Bread Intake Linked to Risk of Renal Cell Carcinoma

Vegetable consumption may lower risk of the neoplasm

MONDAY, Oct. 23 (HealthDay News) -- A diet with a high bread intake is associated with an increased risk of renal cell carcinoma, while consuming high amounts of both raw and cooked vegetables is associated with a lower risk, according to the results of a large case-control study published online Oct. 20 in the International Journal of Cancer.

Francesca Bravi, Ph.D., of the Istituto di Ricerche Farmacologiche Mario Negri in Milan, Italy, and colleagues found that study participants in the highest quintile of bread consumption had a 94 percent increased risk of developing renal cell carcinoma, when compared to participants in the lowest quintile. Researchers speculate that these foods increase cancer risk due to their high glycemic load and possible effect on insulin-like growth factor. Rice and pasta consumption were also associated with a small, but non-significant, increased risk for the cancer.

By contrast, increased consumption of both raw and cooked vegetables decreased the risk of renal cell carcinoma most likely because of their antioxidant and anticarcinogenic properties. Consuming poultry and processed meat also decreased risk of the neoplasm, the report indicates.

"Our results confirm that diet may play a role on the risk of renal cell carcinoma, and in particular, a moderate cereal and high vegetables consumption may have a favorable effect on this neoplasm," the study authors conclude.

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