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Statins Improve Outcomes After Vascular Surgery

Lower LDL cholesterol also associated with improved outcomes

TUESDAY, Oct. 16 (HealthDay News) -- Higher statin dose and lower low-density lipoprotein (LDL) cholesterol are associated with decreased rates of myocardial ischemia, troponin T release, and early and late cardiac events after vascular surgery, according to a study published online Oct. 6 in the Journal of the American College of Cardiology.

Harm H.H. Feringa, M.D., from Erasmus Medical Center in Rotterdam, the Netherlands, and colleagues examined the role of higher statin dose and lower LDL cholesterol on cardiac outcome in 359 vascular surgery patients.

The researchers found that both higher statin dose and lower LDL cholesterol were associated with less myocardial ischemia (odds ratio 0.85 and 0.87, respectively), troponin T release (odds ratio 0.84 and 0.89, respectively), 30-day cardiac events (odds ratio 0.62 and 0.89, respectively), and late cardiac events (odds ratio 0.76 and 0.91, respectively).

"Higher statin doses and lower LDL cholesterol correlate with lower perioperative myocardial ischemia, perioperative troponin T release, and 30-day and late cardiac events in major vascular surgery," Feringa and colleagues concluded.

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