Meta-Analysis: ABCG2 Q141K Polymorphism Tied to Gout Risk
T allele linked to increased gout risk; association affected by gender, ethnicity
MONDAY, June 8, 2015 (HealthDay News) -- ABCG2 Q141K (rs2231142) is associated with gout risk, and gender and ethnicity affect the association, according to a meta-analysis published in the May issue of the International Journal of Rheumatic Diseases.
Zheng Dong, from Fudan University in Shanghai, and colleagues conducted a systematic review of studies to examine the association between rs2231142 and gout risk. Nine case-control studies involving 17,942 individuals were included in the meta-analysis.
The researchers found that the most appropriate genetic model to interpret the cause of susceptibility was the codominant model. This showed that the rs2231142 T allele increased gout risk, with the association for TT much stronger than GT (TT versus GG: odds ratio, 4.10; GT versus GG: odds ratio, 1.71). The association between rs2231142 and gout susceptibility was affected by gender and ethnicity.
"The above findings suggest a predictive role of ABCG2 rs2231142 polymorphism associated with gout susceptibility and this association is affected by gender and ethnicity diversity," the authors write.