbances or underlying infections driving risk."

Abstract/Full Text

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.