Black Women With Lupus Develop CVD at Younger Age

Comparisons of CVD hospitalizations and deaths find age disparities among racial/ethnic groups

WEDNESDAY, Aug. 25 (HealthDay News) -- Black women with systemic lupus erythematosus (SLE) are hospitalized for cardiovascular disease (CVD) events and die from them at younger ages than female SLE patients of other races and ethnic groups, according to a study published online May 6, ahead of the print issue of Arthritis & Rheumatism.

Lisabeth V. Scalzi, M.D., of the Pennsylvania State University College of Medicine in Hershey, and colleagues used the Nationwide Inpatient Sample database to identify 90,444 hospitalizations for adult subjects with SLE and approximately 19 million hospitalizations for subjects without SLE from 2003 to 2006. The data were analyzed for racial disparities in SLE patient age at the time of hospitalizations for CVD events and CVD-related death.

The researchers found that the SLE group was 89 percent women, compared to 61 percent in the non-SLE group. There were 3,627 hospitalizations for acute CVD among female SLE patients at a mean age of 60.8 compared to a mean age of 71.3 for female non-SLE subjects. Black women with SLE experienced CVD events at a mean age of 53.9 compared to 65.8 for black women without SLE and 63.5 for white women with SLE. Black women with SLE also were the youngest to die of CVD events compared to other racial groups (mean age 52.8 compared to 67.1 for whites, 62 for Hispanics, 63.8 for Asians). Among male SLE patients admitted for a CVD event, Hispanic and black groups were the youngest.

"Large multicenter and multi-ethnic studies are needed to examine if there are SLE specific indices that may be contributing to these age disparities," the authors write.

The research was supported in part by Pfizer.

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