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Allele Increases Proteinuria Risk in Lupus Patients

Higher risk also associated with younger age, anti-dsDNA antibodies

MONDAY, April 16 (HealthDay News) -- Patients with systemic lupus erythematosus have a higher risk of new or worsening proteinuria if they are younger, have anti-dsDNA antibodies, or have the HLA-DRB1*1503 allele, according to a study in the April issue of Rheumatology.

Graciela S. Alarcon, M.D., M.P.H., from the University of Alabama in Birmingham, and colleagues examined factors that could predict new or worsening urinary proteinuria in 529 patients with lupus. Patients were of varying ethnic origin: Texan Hispanic, Puerto Rican Hispanic, black, and white.

The researchers found that 243 patients developed new or worsening proteinuria, with Texan Hispanics and black patients most affected and whites least affected. Independent predictors of proteinuria were younger age (odds ratio, 1.013), anti-dsDNA antibodies (OR, 1.554), and the HLA-DRB1*1503 allele (OR, 1.746).

"The factors predictive of new or worsening proteinuria include traditional factors associated with lupus nephritis, such as age and anti-dsDNA, as well as HLA-DRB1*1503, which has not been previously described in association with lupus nephritis, new or worsening proteinuria," Alarcon and colleagues concluded.

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