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Exercise Linked to Less Risk of High-Grade Prostate Cancer

And, African-American men with higher LDL cholesterol show higher risk of prostate cancer

FRIDAY, Nov. 13 (HealthDay News) -- Exercise was associated with lower risk of prostate cancer upon biopsy, as well as lower risk of high-grade disease in those with cancer, and African-American men with increased low-density lipoprotein (LDL) showed a higher likelihood of prostate cancer diagnosis, according to two studies in the November issue of The Journal of Urology.

Jodi A. Antonelli, M.D., of the Duke University Medical Center in Durham, N.C., and colleagues analyzed data from men who underwent prostate biopsy, and reported on their exercise patterns. After adjustment for a variety of factors, men reporting at least nine metabolic equivalent task (MET) hours of exercise each week had a lower risk of cancer upon biopsy. Among men who did have cancer, those with three to 8.9 MET hours per week were less likely to have high-grade disease at biopsy.

Kelvin A. Moses, M.D., of the Atlanta Veterans Affairs Medical Center, and colleagues analyzed data from 1,775 men who underwent prostate biopsy. Of this group, 972 had positive biopsies. Compared to those with LDL of 100 mg/dL or less, the odds ratio for prostate cancer in African-American men was 1.49 in those with LDL of more than 100 to 130 mg/dL, 1.51 in those with LDL of more than 130 to 160 mg/dL, and 3.24 in those with LDL of more than 160mg/dL, an association was not seen in other races.

"Our results lend further support to the hypothesis that exercise may decrease the risk of prostate cancer and for men with cancer it may decrease the risk of high-grade disease. These results are consistent with biochemical evidence which has shown exercise affects molecular pathways central to prostate cancer tumor biology," Antonelli and colleagues conclude.

A co-author of the second study reported a relationship with the American Urological Association.

Abstract - Antonelli
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Abstract - Moses
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