Fibrin Glue Enhances Survival of Autologous Fat Grafts

Mouse study finds autologous fat grafts show less resorption when implanted with fibrin glue

FRIDAY, March 9 (HealthDay News) -- Fibrin glue can enhance the survival of autologous fat grafts, according to the results of an animal study published in the March issue of the Journal of Plastic, Reconstructive & Aesthetic Surgery.

Naci Karacal, M.D., of Karadeniz Technical University in Trabzon, Turkey, and colleagues tested the effect of fibrin glue on fat graft survival in 10 Sprague-Dawley rats. Autogenous fat grafts were implanted bilaterally in conjunction with either fibrin glue or saline, and then harvested at six months.

The animals tolerated the grafting procedure, and the implants exhibited neither necrosis nor liquefaction. Fat grafts containing fibrin glue showed significantly better survival than did those implanted with saline (79 percent of initial volume versus 55 percent). Histopathological data demonstrated that the fibrin glue-aided implants were newly vascularized.

"Fibrin sealants may enhance the overall outcome of surgical intervention because of their adhesive and vasoactive properties, but double-blinded, controlled clinical trails are required to quantify their effects and to provide conclusive evidence of their contribution to oral and maxillofacial surgery," the authors conclude.

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