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Glucose Marker Helps Measure Prostate Surgery Fluid Uptake

Study finds method can determine fluid absorption in bipolar transurethral resection

WEDNESDAY, Dec. 16 (HealthDay News) -- Adding glucose to an electrolyte-containing irrigation fluid helps detect absorption in bipolar transurethral resection of the prostate, according to a study in the December issue of Anesthesia & Analgesia.

David Piros, M.D., of the Karolinska Institutet at Söder Hospital in Stockholm, Sweden, and colleagues conducted a study of 250 patients undergoing monopolar transurethral resection of the prostate with either 1.5 percent glycine or 5 percent glucose urinary bladder irrigation. Using data from observation of glucose kinetics in 10 volunteers given a glucose solution, the researchers were able to produce a computer simulation of absorption patterns relative to the volume of fluid administered.

Among the patients administered 5 percent glucose during transurethral resection of the prostate, there was a linear inverse relationship between the decrease in serum sodium and the increase in glucose levels, the researchers found. The simulations showed a 1 L uptake of fluid containing 1 percent glucose resulted in an increase in the glucose level of 3.7 mmol/L, and a 2 L uptake produced a 6.9 mmol/L increase in glucose at the end of surgery.

"The use of an electrolyte-containing solution with 1 percent glucose for bladder irrigation during bipolar transurethral resection of the prostate is likely to detect clinically significant fluid absorption greater than 1 L by measuring plasma glucose at least during the first 30 min of the postoperative period," the authors write.

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