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October 2007 Briefing - Rheumatology

Here are what the editors at HealthDay consider to be the most important developments in Rheumatology for October 2007. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Mortality Gap for Rheumatoid Arthritis Patients

MONDAY, Oct. 29 (HealthDay News) -- Mortality rates have remained high in patients with rheumatoid arthritis, despite declining mortality rates in the general population, according to the results of a study published in the November issue of Arthritis & Rheumatism.

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Synovio-Entheseal Complexes Linked to Synovitis

MONDAY, Oct. 29 (HealthDay News) -- Synovio-entheseal complexes are common at tendon or ligament attachment sites, are associated with degeneration and inflammation, and may be important in the pathogenesis of synovitis, researchers report in the November issue of Arthritis & Rheumatism.

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MicroRNAs Expressed in Muscle Conditions

FRIDAY, Oct. 26 (HealthDay News) -- MicroRNAs, which are small molecules that post-transcriptionally regulate gene expression, are differentially expressed in various degenerative muscle conditions, researchers report in the Oct. 23 issue of the Proceedings of the National Academy of Sciences.

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Gout Offers Some Protection Against Parkinson's Disease

TUESDAY, Oct. 23 (HealthDay News) -- Older men who have gout are less likely to develop Parkinson's disease, but this protection does not appear to extend to women, researchers report in the Oct. 23 issue of Neurology.

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Disparities Found Between Medicaid, Commercial Patients

WEDNESDAY, Oct. 10 (HealthDay News) -- Enrollees in Medicaid managed-care programs receive a poorer quality of health care than those in commercial managed-care programs, based on a variety of quality indicators, researchers report in the Oct. 10 issue of the Journal of the American Medical Association.

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Intensive Meditation Does Not Allay Arthritis Symptoms

FRIDAY, Oct. 5 (HealthDay News) -- Six months of Mindfulness-Based Stress Reduction does not ease rheumatoid arthritis symptoms, but seems to reduce patients' psychological distress levels, researchers report in the October issue of Arthritis Care & Research. The program was developed at the University of Massachusetts Medical School in Boston.

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Drug Reduces Aortic Stiffness in Marfan Syndrome

WEDNESDAY, Oct. 3 (HealthDay News) -- In patients with Marfan syndrome, a connective tissue disorder, perindopril reduces arterial stiffness and aortic root diameter, which often lead to aortic rupture and premature death, researchers report in the Oct. 3 issue of the Journal of the American Medical Association.

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Interaction Seen Between Acetaminophen and Caffeine

TUESDAY, Oct. 2 (HealthDay News) -- The cooperative binding of acetaminophen and caffeine in the P450 3A4 enzyme disrupts the coordination of acetaminophen to the heme iron, enhancing the rate of oxidation of acetaminophen to its toxic metabolite, N-acetyl-p-benzoquinone (NAPQI), according to a study published online Sept. 26 in Chemical Research in Toxicology.

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