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Trabecular Bone Texture Predicts Arthritis Progression

Medial joint space narrowing in knee arthritis most accurately predicted by tibial TB texture

FRIDAY, Oct. 21 (HealthDay News) -- Automated analysis of tibial trabecular bone (TB) texture in individuals with or without radiographic knee osteoarthritis shows promise for predicting progressive tibiofemoral joint space loss, according to a study published online Oct. 11 in Arthritis & Rheumatism.

Tomasz Woloszynski, from the University of Western Australia in Perth, and colleagues developed a system for predicting radiographic knee osteoarthritis (OA) progression using tibial TB texture. The analysis included 203 knees, with or without preexisting radiographic tibiofemoral OA, from 105 participants (90 men and 15 women; mean age, 54 years) who underwent two sets of knee radiographs four years apart. An automated region selection method was used to determine medial and lateral compartment tibial TB texture, and three texture parameters of roughness, degree of anisotropy, and direction of anisotropy were evaluated using the signature dissimilarity measure method. Tibiofemoral OA progression was assessed by the grade of the radiographic increase in the medial joint space narrowing (JSN). Logistic regression (generalized estimating equations) and receiver operating characteristic curves examined the predictive ability of the system, following adjustment for age, gender, and body mass index.

The investigators found that the medial TB texture was most accurate for predicting increased medial JSN with or without pre-existing radiographic OA, with an area under the curve (AUC) of 0.77 and 0.75, respectively. The corresponding AUCs for lateral TB texture were 0.71 and 0.72, respectively.

"We have developed a system, based on analyzing tibial TB texture, which yields good prediction of loss of tibiofemoral joint space," the authors write.

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