IBD Increases Risk of Post-Op Thromboembolism

Risk of post-op deep vein thrombosis, pulmonary embolism higher after nonintestinal surgery

THURSDAY, Oct. 20 (HealthDay News) -- Patients with inflammatory bowel disease (IBD) have an increased risk of developing postoperative deep vein thrombosis (DVT) and pulmonary embolism (PE), with a higher risk in those undergoing nonintestinal surgery, according to a study published online Oct. 17 in the Archives of Surgery.

Andrea Merrill, M.D., from Massachusetts General Hospital in Boston, and Frederick Millham, M.D. from Newton Wellesley Hospital in Boston, investigated whether patients with IBD were at increased risk for postoperative DVT, PE, myocardial infarction, and stroke. The risks within 30 days of surgery were compared between 2,249 patients with IBD and 269,119 patients without IBD from 211 hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program.

The investigators identified 2,665 cases of DVT or PE (1.0 percent), with a higher occurrence in patients with IBD (2.5 percent ). The rate of DVT or PE was higher for nonintestinal surgical cases (5.0 percent). After adjusting for confounders in regression analysis, the correlation of IBD with increased risk of DVT or PE was confirmed (odds ratio [OR], 2.03). The risk of DVT or PE for patients with IBD was increased for nonintestinal surgery (OR, 4.45). IBD did not correlate with the risk of postoperative myocardial infarction or stroke risk.

"Patients with IBD who undergo surgery have a two-fold increased risk of DVT or PE. In patients with IBD who are having nonintestinal surgery, this risk may be even higher," the authors write.

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