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Tolterodine Can Relieve Overactive Bladder Micturitions

Extended-release drug causes reduction in nighttime and daytime micturitions due to overactive bladder

THURSDAY, April 20 (HealthDay News) -- Tolterodine extended release (TER) taken four hours or less before bed helps reduce nighttime micturitions due to overactive bladder, according to a study in the April issue of Urology.

Raymond Rackley, M.D., of the Cleveland Clinic in Ohio and colleagues put 850 overactive bladder patients with eight or more micturitions a day and at least 2.5 episodes per night on 4 milligrams of TER or placebo before bed for 12 weeks.

TER caused a drop in nocturnal and daytime micturitions due to overactive bladder and severe overactive bladder. TER modestly cut the overall number of nighttime micturitions, but there was no statistically significant reduction compared with placebo.

"TER significantly reduced overactive bladder-related micturitions during 24-hour, daytime and nighttime intervals," the authors write. "TER did not affect normal (non-overactive bladder) micturitions. Nighttime dosing with TER was associated with few adverse events and adverse event-related withdrawals."

In an editorial, Gary E. Lemack, M.D., of the University of Texas Southwestern Medical Center in Dallas, congratulates the authors "on an interesting and provocative study that sought to answer some of the questions that still trouble us in our care for patients with overactive bladder."

Rackley is a paid consultant to Novartis, Pfizer and Yamanouchi.

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